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Abstract

Objective

To report the association between type 1 Gaucher disease (GD1) and amyotrophic lateral sclerosis (ALS) in 3 unrelated families and to explore whether GBA variants influence the risk of ALS.

Methods

We conducted retrospective chart reviews of patients with GD1 or their family members diagnosed with ALS. To further investigate whether there is an association between ALS and GD, we performed exploratory analyses for the presence of GBA variants in 3 ALS cohorts from Toronto (Canada), Montreal (Canada), and Project MinE (international), totaling 4,653 patients with ALS and 1,832 controls.

Results

We describe 2 patients with GD1 and 1 obligate GBA mutation carrier (mother of GD1 patient) with ALS. We identified 0 and 8 GBA carriers in the Toronto and Montreal cohorts, respectively. The frequencies of GBA variants in patients with ALS in the Montreal and Project MinE cohorts were similar to those of Project MinE controls or Genome Aggregation Database population controls.

Conclusions

The occurrence of ALS in biallelic or monoallelic GBA mutation carriers described here, in addition to common pathogenic pathways shared by GD1 and ALS, suggests that GBA variants could influence ALS risk. However, analyses of GBA variants in ALS cohorts did not reveal a meaningful association. Examination of larger cohorts and neuropathologic studies will be required to elucidate whether patients with GD1 are indeed at increased risk for ALS.
Gaucher disease (GD) is a lysosomal storage disorder (LSD) caused by biallelic mutations in the GBA gene. GBA variants are also important risk factors for synucleinopathies, specifically Parkinson disease (PD) and dementia with Lewy bodies (DLB).1 Of interest, other LSD-related genes have been implicated in neurodegeneration. For instance, SMPD1 variants were recently associated with risk of PD.2 Although multiple pathways are involved in PD pathogenesis, the main mechanism thought to underlie the association between LSD and PD is dysfunction in the autophagy-lysosomal pathway (ALP).3
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that also likely results from several pathogenic mechanisms, including ALP dysfunction.4 Recent case reports of patients diagnosed with both ALS and a LSD, such as Fabry disease or type 3 GD,5,6 raise the possibility that common lysosomal abnormalities may underlie the co-occurrence of these disorders. The aims of this study are (1) to report the association between type 1 GD (GD1) and ALS in 3 unrelated families and (2) to explore whether GBA variants increase the risk of developing ALS.

Methods

Patients

Fifty-six patients with GD1 from the Mark Freedman & Judy Jacobs Program for Gaucher Disease at Mount Sinai Hospital (Toronto, Canada) underwent routine assessment by a neurologist (L.V.K.) between 2017 and 2020. One patient was diagnosed with ALS (case 1), and 1 patient had a first-degree relative with ALS (case 3). One GD1 patient with probable ALS (case 2) was identified at a medical center in Israel.

Genetic Analyses

We examined for GBA variants in 3 ALS cohorts: (1) 125 patients with ALS from Sunnybrook Health Sciences Centre (Toronto, Canada) who underwent whole-genome sequencing (WGS) at Genome Quebec (Montreal, Canada); (2) 162 French-Canadian patients with ALS who underwent whole-exome sequencing (WES) at the Montreal Neurological Institute (Montreal, Canada); and (3) 4,366 patients with ALS and 1,832 age- and sex-matched controls from the international Project MinE WGS data set.7,8 Only exons 1–9 were analyzed; exons 10 and 11 were not analyzed due to similarities to the pseudo-GBA gene and limitations regarding reliability of WGS or WES findings in these exons. Only nonsynonymous and loss-of-function GBA variants were analyzed. We used the legacy glucocerebrosidase protein sequence nomenclature to describe the variants. For details, see e-Methods (links.lww.com/NXG/A428).

