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NEUROLOGY 2006;67:1674-1676
© 2006 American Academy of Neurology
Brief Communications

Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy

S. Takaya, MD, T. Hanakawa, MD, PhD, K. Hashikawa, MD, PhD, A. Ikeda, MD, PhD, N. Sawamoto, MD, PhD, T. Nagamine, MD, PhD, K. Ishizu, MD, PhD and H. Fukuyama, MD, PhD

From the Human Brain Research Center (S.T., T.H., K.H., N.S., T.N., H.F.), Department of Neurology (A.I.), and Department of Nuclear Medicine and Diagnostic Radiology (K.I.), Kyoto University Graduate School of Medicine, Kyoto, Japan.

Address correspondence and reprint requests to Dr. H. Fukuyama, Human Brain Research Center, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; e-mail: fukuyama{at}bpp2.kuhp.kyoto-u.ac.jp

We compared the cognitive functions and interictal cerebral glucose metabolism of 11 patients with mesial temporal lobe epilepsy (MTLE) with frequent seizures to those of 10 patients with MTLE with rare seizures; the groups were matched for age, sex, education, IQ, and focus side. The frequent-seizure group had more set-shifting impairment that correlated with glucose hypometabolism in the prefrontal cortices. Our results suggest that frequent seizures in MTLE are associated with hypofunction of the prefrontal cortex.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 14 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received March 27, 2006. Accepted in final form July 17, 2006.






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