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Published online before print June 14, 2006, doi:10.1212/01.wnl.0000231138.18629.d5)
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Received October 3, 2005
Accepted March 27, 2006

Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen

S. Evers MD, PhD*, A. Rahmann MD, C. Kraemer MD, G. Kurlemann MD, O. Debus MD, I. W. Husstedt MD, and A. Frese MD

From the Departments of Neurology (S.E., A.R., C.K., I.W.H., A.F.) and Neuropaediatrics (G.K., O.D.), University of Münster, Germany.


* To whom correspondence should be addressed. E-mail: everss{at}uni-muenster.de.

Abstract-- The authors conducted a double-blind, placebo-controlled, crossover study to investigate the efficacy of oral zolmitriptan in the treatment of migraine in children and adolescents. Patients (n = 32) received placebo, zolmitriptan 2.5 mg, and ibuprofen 200 to 400 mg to treat three consecutive migraine attacks. Pain relief rates after 2 hours were 28% for placebo, 62% for zolmitriptan, and 69% for ibuprofen (p < 0.05). Both drugs are well tolerated with only mild side effects.




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Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen
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Neurology Online, 31 Oct 2006 [Full text]

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