Standard Protocol Approvals, Registrations, and Patient Consents

Informed consent was obtained from case 1 and next of kin of case 3. Relatives of case 2 were not contactable, and thus, the case description was anonymized. Retrospective review of clinical data was conducted in accordance with the Helsinki Declaration. Informed consent for participation in the genetic study was obtained from the Toronto participants in accordance with the University of Toronto research ethics board (protocol #34754) and from the French-Canadian Montreal participants in accordance with the Montreal Neurological Institute and Hospital research ethics board (approval #2017-2740), affiliated with the McGill University Health Centre research ethics board.

Data Availability

All data relevant from case 1, case 3, and Project MinE are included in the article or uploaded as supplementary information. Anonymized data from case 2 may be shared by request from any qualified investigator.

Results

Patients

Case 1 was diagnosed with clinically probable laboratory-supported ALS. Case 2 presented with probable ALS, but ultimately developed clinically definite ALS. Case 3 was an obligate GBA mutation carrier who was also diagnosed with ALS. She was the mother of a patient with GD1 with PD. Clinical data and genetic investigations are described in table 1, figure e-1 and e-Results (links.lww.com/NXG/A428).
Table 1 GBA Patients With ALS

ALS Cohorts

We did not identify any patients with ALS with a GBA variant by WGS in the Toronto cohort. Eight patients in the French-Canadian ALS cohort were found to have one of the following GBA variants: E326K, T369M, N370S, and S52L (table 2). In 2 cases, there was a variant of uncertain significance in an ALS-related gene: (1) CCNF H69Y variant in a GBA T369M carrier and (2) DCTN1 G467A variant in a GBA E326K carrier. The frequency of GBA variants in the French-Canadian ALS cohort was similar to that of European population controls in the Genome Aggregation Database (gnomAD) database. Thirty-five GBA variants were identified in patients with ALS or controls from the Project MinE data set and were rare (table 3). The frequency of these GBA variants in ALS patients was similar to that of Project MinE or gnomAD population controls.
Table 2 GBA Variants Identified in the Montreal French-Canadian ALS Cohort
Table 3 GBA Variants Identified in Patients With ALS or Controls From the Project MinE Data Set7,8
The allele frequency (AF) of N370S present in case 1, case 2, and the daughter of case 3 was 0.003 in the French-Canadian cohort (similar to the AF found in European gnomAD controls) and 0.002176 in ALS Project MinE patients (similar to the AF found in ALS Project MinE controls). W378G, c.84dupG, and P236T found in case 1, case 2, and the daughter of case 3, respectively, were not present in any of the ALS cohorts.

Discussion

Although the co-occurrence of GD1 with PD and the increased risk of PD among GBA mutation carriers are well established, the association of GD1 with ALS is rare.1 Of interest, 2 of 3 ALS cases reported here (1 patient with GD1 and 1 obligate GBA mutation carrier) have a family history of PD. Neurodegeneration in PD and ALS results from several shared mechanisms, including lysosomal dysfunction.3,4 Furthermore, a complex overlap between parkinsonian and motor neuron syndromes has long been appreciated with parkinsonism and ALS co-occurring within families or even within an individual patient. A genetic basis may underlie some cases of parkinsonism and ALS overlap, most notably nucleotide repeats in C9orf72 or ATXN2.9,10 Rare cases with both parkinsonism and ALS have been reported with mutations in DJ-1,11 TARDBP,12 or ANG.13
One of the patients with ALS reported here (case 1) had GD1 due to W378G and N370S GBA mutations. N370S is one of the most frequent GBA mutations reported to be associated with increased PD risk.1 W378G is a French-Canadian founder GBA mutation more recently linked to GD1 and synucleinopathies when found in compound heterozygosity with N370S.14 Although case 1 did not have PD, there was a family history of PD and reported DLB (figure e-1, links.lww.com/NXG/A428). He was found to have a variant of uncertain significance in SQSTM1, but it did not segregate with the various neurodegenerative diseases in his family and therefore was not considered pathogenic. The increased risk of synucleinopathies with W378G and N370S raises the possibility of a synucleinopathy mimicking ALS in case 1 and possibly case 3. Lewy pathology can accompany typical MND pathology in patients with co-occurrence of ALS and parkinsonism15 and sometimes in patients with ALS without clinical parkinsonism.16 However, we did not find any definitive reports in the literature of Lewy pathology occurring in isolation (i.e., in the absence of MND pathology in both the brain and spinal cord) in patients presenting clinically with only ALS, without parkinsonian features. Yet, we cannot fully eliminate this possibility because we have no autopsy data for our patients.
Limitations of our study include the lack of neuropathologic data and lack of genetic data for ALS-related genes in 2 cases. In addition, genetic analyses only included exons 1–9 of the GBA gene and thus potentially excluded some GBA variants. This likely had a minimal effect on our results because mutations in the excluded exons in Europeans are rare.17 Identification of complex alleles was also limited with our genotyping methods.
Our analyses of GBA variants among 4,653 patients with ALS and 1,832 controls did not support heterozygosity for a GBA variant (i.e., 1 mutant GBA allele) as a risk factor for ALS. In contrast, a strong association between GBA variants and PD was previously demonstrated in a study of 5,691 patients with PD and 4,898 controls.18 Co-occurrence of GD1 (i.e., 2 mutant GBA alleles) and ALS in our reported cases could be coincidental; however, a previous report of ALS in a patient with type 3 GD 6 and the existence of common pathogenic pathways shared by GD and ALS suggest that GD could influence ALS risk. The association between GD1 and PD began with a suggestion from case reports, but definitive proof was obtained from a study of over 400 patients with GD.19 Considering that ALS is approximately one hundred times less prevalent than PD, we expect that examination of much larger numbers of GD patients will be required to elucidate whether indeed there is a link between ALS and GD.

