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March 17, 2008

Diffusion tensor imaging of acute mild traumatic brain injury in adolescents

E. A. Wilde, PhD, S. R. McCauley, PhD, J. V. Hunter, MD, E. D. Bigler, PhD, Z. Chu, PhD, Z. J. Wang, PhD, G. R. Hanten, PhD, M. Troyanskaya, MD, R. Yallampalli, BS, X. Li, MS, J. Chia, MS, and H. S. Levin, PhDAuthors Info & Affiliations

March 18, 2008 issue

70 (12) 948-955

https://doi.org/10.1212/01.wnl.0000305961.68029.54

Abstract

Background: Despite normal CT imaging and neurologic functioning, many individuals report postconcussion symptoms following mild traumatic brain injury (MTBI). This dissociation has been enigmatic for clinicians and investigators.

Methods: Diffusion tensor imaging tractography of the corpus callosum was performed in 10 adolescents (14 to 19 years of age) with MTBI 1 to 6 days postinjury with Glasgow Coma Scale score of 15 and negative CT, and 10 age- and gender-equivalent uninjured controls. Subjects were administered the Rivermead Post Concussion Symptoms Questionnaire and the Brief Symptom Inventory to assess self-reported cognitive, affective, and somatic symptoms.

Results: The MTBI group demonstrated increased fractional anisotropy and decreased apparent diffusion coefficient and radial diffusivity, and more intense postconcussion symptoms and emotional distress compared to the control group. Increased fractional anisotropy and decreased radial diffusivity were correlated with severity of postconcussion symptoms in the MTBI group, but not in the control group.

Conclusions: In adolescents with mild traumatic brain injury (MTBI) with Glasgow Coma Scale score of 15 and negative CT, diffusion tensor imaging (DTI) performed within 6 days postinjury showed increased fractional anisotropy and decreased diffusivity suggestive of cytotoxic edema. Advanced MRI-based DTI methods may enhance our understanding of the neuropathology of TBI, including MTBI. Additionally, DTI may prove more sensitive than conventional imaging methods in detecting subtle, but clinically meaningful, changes following MTBI and may be critical in refining MTBI diagnosis, prognosis, and management.

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Information & Authors

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Published In

Neurology^®

Volume 70 • Number 12 • March 18, 2008

Pages: 948-955

PubMed: 18347317

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© 2008.

Publication History

Published online: March 17, 2008

Published in print: March 18, 2008

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Affiliations & Disclosures

E. A. Wilde, PhD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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S. R. McCauley, PhD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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J. V. Hunter, MD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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E. D. Bigler, PhD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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Z. Chu, PhD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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Z. J. Wang, PhD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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G. R. Hanten, PhD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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M. Troyanskaya, MD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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R. Yallampalli, BS

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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X. Li, MS

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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J. Chia, MS

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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H. S. Levin, PhD

From the Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and the University of Texas–Houston Medical School (E.A.W., S.R.M., G.R.H., M.T., R.Y., X.L., H.S.L.); Department of Radiology (J.V.H., Z.C., Z.J.W.), Baylor College of Medicine, Houston, TX; E.B. Singleton Department of Diagnostic Imaging (J.V.H.), Texas Children's Hospital, Houston; Departments of Psychology (E.D.B.) and Neuroscience (E.D.B.), Brigham Young University, Provo, UT; Department of Psychiatry (E.D.B.) and the Utah Brain Institute (E.D.B.), University of Utah; and Philips Medical Systems (J.C.), Cleveland, OH.

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Notes

Address correspondence and reprint requests to Dr. Elisabeth A. Wilde, Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, 1709 Dryden Rd., Ste. 725, Houston, TX 77025 [email protected]

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