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January 10, 2007

Evaluation of LRRK2 G2019S penetrance
Relevance for genetic counseling in Parkinson disease

S. Goldwurm, MD, PhD, M. Zini, MD, L. Mariani, MD, PhD, S. Tesei, MD, R. Miceli, PhD, F. Sironi, M. Clementi, V. Bonifati, MD, PhD, and G. Pezzoli, MDAuthors Info & Affiliations
April 3, 2007 issue
68 (14) 1141-1143
https://doi.org/10.1212/01.wnl.0000254483.19854.ef
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Abstract

We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.

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Information & Authors

Information

Published In

Neurology®
Volume 68 • Number 14 • April 3, 2007
Pages: 1141-1143
PubMed: 17215492

Copyright

© 2007.

Publication History

Published online: January 10, 2007
Published in print: April 3, 2007

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Authors

Affiliations & Disclosures

S. Goldwurm, MD, PhD
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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M. Zini, MD
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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L. Mariani, MD, PhD
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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S. Tesei, MD
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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R. Miceli, PhD
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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F. Sironi
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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M. Clementi
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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V. Bonifati, MD, PhD
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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G. Pezzoli, MD
From Istituti Clinici di Perfezionamento (S.G., M.Z., S.T., F.S., G.P.), Parkinson Institute-Milan; Unit of Medical Statistics and Biometry (L.M., R.M.), Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan; Molecular Genetics Laboratory (F.S.), Foundation “Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena,” Milan; Clinical Genetic Service (M.C.), Department of Pediatrics, University of Padova, Italy; and Department of Clinical Genetics (V.B.), Erasmus MC Rotterdam, The Netherlands.
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Notes

Address correspondence and reprint requests to Dr. Stefano Goldwurm, Parkinson Institute, Istituti Clinici di Perfezionamento, Via Bignami 1, 20126 Milan, Italy; e-mail: [email protected]

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