DEDICATION:

Jiang-Fan Chen, Thomas Chase, and Michael Schwarzschild

J. Stephen Fink, MD, PhD (1950–2002)
Neurology 2003 61: 1. [Full Text] [Figures Only]  

INTRODUCTION:

Michael A. Schwarzschild, Jiang-Fan Chen, and Thomas N. Chase

A_2A antagonists for PD: A prime example of translational neuroscience
Neurology 2003 61: 3. [Full Text] [Figures Only] [Data Supplement]  

KEYNOTE ADDRESS:

Bertil B. Fredholm and Per Svenningsson

Adenosine–dopamine interactions: Development of a concept and some comments on therapeutic possibilities
Neurology 2003 61: 5. [Abstract] [Full Text] [Figures Only]  

I. THE BIOLOGY OF A2A RECEPTORS IN THE BASAL GANGLIA:

Per Svenningsson and Bertil B. Fredholm

Introduction: Exciting news about A_2A receptors
Neurology 2003 61: 10. [Full Text]  

Diane L. Rosin, Barbara D. Hettinger, Amy Lee, and Joel Linden

Anatomy of adenosine A_2A receptors in brain: Morphological substrates for integration of striatal function
Neurology 2003 61: 12. [Abstract] [Full Text] [Figures Only]  

K. Fuxe, L.F. Agnati, K. Jacobsen, J. Hillion, M. Canals, M. Torvinen, B. Tinner-Staines, W. Staines, D. Rosin, A. Terasmaa, P. Popoli, G. Leo, V. Vergoni, C. Lluis, F. Ciruela, R. Franco, and S. Ferré

Receptor heteromerization in adenosine A_2A receptor signaling: Relevance for striatal function and Parkinson’s disease
Neurology 2003 61: 19. [Abstract] [Full Text] [Figures Only]  

S.N. Schiffmann, D. Dassesse, P. d’Alcantara, C. Ledent, S. Swillens, and Michele Zoli

A_2A receptor and striatal cellular functions: Regulation of gene expression, currents, and synaptic transmission
Neurology 2003 61: 24. [Abstract] [Full Text] [Figures Only]  

II. A2A RECEPTOR MODULATION OF MOTOR SYSTEMS FOR SYMPTOMATIC THERAPY IN PD:

David G. Standaert

Introduction: Adenosine A_2A receptor modulation of motor systems for symptomatic therapy in Parkinson’s disease
Neurology 2003 61: 30. [Full Text]  

Peter Jenner

A_2A antagonists as novel non-dopaminergic therapy for motor dysfunction in PD
Neurology 2003 61: 32. [Abstract] [Full Text] [Figures Only]  

Anna R. Carta, Annalisa Pinna, Elisabetta Tronci, and Micaela Morelli

Adenosine A_2A and dopamine receptor interactions in basal ganglia of dopamine denervated rats
Neurology 2003 61: 39. [Abstract] [Full Text] [Figures Only]  

Akihisa Mori and Tomomi Shindou

Modulation of GABAergic transmission in the striatopallidal system by adenosine A_2A receptors: A potential mechanism for the antiparkinsonian effects of A_2A antagonists
Neurology 2003 61: 44. [Abstract] [Full Text] [Figures Only]  

III. A2A RECEPTORS IN NEUROPROTECTION OF DOPAMINERGIC NEURONS:

Felicita Pedata, Anna Maria Pugliese, Alessia Melani, and Marco Gianfriddo

Introduction: A_2A receptors in neuroprotection of dopaminergic neurons
Neurology 2003 61: 49. [Full Text]  

Alberto Ascherio and Honglei Chen

Caffeinated clues from epidemiology of Parkinson’s disease
Neurology 2003 61: 51. [Full Text] [Figures Only]  

Michael A. Schwarzschild, Kui Xu, Emin Oztas, Jacobus P. Petzer, Kay Castagnoli, Neal Castagnoli, Jr., and Jiang-Fan Chen

Neuroprotection by caffeine and more specific A_2A receptor antagonists in animal models of Parkinson’s disease
Neurology 2003 61: 55. [Abstract] [Full Text] [Figures Only]  

Neal Castagnoli, Jr., Jacobus P. Petzer, Salome Steyn, Kay Castagnoli, Jiang-Fan Chen, Michael A. Schwarzschild, and Cornelis J. Van der Schyf

Monoamine oxidase B inhibition and neuroprotection: Studies on selective adenosine A_2A receptor antagonists
Neurology 2003 61: 62. [Abstract] [Full Text] [Figures Only]  

P. Popoli, C. Frank, M.T. Tebano, R.L. Potenza, A. Pintor, M.R. Domenici, V. Nazzicone, A. Pèzzola, and R. Reggio

Modulation of glutamate release and excitotoxicity by adenosine A_2A receptors
Neurology 2003 61: 69. [Abstract] [Full Text] [Figures Only]  

IV. ADENOSINE A2A RECEPTORS IN NONLOCOMOTOR FEATURES OF PARKINSON'S DISEASE:

Ennio Ongini

Introduction: Adenosine A_2A receptors in nonlocomotor features of Parkinson’s disease: Introduction
Neurology 2003 61: 72. [Full Text]  

Jiang-Fan Chen, Silva Fredduzzi, Elena Bastia, Liqun Yu, Rosario Moratalla, Ennio Ongini, and Michael A. Schwarzschild

Adenosine A_2A receptors in neuroadaptation to repeated dopaminergic stimulation: Implications for the treatment of dyskinesias in Parkinson’s disease
Neurology 2003 61: 74. [Abstract] [Full Text] [Figures Only]  

Malika El Yacoubi, Jean Costentin, and Jean-Marie Vaugeois

Adenosine A_2A receptors and depression
Neurology 2003 61: 82. [Abstract] [Full Text] [Figures Only]  

Scott M. Weiss, Emma Whawell, Rebecca Upton, and Colin T. Dourish

Potential for antipsychotic and psychotomimetic effects of A_2A receptor modulation
Neurology 2003 61: 88. [Abstract] [Full Text] [Figures Only]  

Yoshihiro Urade, Naomi Eguchi, Wei-Min Qu, Mie Sakata, Zhi-Li Huang, Jiang-Fan Chen, Michael A. Schwarzschild, J. Stephen Fink, and Osamu Hayaishi

Minireview: Sleep regulation in adenosine A_2A receptor-deficient mice
Neurology 2003 61: 94. [Full Text] [Figures Only]  

V. TRANSLATIONAL PROGRESS IN PURSUIT OF THERAPEUTIC A2A ANTAGONISTS:

Hiroshi Kase

Industry forum: Progress in pursuit of therapeutic A_2A antagonists: The adenosine A_2A receptor selective antagonist KW6002: Research and development toward a novel nondopaminergic therapy for Parkinson’s disease
Neurology 2003 61: 97. [Abstract] [Full Text] [Figures Only]  

S.M. Weiss, K. Benwell, I.A. Cliffe, R.J. Gillespie, A.R. Knight, J. Lerpiniere, A. Misra, R.M. Pratt, D. Revell, R. Upton, and C.T. Dourish

Discovery of nonxanthine adenosine A_2A receptor antagonists for the treatment of Parkinson’s disease
Neurology 2003 61: 101. [Abstract] [Full Text] [Figures Only]  

T.N. Chase, F. Bibbiani, W. Bara-Jimenez, T. Dimitrova, and J.D. Oh-Lee

Translating A_2A antagonist KW6002 from animal models to parkinsonian patients
Neurology 2003 61: 107. [Abstract] [Full Text] [Figures Only]  

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