Influence of the amyloid precursor protein locus on dementia in Down syndrome
Abstract
Background: The amyloid precursor protein (APP) locus on chromosome 21 influences the development of Alzheimer disease.
Method: The authors investigated the relationship between a tetranucleotide repeat on intron 7 of the APP gene and the age at onset of dementia in Down syndrome (DS).
Results: There was a 13-year difference in the age at onset of dementia in DS associated with the number of tetranucleotide repeat alleles in APP.
Conclusion: APP is an important locus predicting the age at onset of dementia in people with Down syndrome.
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Publication History
Received: August 22, 2003
Accepted: March 22, 2004
Published online: June 7, 2004
Published in print: June 8, 2004
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