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Published online before print May 17, 2006, doi:10.1212/01.wnl.0000228862.76269.62)
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Received January 4, 2006
Accepted April 4, 2006

Episodic neurologic dysfunction with migraine and reversible imaging findings after radiation

A. Pruitt MD, J. Dalmau MD, PhD, J. Detre MD, A. Alavi MD, and M. R. Rosenfeld MD, PhD*

From the Division of Neuro-oncology (A.P., J.D., J.D., M.R.R.), Department of Neurology, and Division of Nuclear Medicine (A.A.), Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia.


* To whom correspondence should be addressed. E-mail: myrna.rosenfeld{at}uphs.upenn.edu.

Abstract-- Reported are three adults who developed frequent episodes of a complex neurologic syndrome years after radiation therapy for a brain tumor. MRI and [18F]fluorodeoxyglucose PET performed during the episodes demonstrated dramatic gyral thickening with enhancement and intense hypermetabolism in symptomatic regions that resolved on follow-up studies. EEG during episodes showed only slowing. The differential diagnosis and imaging findings are reviewed.




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