[123I]-FP-CIT-SPECT in the early diagnosis of PD presenting as exercise-induced dystonia
Abstract
Isolated foot dystonia following exercise is a rare manifestation of early PD. It may precede the onset of parkinsonism by years and can be clinically indistinguishable from familial exercise-induced dystonia. The authors present a patient with dystonic claudication where dopamine transporter SPECT using 123I-FP-CIT allowed early diagnosis of PD and enabled effective symptomatic treatment with a dopamine agonist.
Get full access to this article
View all available purchase options and get full access to this article.
References
1.
Purves Stewart J. Paralysis agitans with an account of a new symptom. Lancet . 1898; 2: 1258–1260.
2.
Lees AJ, Hardie RJ, Stern GM. Kinesigenic foot dystonia as a presenting feature of Parkinson’s disease. J Neurol Neurosurg Psychiatry . 1984; 47: 885.
3.
Booij J, Habraken JBA, Bergmans P, et al. Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson’s disease. J Nucl Med . 1998; 39: 1879–1884.
4.
Blunt SB, Richards PG, Khalil N. Foot dystonia and lumbar canal stenosis. Mov Disord . 1996; 11: 723–725.
5.
McCrory P. An unusual cause of gait disturbance in an elite sprinter. Mov Disord . 2000; 15: 176–177.
6.
Bhatia KP, Soland VL, Bhatt MH, Quinn NP, Marsden CD. Paroxysmal exercise induced dystonia: eight new sporadic cases and a review of the literature. Mov Disord . 1997; 12: 1007–1012.
7.
Demirkian M, Jankovic J. Paroxysmal dyskinesias: clinical features and classification. Ann Neurol . 1995; 38: 571–579.
8.
Poewe WH, Lees AJ. The pharmacology of foot dystonia in parkinsonism. Clin Neuropharmacol . 1987; 10: 47–56.
9.
LeWitt PA, Burns RS, Newman RP. Dystonia in untreated parkinsonism. Clin Neuropharmacol . 1986; 9: 293–297.
10.
Kitada T, Asakawa S, Hattori N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature . 1998; 392: 605–608.
Information & Authors
Information
Published In
Copyright
© 2002.
Publication History
Received: May 13, 2002
Accepted: August 19, 2002
Published online: December 24, 2002
Published in print: December 24, 2002
Authors
Metrics & Citations
Metrics
Citations
Download Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.
Cited By
- Paroxysmal dyskinesias, Principles and Practice of Movement Disorders, (560-578.e13), (2021).https://doi.org/10.1016/B978-0-323-31071-0.00024-X
- Billiards-related dystonia: A new task-specific dystonia, Parkinsonism & Related Disorders, 60, (10-11), (2019).https://doi.org/10.1016/j.parkreldis.2018.12.018
- Paroxysmal movement disorders: An update, Revue Neurologique, 172, 8-9, (433-445), (2016).https://doi.org/10.1016/j.neurol.2016.07.005
- Paroxysmal Dyskinesias, Hyperkinetic Movement Disorders, (145-163), (2012).https://doi.org/10.1007/978-1-60327-120-2_6
- The paroxysmal dyskinesias, Principles and Practice of Movement Disorders, (476-495), (2011).https://doi.org/10.1016/B978-1-4377-2369-4.00022-6
- Pain and Paresthesia in Parkinson's Disease, Parkinson's Disease, (315-332), (2011).https://doi.org/10.1002/9781444397970.ch29
- Dysregulation of striatal dopamine release in a mouse model of dystonia, Journal of Neurochemistry, 114, 6, (1781-1791), (2010).https://doi.org/10.1111/j.1471-4159.2010.06890.x
- GLUT1 gene mutations cause sporadic paroxysmal exercise‐induced dyskinesias, Movement Disorders, 24, 11, (1684-1688), (2009).https://doi.org/10.1002/mds.22507
- Commentary: Dopaminergic dysfunction in DYT1 dystonia, Experimental Neurology, 212, 2, (242-246), (2008).https://doi.org/10.1016/j.expneurol.2008.04.020
- The Paroxysmal Dyskinesias, Principles and Practice of Movement Disorders, (553-575), (2007).https://doi.org/10.1016/B978-0-443-07941-2.50026-7
- See more
Loading...
View Options
Login options
Check if you have access through your login credentials or your institution to get full access on this article.
Personal login Institutional LoginPurchase Options
The neurology.org payment platform is currently offline. Our technical team is working as quickly as possible to restore service.
If you need immediate support or to place an order, please call or email customer service:
- 1-800-638-3030 for U.S. customers - 8:30 - 7 pm ET (M-F)
- 1-301-223-2300 for customers outside the U.S. - 8:30 - 7 pm ET (M-F)
- [email protected]
We appreciate your patience during this time and apologize for any inconvenience.