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ARTICLES: R. A. Hauser, S. Furtado, C. R. Cimino, H. Delgado, S. Eichler, S. Schwartz, D. Scott, G. M. Nauert, E. Soety, V. Sossi, D. A. Holt, P. R. Sanberg, A. J. Stoessl, and T. B. Freeman Bilateral human fetal striatal transplantation in Huntington’s disease Neurology 2002; 58: 687-695 [Abstract] [Full text] [PDF]

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Editor's note

Robert C. Griggs   (4 April 2002)

Reply to Letter to the Editor

J. Timothy Greenamyre, Ira Shoulson University of Rochester Rochester NY   (4 April 2002)

Bilateral human fetal striatal transplantation in Huntington’s disease

Robert A Hauser, Paul R. Sanberg, A Jon. Stoessl, and Thomas B. Freeman   (4 April 2002)

Editor's note 4 April 2002
Robert C. Griggs Neurology Journal Editorial Office Rochester NY Send Correspondence to journal: Re: Editor's note neuro_journal{at}urmc.rochester.edu Robert C. Griggs	Inadvertently, the Neurology office did not send the final accepted version of the Hauser et al. paper to Drs. Greenamyre and Shoulson. Thus their editorial criticized statements that were no longer part of the published paper. We apologize to Dr. Hauser et al. and Drs. Greenamyre and Shoulson for the error.
Reply to Letter to the Editor 4 April 2002
J. Timothy Greenamyre Emory University Atlanta GA, Ira Shoulson University of Rochester Rochester NY Send Correspondence to journal: Re: Reply to Letter to the Editor jgreena{at}emory.edu J. Timothy Greenamyre, et al.	It is unfortunate that we did not have the opportunity to see the final accepted version of the report by Hauser et al. who apparently took the reviewers' comments to heart and toned down their original conclusion, which we called "a stretch". We agree with Hauser et al. that the final published version presents a more balanced description of their results.
Bilateral human fetal striatal transplantation in Huntington’s disease 4 April 2002
Robert A Hauser Tampa General Healthcare Tampa FL, Paul R. Sanberg, A Jon. Stoessl, and Thomas B. Freeman Send Correspondence to journal: Re: Bilateral human fetal striatal transplantation in Huntington’s disease rhauser{at}hsc.usf.edu Robert A Hauser, et al.	Referring to our report, "Bilateral human fetal striatal transplantation in Huntington's disease," [1] Greenamyre and Shoulson [2] suggest that we concluded that "a lack of significant worsening might reflect clinical benefit in a progressive neurodegenerative disease" and state that "this conclusion is a stretch." However, regarding our study, we indicated that "we did not definitively demonstrate a lack of significant worsening owing to the small number of subjects and the open label design of the study. We also cannot exclude the influence of random chance, bias, or placebo effects." Our study was intended to evaluate feasibility and safety, and was not designed to definitively assess efficacy. We concluded that transplantation of human fetal striatal cells is feasible and survival of transplanted cells was demonstrated, but patients with moderately advanced Huntington's disease are at risk for subdural hemorrhage after transplantation surgery. We believe that our published manuscript provides a fair and balanced description of our observations and agree with the editorialists that we need better treatments for this devastating disease. References: 1) Hauser RA, Furtado S, Cimino CR, et al. Bilateral human fetal striatal transplantation in Huntington's disease. Neurology 2002;58:687- 695. 2) Greenamyre JT, Shoulson I. We need something better, and we need it now: Fetal striatal transplantation in Huntington's disease? Neurology 2002;58:675-676.