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Published online before print August 16, 2006, doi:10.1212/01.wnl.0000233831.87781.a9)
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Received February 20, 2006
Accepted June 7, 2006

Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients

J. M. Leung MD, MPH*, L. P. Sands PhD, M. Rico BS, K. L. Petersen MD, M. C. Rowbotham MD, J. B. Dahl MD, C. Ames MD, D. Chou MD, and P. Weinstein MD

From the Departments of Anesthesia & Perioperative Care (J.M.L., M.R.), Neurology (K.L.P., M.C.R.), and Neurological Surgery (C.A., D.C., P.W.), University of California, San Francisco; Purdue University (L.P.S.), School of Nursing, West Lafayette, IN; and Glostrup University Hospital (J.B.D.), Glostrup, Denmark.


* To whom correspondence should be addressed. E-mail: leungj{at}anesthesia.ucsf.edu.

Abstract-- In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.




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