Double dissociation of social functioning in frontotemporal dementia
Abstract
Background: Efforts to characterize changes in social functioning in frontotemporal dementia (FTD) have failed to elicit clear dissociation between frontal and temporal variants of the disease based on behavioral measures.
Methods: This study obtained premorbid and current first-degree relative ratings using an established measure of interpersonal functioning, the Interpersonal Adjectives Scales, to measure personality change in 16 patients with frontal variant (FLV) and 13 with temporal variant (TLV) FTD, and in a control group of 16 patients with AD.
Results: All three groups showed significant change over time in multiple domains, including increased introversion (FG) and submissiveness (HI). However, patients with both FTD subtypes evidenced significantly greater increases in overall interpersonal pathology vector length [VL] than did patients with AD, who remained within the normal range on all scores. Patients with FLV showed a 2 SD increase in submissiveness (HI), but their cold-heartedness (DE) change scores were not significantly different from those of patients with AD. Conversely, the TLV cold-heartedness (DE) score increased 2 SD compared to minimal change for the AD and FLV groups, yet change in submissiveness (HI) did not differentiate between AD and TLV groups.
Conclusions: The Interpersonal Adjectives Scales differentiated both FTD groups from patients with AD on the basis of both degree and direction of personality change. Also, the two subtypes of FTD showed distinctly different patterns of change in social functioning: patients with temporal variant shifted toward severe interpersonal coldness with mild loss of dominance, whereas patients with frontal variant showed the opposite pattern.
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References
1.
Brun A, Englund B, Gustafson L, et al. Clinical and neuropathological criteria for frontotemporal dementia. J Neurol Neurosurg Psychiatry . 1994; 57: 416–418.
2.
Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology . 1998; 51: 1546–1554.
3.
Edwards-Lee T, Miller BL, Benson DF, et al. The temporal variant of frontotemporal dementia. Brain . 1997; 120: 1027–1040.
4.
Gregory CA, Hodges JR. Dementia of frontal type and the focal lobar atrophies. Int Rev Psychiatry . 1993; 5: 397–406.
5.
Bozeat S, Gregory CA, Ralph MA, Hodges JR. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer’s disease? J Neurol Neurosurg Psychiatry . 2000; 69: 178–186.
6.
Costa PT Jr, McCrae RR. Personality in adulthood: a six-year longitudinal study of self-reports and spouse ratings on the NEO Personality Inventory. J Pers Soc Psychol . 1988; 54: 853–863.
7.
Costa PT, McCrae RR. Normal personality assessment in clinical practice: The NEO Personality Inventory. Psychological Assessment . 1992; 4: 39–53.
8.
Digman JM. Personality structure: emergence of the five-factor model. Annu Rev Psychol . 1990; 41: 417–440.
9.
Stuss DT, Benson DF. The frontal lobes. New York: Raven Press, 1986.
10.
Strauss ME, Pasupathi M, Chatterjee A. Concordance between observers in descriptions of personality change in Alzheimer’s disease. Psychol Aging . 1993; 8: 475–480.
11.
Siegler IC, Dawson DV, Welsh KA. Caregiver ratings of personality change in Alzheimer’s disease patients: a replication. Psychol Aging . 1994; 9: 464–466.
12.
Chatterjee A, Strauss M, Smyth KA, Whitehouse PJ. Personality changes in Alzheimer’s disease. Arch Neurol . 1992; 49: 486–491.
13.
Rosen HJ, Gorno-Tempini ML, Goldman WP, et al. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology . 2002; 58: 198–208.
14.
McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology . 1984; 34: 939–944.
15.
Wiggins JS. Interpersonal Adjectives Scale. Professional manual. Odessa, FL: Psychological Assessment Resources, 1995.
16.
Wiggins JS, Trapnell P, Phillips N. Psychometric and geometric characteristics of the Revised Interpersonal Adjective Scales (IAS–R). Multivariate Behavioral Research . 1988; 23: 1–59.
17.
Heinik J, Keren P, Vainer-Benaiah Z, Lahav D, Bleich A. Agreement between spouses and children in descriptions of personality change in Alzheimer’s disease. Isr J Psychiatry Relat Sci . 1999; 36: 88–94.
18.
Kurtz JE, Lee PA, Sherker JL. Internal and temporal reliability estimates for informant ratings of personality using the NEO-PI-R and IAS. Assessment . 1999; 6: 103–113.
19.
Wiggins JS, Coutu J. Interpersonal Adjective Scales (IAS) scoring program [computer software]. Odessa, FL: Psychological Assessment Resources, 1995.
20.
Perry RJ, Rosen HR, Kramer JH, et al. Hemispheric dominance for emotions, empathy and social behaviour: evidence from right and left handers with frontotemporal dementia. Neurocase . 2001; 7: 145–160.
21.
Damasio AR, Tranel D, Damasio H. Face agnosia and the neural substrates of memory. Annu Rev Neurosci . 1990; 13: 89–109.
22.
Adolphs R. Social cognition and the human brain. Trends Cogn Sci . 1999; 3: 469–479.
23.
Allison T, Puce A, McCarthy G. Social perception from visual cues: role of the STS region. Trends Cogn Sci . 2000; 4: 267–278.
24.
Reiman EM. The application of positron emission tomography to the study of normal and pathologic emotions. J Clin Psychiatry . 1997; 58 (suppl 16): 4–12.
25.
Franzen EA, Myers RE. Neural control of social behavior: prefrontal and anterior temporal cortex. Neuropsychologia . 1973; 11: 141–157.
26.
Miller BL, Seeley WW, Mychack P, et al. Neuroanatomy of the self: evidence from patients with frontotemporal dementia. Neurology . 2001; 57: 817–821.
27.
Shammi P, Stuss DT. Humour appreciation: a role of the right frontal lobe. Brain . 1999; 122: 657–666.
28.
Borod JC, Cicero BA, Obler LK, et al. Right hemisphere emotional perception: evidence across multiple channels. Neuropsychology . 1998; 12: 446–458.
29.
Blair RJR, Cipolotti L. Impaired social response reversal: a case of ’acquired sociopathy. Brain . 2000; 123: 1122–1141.
30.
Miller BL, Chang L, Mena I, Boone K, Lesser IM. Progressive right frontotemporal degeneration: clinical, neuropsychological and SPECT characteristics. Dementia . 1993; 4: 204–213.
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Received: October 18, 2001
Accepted: September 15, 2002
Published online: January 28, 2003
Published in print: January 28, 2003
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