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Published online before print November 5, 2008, doi:10.1212/01.wnl.0000327823.81237.d1)
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Received February 26, 2008
Accepted July 2, 2008

Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset

W. C. Nichols PhD*, N. Pankratz PhD, D. K. Marek BS, M. W. Pauciulo MBA, V. E. Elsaesser BS, C. A. Halter MS, A. Rudolph PhD, J. Wojcieszek MD, R. F. Pfeiffer MD, T. Foroud PhD, For the Parkinson Study Group–PROGENI Investigators

From Cincinnati Children's Hospital Medical Center (W.C.N., D.K.M., M.W.P., V.E.E.), OH; University of Cincinnati School of Medicine (W.C.N.), OH; Indiana University Medical Center (N.P., C.A.H., J.W., T.F.), Indianapolis; University of Rochester (A.R.), NY; and University of Tennessee Health Science Center (R.F.P.), Memphis.


* To whom correspondence should be addressed. E-mail: bill.nichols{at}cchmc.org.

Objective: To characterize sequence variation within the glucocerebrosidase (GBA) gene in a select subset of our sample of patients with familial Parkinson disease (PD) and then to test in our full sample whether these sequence variants increased the risk for PD and were associated with an earlier onset of disease.

Methods: We performed a comprehensive study of all GBA exons in one patient with PD from each of 96 PD families, selected based on the family-specific lod scores at the GBA locus. Identified GBA variants were subsequently screened in all 1325 PD cases from 566 multiplex PD families and in 359 controls.

Results: Nine different GBA variants, five previously reported, were identified in 21 of the 96 PD cases sequenced. Screening for these variants in the full sample identified 161 variant carriers (12.2%) in 99 different PD families. An unbiased estimate of the frequency of the five previously reported GBA variants in the familial PD sample was 12.6% and in the control sample was 5.3% (odds ratio 2.6; 95% confidence interval 1.5–4.4). Presence of a GBA variant was associated with an earlier age at onset (p = 0.0001). On average, those patients carrying a GBA variant had onset with PD 6.04 years earlier than those without a GBA variant.

Conclusions: This study suggests that GBA is a susceptibility gene for familial Parkinson disease (PD) and patients with GBA variants have an earlier age at onset than patients with PD without GBA variants.




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Correspondence:

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Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset
Ellen Sidransky, et al.
Neurology Online, 23 Feb 2009 [Full text]
Reply from the authors
William C. Nichols, et al.
Neurology Online, 23 Feb 2009 [Full text]

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