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NEUROLOGY 2006;67:1687-1689
© 2006 American Academy of Neurology
Brief Communications

A randomized, placebo-controlled study of donepezil in poststroke aphasia

M. L. Berthier, MD, PhD, C. Green, PhD, C. Higueras, PhD, I. Fernández, PhD, J. Hinojosa, PhD and M. C. Martín, PhD

From Centro de Investigaciones Médico-Sanitarias (CIMES) (M.L.B., C.G., C.H., J.H.), University of Malaga School of Medicine; and Language Rehabilitation Center (CIMPER) (I.F., M.C.M.), Malaga, Spain.

Address correspondence and reprint requests to Dr Berthier, Centro de Investigaciones Médico-Sanitarias (CIMES), Universidad de Málaga, Campus Teatinos, 29071 Málaga, Spain; e-mail: mberthier{at}terra.es, mbt{at}uma.es

We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).

Disclosure: Dr. M.L. Berthier has received honoraria from Pfizer Spain, Eisai, Janssen-Cilag, Novartis, Lundbeck, and Merz in excess of $10,000. Dr. C. Green has received honoraria from Janssen-Cilag and Lundbeck. Pfizer Spain and Eisai supplied the active medication and placebo.

Received March 27, 2006.

Accepted in final form July 7, 2006.






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