Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy
Abstract
MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.
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Published In
Neurology®
Volume 63 • Number 5 • September 14, 2004
Pages: 897-900
Copyright
© 2004.
Publication History
Received: February 3, 2004
Accepted: April 20, 2004
Published online: September 13, 2004
Published in print: September 14, 2004
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