Major depression in multiple sclerosis
A population-based perspective
Abstract
Objective: To determine the prevalence of major depression in multiple sclerosis (MS) in a population-based sample controlling for nonspecific illness effects.
Methods: This study used data from a large-scale national survey conducted in Canada: the Canadian Community Health Survey (CCHS). The analysis included 115,071 CCHS subjects who were 18 years or older at the time of data collection. The CCHS interview obtained self-reported diagnoses of MS and employed a brief predictive interview for major depression: the Composite International Diagnostic Interview Short Form for Major Depression. The 12-month period prevalence of major depression was estimated in subjects with and without MS and with and without other long-term medical conditions.
Results: The prevalence of major depression was elevated in persons with MS relative to those without MS and those reporting other conditions. The association persisted after adjustment for age and sex (adjusted odds ratio = 2.3, 95% CI 1.6 to 3.3). Major depression prevalence in MS for those in the 18- to 45-year age range was high at 25.7% (95% CI 15.6 to 35.7).
Conclusions: The prevalence of major depression in the population with MS is elevated. This elevation is not an artifact of selection bias and exceeds that associated with having one or more other long-term conditions.
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References
1.
Hader WJ, Elliot M, Ebers GC. Epidemiology of multiple sclerosis in London and Middlesex County, Ontario, Canada. Neurology . 1988; 38: 617–621.
2.
Svenson LW, Woodhead SE, Platt GH. Regional variations in the prevalence rates of multiple sclerosis in the province of Alberta, Canada. Neuroepidemiology . 1994; 13: 8–13.
3.
Hammond SR, McLeod JG, Millingen KS, et al. The epidemiology of multiple sclerosis in three Australian cities: Perth, Newcastle and Hobart. Brain . 1988; 111: 1–25.
4.
Leibowitz U, Alter M, Halpern L. Clinical studies of multiple sclerosis in Israel. III. Clinical course and prognosis related to age at onset. Neurology . 1964; 14: 926–932.
5.
Confavreux C, Aimard G, Devic M. Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients. Brain . 1980; 103: 281–300.
6.
Wynn DR, Rodriquez M, O’Fallon M, Kurland LT. A reappraisal of the epidemiology of multiple sclerosis in Olmstead County, Minnesota. Neurology . 1990; 40: 780–786.
7.
Patten SB, Metz LM, SPECTRIMS Study Group. Interferon beta1a and depression in secondary progressive MS: data from the SPECTRIMS Trial. Neurology . 2002; 59: 744–746.
8.
Wang JL, Reimer MA, Metz LM, Patten SB. Major depression and quality of life in individuals with multiple sclerosis. Int J Psychiatr Med . 2000; 30: 309–317.
9.
Feinstein A. An examination of suicidal intent in patients with multiple sclerosis. Neurology . 2002; 59: 674–678.
10.
Caine ED, Schwid SR. Multiple sclerosis, depression, and the risk of suicide. Neurology . 2002; 59: 662–663.
11.
Mohr DC, Goodkin DE, Likosky W, Gatto N, Baumann KA, Rudick RA. Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Arch Neurol . 1997; 54: 531–533.
12.
Schiffer RB, Caine ED, Bamford KA, Levy S. Depressive episodes in patients with multiple sclerosis. Am J Psychiatry . 1983; 140: 1498–1500.
13.
Minden SL, Orav J, Reich P. Depression in multiple sclerosis. Gen Hosp Psychiatry . 1987; 9: 426–434.
14.
Joffe RT, Lippert GP, Gray TA, Sawa G, Horvath Z. Mood disorders and multiple sclerosis. Arch Neurol . 1987; 44: 376–378.
15.
Sadovnick AD, Remick RA, Allen J, et al. Depression and multiple sclerosis. Neurology . 1996; 46: 628–632.
16.
Patten SB, Metz LM, Reimer MA. Biopsychosocial correlates of major depression in a multiple sclerosis population. Mult Scler . 2000; 6: 115–120.
17.
Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA . 2003; 289: 3095–3105.
18.
Wells KB, Golding JM, Burnam MA. Psychiatric disorder in a sample of the general population with and without chronic medical conditions. Am J Psychiatry . 1988; 145: 976–981.
19.
Patten SB. Long-term medical conditions and major depression in a Canadian population survey at waves 1 and 2. J Affect Disord . 2001; 63: 35–41.
20.
Schiffer RB, Babigian HM. Behavioral disorders in multiple sclerosis, temporal lobe epilepsy, and amyotrophic lateral sclerosis. Arch Neurol . 1984; 41: 1067–1069.
21.
Kessler RC, Andrews G, Mroczek D, Ustun B, Wittchen HU. The World Health Organization Composite International Diagnostic Interview Short-Form (CIDI-SF). Int J Methods Psychiatr Res . 1998; 7: 171–185.
22.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). Washington, DC: American Psychiatric Press, 2000.
23.
Patten SB, Brandon–Christie J, Devji J, Sedmak B. Performance of the Composite International Diagnostic Interview Short Form for major Depression in a community sample. Chron Dis Can . 2000; 21: 68–72.
24.
Furlong WJ, Feeny DH, Torrance GW, et al. Multiplicative multi-attribute utility function for the Health Utilities Index Mark 3 (HUI3) system: a technical report. McMaster University Centre for Health Economics and Policy Analysis working paper 98–11, 1998.
25.
Mazure CM, Maciejewski PK. A model of risk for major depression: effects of life stress and cognitive style vary by age. Depression Anxiety . 2003; 17: 26–33.
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Received: May 19, 2003
Accepted: August 20, 2003
Published online: December 8, 2003
Published in print: December 9, 2003
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