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BRIEF COMMUNICATIONS: Anna Pichiecchio, Carla Uggetti, Maria Grazia Egitto, and Federico Zappoli Parry–Romberg syndrome with migraine and intracranial aneurysm Neurology 2002; 59: 606-608 [Abstract] [Full text] [PDF]

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Reply to Olivares-Romero

Anna Pichiecchio, C.Uggetti, M.G.Egitto, F.Zappoli   (3 October 2002)

Parry–Romberg syndrome with migraine and intracranial aneurysm

Jesús Olivares-Romero, PJ Serrano-Castro, JI Peralta-Labrador, P Guardado-Santervás, A. Arjona-Padillo and E. Goberna-Ortiz   (3 October 2002)

Reply to Olivares-Romero 3 October 2002
Anna Pichiecchio Servizio di Neuroradiologia, Mondino Italy, C.Uggetti, M.G.Egitto, F.Zappoli Send Correspondence to journal: Re: Reply to Olivares-Romero anna.pichiecchio{at}mondino.it Anna Pichiecchio, et al.	We thank Dr. Olivares-Romero for his interest in our article. We note he previously described a further case of Parry – Romberg syndrome whose clinical and MR findings could further support the malformative hypothesis, initially proposed by Dupont and Schievink [2, 5] and further supported by our patients’ findings. The possibility that the disease could be related to a damage of the neural plate during its early development now seems likely; further careful clinical examinations and genetic researches need to be done to add more to our understanding of the complex pathogenetic mechanisms underlying Progressive Facial Hemiatrophy. 5. Schievink WI, Mellinger JF, Atkinson JLD. Progressive intracranial aneurysmal disease in a child with progressive hemifacial atrophy (Parry- Romberg disease): case report. Neurosurgery 1996;38:1237-1240.
Parry–Romberg syndrome with migraine and intracranial aneurysm 3 October 2002
Jesús Olivares-Romero, Neurologist. Neurology Service. Hospital Torrecárdenas. ALMERÍA. SPAIN., PJ Serrano-Castro, JI Peralta-Labrador, P Guardado-Santervás, A. Arjona-Padillo and E. Goberna-Ortiz Send Correspondence to journal: Re: Parry–Romberg syndrome with migraine and intracranial aneurysm pserrano{at}meditex.es Jesús Olivares-Romero, et al.	We read with interest the article of Pichiecchio et al [1] of a new case of Progressive Facial Hemiatrophy (PFH) associated with migraine and intracranial aneurysm. The authors suggest a malformative hypothesis with involvement, at the same time, of vascular and mesenchymal structures with common progenitors in the neural crest. This hypothesis had been previously suggested [2-4]. We recently published a case of PFH followed up for 13 years [4]. During this time, the patient associated clinical signs of progressive cortical (with partial clonic seizures in the right leg with jacksonian progression and secondary generalization) and cerebellar dysfunction (dysartrhia and ataxia). The MRI showed a pattern of progressive atrophy of left temporal, pontine, mesencephalic and cerebellar structures. These structures are embryologically related to ipsilateral rostral neural tube. This supports the hypothesis that damage occured during the early development of the neural plate. REFERENCES 1) Pichiecchio A, Uggetti C, Egitto MG, Zappoli F. Parry-Romberg syndrome with migraine and intracranial aneurysm. Neurology 2002; 59: 606- 608. 2) Dupont S, Catala M, Hasboun D, et al. Progressive facial hemiatrophy and epilepsy: a common underlying dysgenetic mechanism. Neurology 1997; 48: 1013-18 3) Derex L, Isnard H, Revol M. Progressive facial hemiatrophy with multiple benign tumors and hamartomas. Neuropediatrics 1995; 26: 306-9. 4) Olivares -Romero J, Casado -Torres A, Serrano- Castro PJ, et al. Hemiatrofia facial progresiva de Parry-Romberg: consideraciones patogénicas y evolutivas a propósito de un caso con seguimiento prolongado. Rev Neurol 1999; 29: 1032-1035.