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An adult case of leukoencephalopathy with intracranial calcifications and cysts

From the Departments of Neurology (J.R.C., B.K.K.-D.), Pathology (B.K.K.-D.), and Neurosurgery (J.G., B.K.K.-D.), University of Colorado Health Sciences Center, Denver, CO; and Department of Neurology (J.R.C.), Denver Veterans Affairs Medical Center, Denver, CO.

Address correspondence and reprint requests to Dr. John R. Corboy, Department of Neurology, Box B-183, University of Colorado at Denver and Health Sciences Center, 4200 E. Ninth Avenue, Denver, CO 80262; e-mail: john.corboy{at}uchsc.edu

We describe a 44-year-old woman with progressive headache, ataxia, and seizures in association with multifocal cerebral and cerebellar leukoencephalopathy, intracranial calcifications, and cysts. The cause of death was intracerebellar hemorrhage while taking warfarin. Pathologic features on biopsy included angiomatous-like blood vessels, intense gliosis, and Rosenthal fiber formation in the white matter. Genetic analyses did not identify any significant mutations in two candidate genes.

Disclosure: The authors report no conflicts of interest.

This case was presented in abstract form at the XVI International Congress of Neuropathology, San Francisco, CA, September 9–15, 2006.

Received May 1, 2006. Accepted in final form August 3, 2006.

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