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October 9, 2006

Warfarin vs aspirin for symptomatic intracranial stenosis: Subgroup analyses from WASID

S. E. Kasner, MD, M. J. Lynn, MS, M. I. Chimowitz, MB, ChB, M. R. Frankel, MD, H. Howlett-Smith, RN, V. S. Hertzberg, PhD, S. Chaturvedi, MD, … Show All … , S. R. Levine, MD, B. J. Stern, MD, C. G. Benesch, MD, T. G. Jovin, MD, C. A. Sila, MD, J. G. Romano, MD, and for the Warfarin Aspirin Symptomatic Intracranial Disease (WASID) Trial InvestigatorsAuthors Info & Affiliations
October 10, 2006 issue
67 (7) 1275-1278
https://doi.org/10.1212/01.wnl.0000238506.76873.2f
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Abstract

The WASID trial showed no advantage of warfarin over aspirin for preventing the primary endpoint of ischemic stroke, brain hemorrhage, or vascular death. In analyses of selected subgroups, there was no definite benefit from warfarin. Warfarin reduced the risk of the primary endpoint among patients with basilar artery stenosis, but there was no reduction in stroke in the basilar artery territory or benefit for vertebral artery stenosis or posterior circulation disease in general.

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References

1.
Chimowitz MI, Lynn MJ, Howlett-Smith H, et al. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. N Engl J Med 2005;352:1305–1316.
Crossref
PubMed
Google Scholar
2.
Chimowitz MI, Kokkinos J, Strong J, et al. The Warfarin-Aspirin Symptomatic Intracranial Disease Study. Neurology 1995;45:1488–1493.
Crossref
PubMed
Google Scholar
3.
Browne TR 3rd, Poskanzer DC. Treatment of strokes. I. N Engl J Med 1969;281:594–602.
Crossref
PubMed
Google Scholar
4. discussion 1039–1040.
Qureshi AI, Ziai WC, Yahia AM, et al. Stroke-free survival and its determinants in patients with symptomatic vertebrobasilar stenosis: a multicenter study. Neurosurgery 2003;52(5):1033–1039;
Google Scholar
5.
Thijs VN, Albers GW. Symptomatic intracranial atherosclerosis: outcome of patients who fail antithrombotic therapy. Neurology 2000;55:490–497.
Crossref
PubMed
Google Scholar
6.
The Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators. Design, progress and challenges of a double-blind trial of warfarin versus aspirin for symptomatic intracranial arterial stenosis. Neuroepidemiology 2003;22:106–117.
Crossref
PubMed
Google Scholar
7.
Assmann SF, Pocock SJ, Enos LE, Kasten LE. Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet 2000;355:1064–1069.
Crossref
PubMed
Google Scholar
8.
Perneger TV. What’s wrong with Bonferroni adjustments. BMJ 1998;316:1236–1238.
Crossref
PubMed
Google Scholar
9.
Freemantle N. Interpreting the results of secondary end points and subgroup analyses in clinical trials: should we lock the crazy aunt in the attic? BMJ 2001;322:989–991.
Crossref
PubMed
Google Scholar
10.
Koroshetz WJ. Warfarin, aspirin, and intracranial vascular disease. N Engl J Med 2005;352:1368–1370.
Crossref
PubMed
Google Scholar

Information & Authors

Information

Published In

Neurology®
Volume 67 • Number 7 • October 10, 2006
Pages: 1275-1278
PubMed: 17030766

Copyright

© 2006.

Publication History

Published online: October 9, 2006
Published in print: October 10, 2006

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Authors

Affiliations & Disclosures

S. E. Kasner, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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M. J. Lynn, MS
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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M. I. Chimowitz, MB, ChB
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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M. R. Frankel, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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H. Howlett-Smith, RN
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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V. S. Hertzberg, PhD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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S. Chaturvedi, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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S. R. Levine, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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B. J. Stern, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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C. G. Benesch, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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T. G. Jovin, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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C. A. Sila, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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J. G. Romano, MD
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.
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for the Warfarin Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators
From the Department of Neurology (S.E.K.), University of Pennsylvania Medical Center, Philadelphia, PA; Department of Biostatistics (M.J.L., V.S.H.), Rollins School of Public Health, Emory University, Atlanta, GA; Department of Neurology (M.I.C., M.R.F., H.-H.S., B.J.S.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.C.), Wayne State University, Detroit, MI; Department of Neurology (S.R.L.), Mt. Sinai School of Medicine, New York, NY; Department of Neurology (B.J.S.), University of Maryland, Baltimore, MD; Department of Neurology (C.G.B.), University of Rochester School of Medicine, Rochester, NY; Department of Neurology (T.G.J.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Department of Neurology (C.A.S.), Cleveland Clinic Foundation, Cleveland, OH; Department of Neurology (J.G.R.), University of Miami Medical School, Miami, FL.

Notes

Address correspondence and reprint requests to Dr. Scott E. Kasner, Department of Neurology, University of Pennsylvania, 3 W Gates Building, 3400 Spruce Street, Philadelphia, PA 19104; e-mail: [email protected]

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