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NEUROLOGY 2006;67:170-173
© 2006 American Academy of Neurology
Brief Communications

Are elevated admission calcium levels associated with better outcomes after ischemic stroke?

B. Ovbiagele, MD, D. S. Liebeskind, MD, S. Starkman, MD, N. Sanossian, MD, D. Kim, MD, T. Razinia, BS and J. L. Saver, MD

From the Stroke Center and Department of Neurology (B.O., D.S.L., S.S., N.S., D.K., T.R., J.L.S.) and Department of Emergency Medicine (S.S.), UCLA Medical Center, Los Angeles, CA.

Address correspondence and reprint requests to Dr. Bruce Ovbiagele, Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095; e-mail: ovibes{at}mednet.ucla.edu

Calcium (Ca2+) and magnesium (Mg2+) influence the molecular pathways of ischemic neuronal death. The authors evaluated the impact of admission serum Ca2+ and Mg2+ levels, on incident stroke severity and discharge functional outcome. After adjusting for covariates, higher admission Ca2+ was significantly associated with lesser stroke severity and better discharge functional outcome. Admission Mg2+ was not an independent clinical outcome prognosticator.

This study was supported in part by NIH-National Institute of Neurologic Disorders and Stroke Awards P50 NS044378.

Disclosure: The authors report no conflicts of interest.

Received November 17, 2005. Accepted in final form March 17, 2006.




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B. H. Buck, D. S. Liebeskind, J. L. Saver, O. Y. Bang, S. Starkman, L. K. Ali, D. Kim, J. P. Villablanca, N. Salamon, S. W. Yun, et al.
Association of Higher Serum Calcium Levels With Smaller Infarct Volumes in Acute Ischemic Stroke
Arch Neurol, September 1, 2007; 64(9): 1287 - 1291.
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