Articles
March 12, 2008
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease
K. Haugarvoll, MD, R. Rademakers, PhD, J. M. Kachergus, BSc, K. Nuytemans, MSc, O. A. Ross, PhD, J. M. Gibson, MD, E-K Tan, MD, … Show All … , C. Gaig, MD, E. Tolosa, MD, S. Goldwurm, MD, M. Guidi, MD, G. Riboldazzi, MD, L. Brown, BSc, U. Walter, MD, R. Benecke, MD, D. Berg, MD, T. Gasser, MD, J. Theuns, PhD, P. Pals, MD, P. Cras, MD, P. Paul De Deyn, MD, S. Engelborghs, MD, B. Pickut, MD, R. J. Uitti, MD, T. Foroud, PhD, W. C. Nichols, PhD, J. Hagenah, MD, C. Klein, MD, A. Samii, MD, C. P. Zabetian, MD, V. Bonifati, MD, PhD, C. Van Broeckhoven, PhD, M. J. Farrer, PhD, and Z. K. Wszolek, MD Show FewerAuthors Info & Affiliations
Abstract
Objective: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of Parkinson disease (PD). Several dominantly inherited pathogenic substitutions have been identified in different domains of the Lrrk2 protein. Herein, we characterize the clinical and genetic features associated with Lrrk2 p.R1441C.
Methods: We identified 33 affected and 15 unaffected LRRK2 c.4321C>T (p.R1441C) mutation carriers through an international consortium originating from three continents. The age-specific cumulative incidence of PD was calculated by Kaplan-Meier analysis.
Results: The clinical presentation of Lrrk2 p.R1441C carriers was similar to sporadic PD and Lrrk2 p.G2019S parkinsonism. The mean age at onset for parkinsonism was 60 years, range 30–79 years; fewer than 20% of the patients had symptoms before the age 50 years, while by 75 years >90% of them had developed symptoms. Haplotype analysis suggests four independent founders for the p.R1441C mutation.
Conclusions: The distribution in age at onset and clinical features in Lrrk2 p.R1441C patients are similar to idiopathic and Lrrk2 p.G2019S parkinsonism. Several independent founders of the p.R1441C substitution suggest this site is prone to recurrent mutagenesis.
GLOSSARY: COR = C-terminal of Roc; GTPase = guanosine triphosphatase; LBD = Lewy body disease; PD = Parkinson disease; SNPs = single nucleotide polymorphisms.
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Published online: March 12, 2008
Published in print: April 15, 2008
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K. Haugarvoll, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
R. Rademakers, PhD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
J. M. Kachergus, BSc
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
K. Nuytemans, MSc
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
O. A. Ross, PhD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
J. M. Gibson, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
E-K Tan, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
C. Gaig, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
E. Tolosa, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
S. Goldwurm, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
M. Guidi, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
G. Riboldazzi, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
L. Brown, BSc
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
U. Walter, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
R. Benecke, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
D. Berg, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
T. Gasser, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
J. Theuns, PhD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
P. Pals, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
P. Cras, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
P. Paul De Deyn, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
S. Engelborghs, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
B. Pickut, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
R. J. Uitti, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
T. Foroud, PhD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
W. C. Nichols, PhD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
J. Hagenah, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
C. Klein, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
A. Samii, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
C. P. Zabetian, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
V. Bonifati, MD, PhD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
C. Van Broeckhoven, PhD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
M. J. Farrer, PhD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
Z. K. Wszolek, MD
From the Departments of Neurology and Neuroscience (K.H., R.R., J.M.K., O.A.R., L.B., R.J.U., M.J.F., Z.K.W.), Mayo Clinic College of Medicine, Jacksonville, FL; Department of Neuroscience (K.H.), NTNU–Norwegian University of Science and Technology, Trondheim, Norway; Neurodegenerative Brain Diseases Group (R.R., K.N., J.T., C.V.B.), Department of Molecular Genetics, VIB, Laboratory of Neurogenetics (R.R., K.N., J.T., C.V.B.), Institute Born-Bunge, and University of Antwerp (R.R., K.N., J.T., C.V.B., P.P., P.C., P.P.D.D., S.E.), Antwerpen, Belgium; Department of Neurology (J.M.G.), Royal Victoria Hospital, Belfast, Ireland; Singapore General Hospital (E.-K.T.), Singapore; Parkinson's Disease and Movement Disorders Unit (C.G., E.T.), Institut Clínic de Neurociències, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Spain; Parkinson Institute (S.G.), Istituti Clinici di Perfezionamento, Milan, Italy; Neurology Division (M.G.), INRCA Institute, Ancona, Italy; Department of Neurology (G.R.), University of Insubria, Varese, Italy; Department of Neurology (U.W., R.B.), University of Rostock, Germany; Hertie Institute for Clinical Brain Research (D.B., T.G.), Tubingen, Germany; Division of Neurology (P.P., P.C.), University Hospital Antwerpen, Belgium; Laboratory of Neurobiology (P.P., P.C.) and Laboratory of Neurochemistry and Behavior (P.P.D.D., S.E.), Institute Born-Bunge, Antwerpen, Belgium.; Division of Neurology (P.P.D.D., S.E., B.P.), ZNA Middelheim Antwerp, Antwerpen, Belgium; Indiana University School of Medicine (T.F.), Indianapolis; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine (W.C.N.), OH; Department of Neurology and Human Genetics (J.H., C.K.), University of Lübeck, Germany; Department of Neurology (A.S., C.P.Z.), University of Washington School of Medicine, Seattle; Geriatric Research Education and Clinical Center (C.P.Z.), Veterans Affairs Puget Sound Health Care System, Seattle, WA; and Department of Clinical Genetics (V.B.), Erasmus MC, Rotterdam, The Netherlands.
Notes
Address correspondence and reprint requests to Dr. Zbigniew K. Wszolek, Department of Neurology, Mayo Clinic College of Medicine, Cannaday Bldg., 2E, 4500 San Pablo Road, Jacksonville, FL 32224
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