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February 13, 2006

Silent microbleeds are associated with volume of primary intracerebral hemorrhage

February 14, 2006 issue
66 (3) 430-432

Abstract

The authors performed a correlative radiologic study on the micro-bleeds and volume of intracerebral hemorrhage in the supratentorial ICH patients. In the patients with lobar or putaminal hemorrhage, the hemorrhage volumes increased more than twofold or threefold in the patients with micro-bleeds. Moreover, the presence of microbleeds was an independent risk factor for large-sized hemorrhage. These data show that microbleeds may be associated with a larger ICH volume.

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References

1.
Lee SH, Bae HJ, Yoon BW, Kim H, Kim DE, Roh JK. Low concentration of serum total cholesterol is associated with multifocal signal loss lesions on gradient-echo magnetic resonance imaging: analysis of risk factors for multifocal signal loss lesions. Stroke 2002;33:2845–2849.
2.
Lee SH, Park JM, Kwon SJ, et al. Left ventricular hypertrophy is associated with cerebral microbleeds in hypertensive patients. Neurology 2004;63:16–21.
3.
Lee SH, Bae HJ, Kwon SJ, et al. Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology 2004;62:72–76.
4.
Lee SH, Kwon SJ, Kim KS, Yoon BW, Roh JK. Cerebral microbleeds in patients with hypertensive stroke: topographical distribution in the supratentorial area. J Neurol 2004;251:1183–1189.
5.
Fan YH, Zhang L, Lam WW, Mok VC, Wong KS. Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke 2003;34:2459–2462.
6.
Fisher CM. Pathological observations in hypertensive cerebral hemorrhage. J Neuropathol Exp Neurol 1971;30:536–550.
7.
Alvarez-Sabin J, Delgado P, Abilleira S, et al. Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome. Stroke 2004;35:1316–1322.
8.
Aoki T, Sumii T, Mori T, Wang X, Lo EH. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Stroke 2002;33:2711–2717.
9.
Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999;20:637–642.
10.
Tanaka A, Ueno Y, Nakayama Y, Takano K, Takebayashi S. Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas. Stroke 1999;30:1637–1642.

Information & Authors

Information

Published In

Neurology®
Volume 66Number 3February 14, 2006
Pages: 430-432
PubMed: 16476948

Publication History

Published online: February 13, 2006
Published in print: February 14, 2006

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Authors

Affiliations & Disclosures

Seung-Hoon Lee, MD
From the Department of Neurology; Neuroscience Research Institute, SNUMRC and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Beom Joon Kim, MD
From the Department of Neurology; Neuroscience Research Institute, SNUMRC and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Jae-Kyu Roh, MD, PhD
From the Department of Neurology; Neuroscience Research Institute, SNUMRC and Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.

Notes

Address correspondence and reprint requests to Dr. Jae-Kyu Roh, Department of Neurology, Seoul National University Hospital, 28 Yongon-dong, Jongno-gu, Seoul, 110-744, Republic of Korea; e-mail: [email protected]

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  3. Subsequent bilateral intracerebral hemorrhages in the putamen and thalamus: A report of four cases, Surgical Neurology International, 13, (403), (2022).https://doi.org/10.25259/SNI_440_2022
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  9. Microsanguinamenti intracerebrali, EMC - Neurologia, 19, 3, (1-9), (2019).https://doi.org/10.1016/S1634-7072(19)42493-8
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