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November 27, 2006

Prediction of thrombolytic efficacy in acute ischemic stroke using thin-section noncontrast CT

November 28, 2006 issue
67 (10) 1846-1848

Abstract

Thin-section noncontrast CT (NCT) can detect thrombi in large arteries and can provide a measure of thrombus composition based on Hounsfield Units (HU). A study using polyethylene tubes as a model of intracranial arteries concluded that the HUs of platelet-rich thrombi are lower than those of erythrocyte-rich thrombi. Thrombus HUs were measured by NCT in 34 patients with acute ischemic stroke before thrombolysis. Thrombi with lower HU counts were resistant to thrombolytics.

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Information & Authors

Information

Published In

Neurology®
Volume 67Number 10November 28, 2006
Pages: 1846-1848
PubMed: 17130421

Publication History

Published online: November 27, 2006
Published in print: November 28, 2006

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Authors

Affiliations & Disclosures

E. Y. Kim, MD
From the Department of Radiology, Research Institute of Radiologic Science (E.Y.K., S-K.L., D.J.K., S-H.S., J.K., D.I.K.) and Department of Neurology (J.H.H.), Yonsei University College of Medicine, Seoul, Korea.
J. H. Heo, MD
From the Department of Radiology, Research Institute of Radiologic Science (E.Y.K., S-K.L., D.J.K., S-H.S., J.K., D.I.K.) and Department of Neurology (J.H.H.), Yonsei University College of Medicine, Seoul, Korea.
S-K Lee, MD
From the Department of Radiology, Research Institute of Radiologic Science (E.Y.K., S-K.L., D.J.K., S-H.S., J.K., D.I.K.) and Department of Neurology (J.H.H.), Yonsei University College of Medicine, Seoul, Korea.
D. J. Kim, MD
From the Department of Radiology, Research Institute of Radiologic Science (E.Y.K., S-K.L., D.J.K., S-H.S., J.K., D.I.K.) and Department of Neurology (J.H.H.), Yonsei University College of Medicine, Seoul, Korea.
S-H Suh, MD
From the Department of Radiology, Research Institute of Radiologic Science (E.Y.K., S-K.L., D.J.K., S-H.S., J.K., D.I.K.) and Department of Neurology (J.H.H.), Yonsei University College of Medicine, Seoul, Korea.
J. Kim, MD
From the Department of Radiology, Research Institute of Radiologic Science (E.Y.K., S-K.L., D.J.K., S-H.S., J.K., D.I.K.) and Department of Neurology (J.H.H.), Yonsei University College of Medicine, Seoul, Korea.
D. I. Kim, MD
From the Department of Radiology, Research Institute of Radiologic Science (E.Y.K., S-K.L., D.J.K., S-H.S., J.K., D.I.K.) and Department of Neurology (J.H.H.), Yonsei University College of Medicine, Seoul, Korea.

Notes

Address correspondence and reprint requests to Dr. Eung Y. Kim, Department of Radiology and Research Institute of Radiological Sciences, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea; e-mail: [email protected]

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  1. Estimating Thrombus Elasticity by Shear Wave Elastography to Evaluate Ultrasound Thrombolysis for Thrombus With Different Stiffness, IEEE Transactions on Biomedical Engineering, 70, 1, (135-143), (2023).https://doi.org/10.1109/TBME.2022.3186586
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  2. Efficacy of thrombus density on noninvasive computed tomography neuroimaging for predicting thrombus pathology and patient outcome after mechanical thrombectomy in acute ischemic stroke, Asian Journal of Neurosurgery, 14, 03, (795-800), (2022).https://doi.org/10.4103/ajns.AJNS_238_18
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  3. Fibrin-Targeted Nanoparticles for Finding, Visualizing and Characterizing Blood Clots in Acute Ischemic Stroke, Pharmaceutics, 14, 10, (2156), (2022).https://doi.org/10.3390/pharmaceutics14102156
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  5. Associations between early ischemic signs on non-contrast CT and time since acute ischemic stroke onset: A scoping review, European Journal of Radiology, 155, (110455), (2022).https://doi.org/10.1016/j.ejrad.2022.110455
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  6. Radiology-Pathology Correlations of Intracranial Clots: Current Theories, Clinical Applications, and Future Directions, American Journal of Neuroradiology, 42, 9, (1558-1565), (2021).https://doi.org/10.3174/ajnr.A7249
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  7. Lysis of arterial thrombi by perfusion of N,N’-Diacetyl-L-cystine (DiNAC), PLOS ONE, 16, 2, (e0247496), (2021).https://doi.org/10.1371/journal.pone.0247496
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  8. Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization, European Stroke Journal, 6, 3, (254-261), (2021).https://doi.org/10.1177/23969873211024777
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  9. Heterogeneity between proximal and distal aspects of occlusive thrombi on pretreatment imaging in acute ischemic stroke, The Neuroradiology Journal, 35, 3, (378-387), (2021).https://doi.org/10.1177/19714009211049713
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  10. Characterization of thrombus composition with multimodality CT-based imaging: an in-vitro study, Journal of NeuroInterventional Surgery, 13, 8, (738-740), (2020).https://doi.org/10.1136/neurintsurg-2020-016799
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