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CLINICAL IMPLICATIONS OF NEUROSCIENCE RESEARCH: Eduardo E. Benarroch Subthalamic nucleus and its connections: Anatomic substrate for the network effects of deep brain stimulation Neurology 2008; 70: 1991-1995 [Abstract] [Full text] [PDF]

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Subthalamic nucleus and its connections: Anatomic substrate for the network effects of deep brain

Victor W. Mark   (14 July 2008)

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Eduardo E. Benarroch   (14 July 2008)

Subthalamic nucleus and its connections: Anatomic substrate for the network effects of deep brain 14 July 2008
Victor W. Mark, University of Alabama at Birmingham 619 19th Street South, SRC 190, Birmingham AL 35249-7330 Send Correspondence to journal: Re: Subthalamic nucleus and its connections: Anatomic substrate for the network effects of deep brain vwmark{at}uab.edu Victor W. Mark	Benarroch's review on the anatomical connections of the subthalamic nucleus (STN) and their clinical correspondences does not mention the interhemispheric relays between the STN with the contralateral STN or other basal ganglia. [1] We reported bilateral ballism following unilateral STN infarction and interpreted our findings with respect to the bilateral interconnections of the STN. [2] We noted the tendency among contemporary reviews to omit discussing interhemispheric relays of the STN. Our study provided several references for these interhemispheric connections and their basic neuroscience and clinical relevance, including deep-brain stimulation. I believe a clinico-anatomical discussion of the STN is incomplete without referring to its interhemispheric connections. References 1. Benarroch EE. Subthalamic nucleus and its connections: Anatomic substrate for the network effects of deep brain stimulation [review]. Neurology 2008;70:1991-1995. 2. Mark VW, Oberheu AM, Henderson C, Woods AJ. Ballism following stroke responds to simple therapeutic interventions. Arch Phys Med Rehabil 2005;86:1226-1233. Disclosures: The author has no disclosures
Reply from the author 14 July 2008
Eduardo E. Benarroch, Mayo Clinic, Rochester, MN 200 First Street SW Rochester, MN 55905 Send Correspondence to journal: Re: Reply from the author benarroch.eduardo{at}mayo.edu Eduardo E. Benarroch	I appreciate Dr. Mark's comments on my short review where I focused on subthalamic nucleus connections that have been best characterized in experimental animals using modern neuroanatomical techniques. However, this does not exclude the presence and potential functional significance of commissural subthalamic nucleus connections, as reported by Mark et al. [2] I appreciate Dr Mark's emphasizing the potential significance of these connections for the effects of deep brain stimulation and rehabilitation techniques. Disclosures: The author has no disclosures