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Cardiovascular health in young adulthood and structural brain MRI in midlife

The CARDIA study

  1. Pamela J. Schreiner, PhD
  1. From Northwestern University (M.P.B., N.B.A., D.M.L.-J.), Chicago, IL; Mount Sinai Medical Center Radiology (P.D.), Miami Beach, FL; National Institute on Aging (L.J.L.); National Heart, Lung, and Blood Institute (J.P.R.), Bethesda, MD; Kaiser Permanente Northern California (S.S.), Oakland; University of Mississippi Medical Center (Y.Y.), Jackson; and University of Minnesota (P.J.S.), Minneapolis.
  1. Correspondence to Dr. Bancks: michael.bancks{at}northwestern.edu
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  1. NONE

Research Support, Government Entities:

  1. (1) National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Numbers; T32HL007779; pre-doctoral trainee; 1 year (2) National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Numbers; T32HL069771; postdoctoral trainee; 1 year

Research Support, Academic Entities:

  1. (1) University of Minnesota, School of Public Health, Division of Epidemiology & Community Health, Minneapolis, MN

Research Support, Foundations and Societies:

  1. NONE

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Research Support, Commercial Entities:

  1. Co-investigator on a grant funded by Novartis

Research Support, Government Entities:

  1. grant support from the NIH/NHLBI

Research Support, Academic Entities:

  1. NONE

Research Support, Foundations and Societies:

  1. grant support from the American Heart Association

Stock/Stock Options/Board of Directors Compensation:

  1. NONE

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Research Support, Commercial Entities:

  1. NONE

Research Support, Government Entities:

  1. National Institute on Aging Intramural Research Program, Employee, 1999-present

Research Support, Academic Entities:

  1. NONE

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  1. NONE

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  1. NONE

Editorial Boards:

  1. 1. Current Cardiovascular Risk Reports, Hypertension Section Editor, 2006-2011 2. Circulation: Cardiovascular Quality and Outcomes, Editorial Board, 2008-2013 3. Global Heart, Editorial Advisory Board, 2011-2016 4. JAMA Cardiology, Senior Editorial Advisory Board, 2016- present

Patents:

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Employment, Commercial Entity:

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Clinical Procedures or Imaging Studies:

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Research Support, Commercial Entities:

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Research Support, Government Entities:

  1. This is ridiculous. Numerous NIH grants.

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Employment, Commercial Entity:

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Scientific Advisory Boards:

  1. All Non-Profit Entities: (1) National Forum for Heart Disease and Stroke Prevention (2) GRADE DSMB (3) Alameda-Contra Costa Medical Association

Gifts:

  1. NONE

Funding for travel or speaker honoraria:

  1. All Non-Profit Entities: (1) National Forum for Heart Disease and Stroke Prevention (2) GRADE DSMB

Editorial Boards:

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Employment, Commercial Entity:

  1. The Permanente Medical Group, Senior Research Scientist and Director of Research Clinics. 34 years in research scientist position

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Research Support, Government Entities:

  1. Funded as principal investigator on NHLBI Contract N01 HC-48050 12/30/83-6/30/18; Funded as principal investigator on NINDS U54NS081760 10/1/12-9/30/17; Funded as co-investigator on NINDS U54NS081760 10/1/12-9/30/17; Funded as principal investigator on 1R01HL122658 12/1/2014-11/30/2018; Funded as co-investigator on NIDDK/ GHRI R01DK092317 10/1/12-9/30/16.

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  1. NONE

Research Support, Government Entities:

  1. The research study was funded by NHLBI/NIH, HHSN268201300028C, Minneapolis field center. I have been the Principal Investigator of the Minneapolis CARDIA clinic since 1994.

Research Support, Academic Entities:

  1. NONE

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  1. NONE

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Abstract

Objective: To examine the association between the American Heart Association (AHA) Life's Simple 7 (LS7) metric and brain structure.

Methods: We determined cardiovascular health (CVH) according to the AHA LS7, assigning 0, 1, or 2 points for meeting poor, intermediate, or ideal criteria for the 7 components (range 0–14) at baseline (aged 18–30 years in 1985–1986) and year 25 follow-up examination for 518 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) brain MRI substudy. Visit-based CVH score and average score was assessed in relation to percent of intracranial volume of normal tissue of the whole brain, gray matter, and white matter, and abnormal tissue volume of white matter at year 25 using multivariable linear, logistic, and quantile regression, after adjustment for age, sex, race, field center, educational attainment, and alcohol consumption.

Results: Mean percentage of whole brain volume, normal gray matter, and normal white matter was 81.3% (±2.5), 42.9% (±2.0), and 38.4% (±2.0). Greater CVH score at baseline (per each additional point at year 0: 0.1%, 95% confidence limits 0.01–0.3; p < 0.05) and average CVH score were associated with greater percentage of whole brain volume (per each additional point in average score: 0.2%, 95% confidence limits 0.04–0.3; p < 0.05). Visit-based or average CVH score was not significantly associated with normal gray or white matter volume or abnormal white matter volume.

Conclusions: Maintaining ideal levels of cardiovascular health, determined by the LS7, in young adulthood is associated with greater whole brain volume in middle age but not regional differences in structure.

  • Received December 12, 2016.
  • Accepted in final form May 26, 2017.
  1. Published online before print July 19, 2017, doi: 10.1212/WNL.0000000000004222 Neurology 10.1212/WNL.0000000000004222
  1. » Abstract
  2. Full Text (PDF)
  3. Data Supplement

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