
Alzheimer's disease
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Aducanumab Resources
The US Food and Drug Administration (FDA) announced on June 7, 2021, the approval of aducanumab (Aduhelm). The drug was approved under the Accelerated Approval pathway, one of the alternative drug approval pathways.
In addition to our latest articles on Alzheimer disease, Neurology has included a list of aducanumab resources on this page to help our members stay informed on the current landscape of the new Alzheimer disease drug.
Featured Editorials and Viewpoints
Aducanumab: Making Sense of the Cents
Gregory S. Day, MD, MSc, MSCI, FAANInevitably, the assumptions that guide cost-effectiveness calculations for any one patient will be as diverse and unique as the patient in question. Thus, we must be prepared to guide our patients with early symptomatic AD in this decision-making process, helping them to weigh uncertain benefits, risks, and costs associated with the use of aducanumab and other forthcoming treatments for AD. [Read Article]
Practical Considerations in the Administration of Aducanumab for the Neurologist
Katherine Coerver, Melissa M Yu, Anelyssa D'Abreu, Marc Wasserman, Kavita NairThe decision by the FDA to approve aducanumab remains controversial and its administration will pose many challenges that will be new to neurologists, despite extensive experience with prior intravenous medications. [Read Article]
Decisions With Patients and Families Regarding Aducanumab in Alzheimer Disease, With Recommendations for Consent: AAN Position Statement
Winston Chiong, Benjamin David Tolchin, Richard J. Bonnie, et al.Neurologists, patients and families will face ethical challenges given the incomplete data available to guide aducanumab prescribing, the prospect of worrisome financial conflicts of interest, and the costs and practical burdens that using aducanumab will impose on patients and families. Neurologists facing these challenges will be guided best by established ethical principles that they can apply, in turn, to transparently counsel patients and their families. [Read Article]
Aducanumab for Dementia
Brian C. CallaghanIn contrast to the unknown and unlikely efficacy, aducanumab has known serious side effects and high costs. Given the large downsides and unclear and unlikely benefits, I strongly support ICER’s report that states that there is insufficient evidence to support approval of aducanumab without further studies. [Read Article]
Clinical Efficacy, Drug Safety and Surrogate Endpoints: Has Aducanumab Met All of Its Expectations?
Linda A. Hershey, Rawan Tarawneh...the patient and their caregivers need to understand that the clinical benefits of aducanumab are small and that more data will be needed in the future to determine whether these benefits are clinically or functionally meaningful to patients. [Read Article]
Aducanumab, Amyloid Lowering, and Slowing of Alzheimer Disease
Stephen Salloway, Jeffrey CummingsAducanumab opens a new era in AD research and care and provides a foundation for development of progressively better therapies. [Read Article]
Prescribing Aducanumab in the Face of Meager Efficacy and Real Risks
David S. Knopman, Joel S. PerlmutterOn the one hand, neurologists want to offer hope. Yet, aducanumab’s benefits are meager, if even present and there are non-trivial risks of side effects. [Read Article]
Aducanumab Podcasts
Latest Articles
- Research ArticleAlzheimer Disease and Epilepsy: A Mendelian Randomization StudyYi Fang, Xiaoli Si, Jiali Wang, et al.Neurology May 24, 2023
- Research ArticleAssociation of Chronic Kidney Disease With Plasma NfL and Other Biomarkers of Neurodegeneration: The H70 Birth Cohort Study in GothenburgAnna Dittrich, Nicholas J Ashton, Henrik Zetterberg, et al.Neurology May 24, 2023
- EditorialScientific, Ethical, and Practical Considerations for the Testing and Disclosure of Alzheimer Disease BiomarkersElizabeth A. McCusker, Clement T. LoyNeurology February 15, 2023
- Contemporary Issues in Practice, Education, & ResearchTesting for Alzheimer Disease Biomarkers and Disclosing Results Across the Disease ContinuumEmily A. Largent, Joshua D. Grill, Kyra O'Brien, et al.Neurology January 31, 2023
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AAN Aducanumab Resources
Dr. David E. Vaillancourt and Dr. Shannon Y. Chiu
► Watch
- Neurology PodcastDr. Stacey Clardy talks with Dr. Nico Dosenbach about topographic brain organization and redrawing the homunculus. May 25, 2023.Neurology, Journal, Podcast