Neurology -- Correspondence for Mosquera et al., 60 (10) 1577-1580

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ARTICLES:
Aurelio Mosquera, Luis A. Idrovo, Alfonso Tafur, and Oscar H. Del Brutto
Stroke following Bothrops spp. snakebite
Neurology 2003; 60: 1577-1580 [Abstract] [Full text] [PDF]

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Stroke following Bothrops spp. snakebite: Jacob C. Tony, 4 Eltham Gardens, Maybank, Newcastle-under-Lyme, staffs, UK, ST5 OJR (25 June 2003)

Stroke following Bothrops spp. snakebite 25 June 2003

Jacob C. Tony,
Physician
Specialist Registrar, Medicine,,
4 Eltham Gardens, Maybank, Newcastle-under-Lyme, staffs, UK, ST5 OJR
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Re: Stroke following Bothrops spp. snakebite

tjacob33{at}hotmail.com Jacob C. Tony, et al.

In explaining the pathogenesis of cerebral infarction following snake bite, Mosquera et al suggest a procoagulant effect of the venom and toxic angiitis of intracranial vessels as the cause for cerebral infarction [1]. Sarafotoxin in snake venom has vascular toxic effects leading to vasospasm particularly in the coronary vessels [2]. Myocardial infarction following snake bite has been reported, and sarafotoxins are implicated in such situations [3]. Sarafotoxin-like peptides in the venom of Bothrops spp. may contribute to cerebral infarction in a similar manner as the pathogenesis of myocardial infarction.
References
1. Mosquera A, Idrovo LA, Tafur- A, Dell Brutto OH.Stroke following Bothrops spp.snakebite.Neurology2003;60:1577-1580.
2. Wollberg Z,Bdolah A,Kochva E. Cardiovascular effects of mammalian endothelins and snake venom sarafotoxins.In:Abraham S, Amitai G,eds.Calcium Channel Modulators in Heart and smooth Muscle. Florida:VCH, Weinheim/Deerfield Beach,1990:283-99
3. Tony JC, Bhat R. Acute myocardial infarction following snake bite.Tropical Doctor. 1995;25:137