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August 22, 2005

rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease

August 23, 2005 issue
65 (4) 623-625

Abstract

The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.

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Information & Authors

Information

Published In

Neurology®
Volume 65Number 4August 23, 2005
Pages: 623-625
PubMed: 16116131

Publication History

Published online: August 22, 2005
Published in print: August 23, 2005

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Authors

Affiliations & Disclosures

G. Koch, MD
From the Fondazione Santa Lucia IRCCS (Drs. Koch, Brusa, Caltagirone, Peppe, Oliveri, Stanzione, and Centonze), Rome, Clinica Neurologica (Drs. Koch, Brusa, Caltagirone, Stanzione, and Centonze), Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, and Dipartimento di Psicologia (Dr. Oliveri), Università di Palermo, Italy.
L. Brusa, MD
From the Fondazione Santa Lucia IRCCS (Drs. Koch, Brusa, Caltagirone, Peppe, Oliveri, Stanzione, and Centonze), Rome, Clinica Neurologica (Drs. Koch, Brusa, Caltagirone, Stanzione, and Centonze), Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, and Dipartimento di Psicologia (Dr. Oliveri), Università di Palermo, Italy.
C. Caltagirone, MD
From the Fondazione Santa Lucia IRCCS (Drs. Koch, Brusa, Caltagirone, Peppe, Oliveri, Stanzione, and Centonze), Rome, Clinica Neurologica (Drs. Koch, Brusa, Caltagirone, Stanzione, and Centonze), Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, and Dipartimento di Psicologia (Dr. Oliveri), Università di Palermo, Italy.
A. Peppe, MD
From the Fondazione Santa Lucia IRCCS (Drs. Koch, Brusa, Caltagirone, Peppe, Oliveri, Stanzione, and Centonze), Rome, Clinica Neurologica (Drs. Koch, Brusa, Caltagirone, Stanzione, and Centonze), Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, and Dipartimento di Psicologia (Dr. Oliveri), Università di Palermo, Italy.
M. Oliveri, MD
From the Fondazione Santa Lucia IRCCS (Drs. Koch, Brusa, Caltagirone, Peppe, Oliveri, Stanzione, and Centonze), Rome, Clinica Neurologica (Drs. Koch, Brusa, Caltagirone, Stanzione, and Centonze), Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, and Dipartimento di Psicologia (Dr. Oliveri), Università di Palermo, Italy.
P. Stanzione, MD
From the Fondazione Santa Lucia IRCCS (Drs. Koch, Brusa, Caltagirone, Peppe, Oliveri, Stanzione, and Centonze), Rome, Clinica Neurologica (Drs. Koch, Brusa, Caltagirone, Stanzione, and Centonze), Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, and Dipartimento di Psicologia (Dr. Oliveri), Università di Palermo, Italy.
D. Centonze, MD
From the Fondazione Santa Lucia IRCCS (Drs. Koch, Brusa, Caltagirone, Peppe, Oliveri, Stanzione, and Centonze), Rome, Clinica Neurologica (Drs. Koch, Brusa, Caltagirone, Stanzione, and Centonze), Dipartimento di Neuroscienze, Università di Tor Vergata, Rome, and Dipartimento di Psicologia (Dr. Oliveri), Università di Palermo, Italy.

Notes

Address correspondence and reprint requests to Dr. G. Koch, Fondazione Santa Lucia, IRCCS, Laboratorio di Neurologia Clinica e Comportamentale, Via Ardeatina 306, 00179 Roma, Italy; e-mail: [email protected].

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Cited By
  1. Neuroplasticity in levodopa-induced dyskinesias: An overview on pathophysiology and therapeutic targets, Progress in Neurobiology, 232, (102548), (2024).https://doi.org/10.1016/j.pneurobio.2023.102548
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  2. Comparative efficacy of transcranial magnetic stimulation on different targets in Parkinson’s disease: A Bayesian network meta-analysis, Frontiers in Aging Neuroscience, 14, (2023).https://doi.org/10.3389/fnagi.2022.1073310
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  3. Effects of non-invasive brain stimulation over supplementary motor area in people with Parkinson’s disease: a protocol for a systematic review and meta-analysis of randomised controlled trials, BMJ Open, 13, 12, (e076948), (2023).https://doi.org/10.1136/bmjopen-2023-076948
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  4. The Supplementary Motor Complex in Parkinson’s Disease, Journal of Movement Disorders, 15, 1, (21-32), (2022).https://doi.org/10.14802/jmd.21075
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  5. Effects of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Parkinson’s Disease: A Meta-Analysis, Neurorehabilitation and Neural Repair, 36, 7, (395-404), (2022).https://doi.org/10.1177/15459683221095034
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  6. Corticocortical paired associative stimulation for treating motor dysfunction after stroke: study protocol for a randomised sham-controlled double-blind clinical trial, BMJ Open, 12, 1, (e053991), (2022).https://doi.org/10.1136/bmjopen-2021-053991
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  7. Therapeutic application of rTMS in neurodegenerative and movement disorders: A review, Journal of Electromyography and Kinesiology, 62, (102622), (2022).https://doi.org/10.1016/j.jelekin.2021.102622
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  8. Noninvasive neuromodulation in Parkinson's disease: Neuroplasticity implication and therapeutic perspectives, Neuroplasticity - From Bench to Bedside, (185-198), (2022).https://doi.org/10.1016/B978-0-12-819410-2.00010-2
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  9. Plasticity, genetics, and epigenetics in l-dopa-induced dyskinesias, Neuroplasticity - From Bench to Bedside, (167-184), (2022).https://doi.org/10.1016/B978-0-12-819410-2.00009-6
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  10. Downregulation of CD73/A2AR-Mediated Adenosine Signaling as a Potential Mechanism of Neuroprotective Effects of Theta-Burst Transcranial Magnetic Stimulation in Acute Experimental Autoimmune Encephalomyelitis, Brain Sciences, 11, 6, (736), (2021).https://doi.org/10.3390/brainsci11060736
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