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December 28, 2004

Etanercept treatment in corticosteroid-dependent myasthenia gravis

December 28, 2004 issue
63 (12) 2390-2392

Abstract

The authors report a prospective pilot trial of etanercept in corticosteroid-dependent autoimmune myasthenia gravis. Eleven patients were enrolled, with eight completing the 6-month trial. Two patients were withdrawn owing to disease worsening, and one patient was withdrawn because of an erythematous skin rash. Six of the eight patients who completed the trial improved, based on quantitative measures of muscle strength and lowering of corticosteroid requirement.

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Information & Authors

Information

Published In

Neurology®
Volume 63Number 12December 28, 2004
Pages: 2390-2392
PubMed: 15623708

Publication History

Received: May 11, 2004
Accepted: August 2, 2004
Published online: December 28, 2004
Published in print: December 28, 2004

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Authors

Affiliations & Disclosures

J. Rowin, MD
From the Section of Neuromuscular Disease (Drs. Rowin and Meriggioli), Department of Neurology and Rehabilitation, University of Illinois at Chicago, and Department of Neurological Sciences (Dr. Leurgans), Rush University Medical Center, Chicago, IL, and Department of Microbiology and Immunology (Drs. Tüzün and Christadoss), University of Texas at Galveston.
M. N. Meriggioli, MD
From the Section of Neuromuscular Disease (Drs. Rowin and Meriggioli), Department of Neurology and Rehabilitation, University of Illinois at Chicago, and Department of Neurological Sciences (Dr. Leurgans), Rush University Medical Center, Chicago, IL, and Department of Microbiology and Immunology (Drs. Tüzün and Christadoss), University of Texas at Galveston.
E. Tüzün, MD
From the Section of Neuromuscular Disease (Drs. Rowin and Meriggioli), Department of Neurology and Rehabilitation, University of Illinois at Chicago, and Department of Neurological Sciences (Dr. Leurgans), Rush University Medical Center, Chicago, IL, and Department of Microbiology and Immunology (Drs. Tüzün and Christadoss), University of Texas at Galveston.
S. Leurgans, PhD
From the Section of Neuromuscular Disease (Drs. Rowin and Meriggioli), Department of Neurology and Rehabilitation, University of Illinois at Chicago, and Department of Neurological Sciences (Dr. Leurgans), Rush University Medical Center, Chicago, IL, and Department of Microbiology and Immunology (Drs. Tüzün and Christadoss), University of Texas at Galveston.
P. Christadoss, MD
From the Section of Neuromuscular Disease (Drs. Rowin and Meriggioli), Department of Neurology and Rehabilitation, University of Illinois at Chicago, and Department of Neurological Sciences (Dr. Leurgans), Rush University Medical Center, Chicago, IL, and Department of Microbiology and Immunology (Drs. Tüzün and Christadoss), University of Texas at Galveston.

Notes

Address correspondence and reprint requests to Dr. M.N. Meriggioli, Section of Neuromuscular Disease, Department of Neurology and Rehabilitation, University of Illinois at Chicago, 912 S. Wood St., 855N NPI, M/C 796, Chicago, IL 60612-7330; e-mail: [email protected]

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