Glossary

AF
allele frequency
ALP
autophagy-lysosomal pathway
ALS
amyotrophic lateral sclerosis
DLB
dementia with Lewy bodies
GD
Gaucher disease
GD1
type 1 GD
gnomAD
Genome Aggregation Database
LSD
lysosomal storage disorder
MND
motor neuron disease
PD
Parkinson disease
WES
whole-exome sequencing
WGS
whole-genome sequencing

Acknowledgment

The authors thank the patients, the participants in each of the cohorts, the Project MinE GWAS Consortium, and the families for their involvement.

Appendix Authors

References

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Information & Authors

Information

Published In

Neurology® Genetics
Volume 7Number 4August 2021

Publication History

Received: February 20, 2021
Accepted: April 23, 2021
Published online: May 18, 2021
Published in print: August 2021

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Disclosure

L.M. Oliveira received funding for travel from Medtronic. T. Rastin has no disclosures. G.A.M. Nimmo received honoraria from Pfizer and Shire/Takeda and received consulting fees from Shire/Takeda. J.P. Ross received a doctoral student fellowship from the ALS Society of Canada and currently receives a Canadian Institutes of Health Research Frederick Banting & Charles Best Canada Graduate Scholarship (FRN 159279). P.A. Dion received funding from the International Essential Tremor Foundation and currently receives funding from ALS Canada, Brain Canada, and Radala Foundation. M. Zhang, D.-L. Nevay, D. Arkadir, and M. Gotkine have no disclosures. C. Barnett has been a consultant for Akcea, Takeda, and Alexion and received research grants from Octapharma and Grifols. C.L. Shoesmith serves as scientific advisory board member for Mitsubishi Tanabe Pharma Canada, serves as DSMB member for Orion, and serves as site principal investigator for clinical trials run by Biogen and AL-S Pharma. A. Zimran receives honoraria from Pfizer, Takeda, and BioEvents, receives consulting fees from Takeda, Prevail Therapeutics, Avrobio, and Insightec, and receives research grants from Sanofi/Genzyme, Takeda, Pfizer, and Centogene. E.A. Rogaeva, L. Zinman, and G.A. Rouleau have no disclosures. Z. Gan-Or received consulting fees from Denali, Genzyme (now Sanofi), Inception Sciences (now Ventus), Idorsia, Lysosomal Therapeutics Inc., Prevail Therapeutics, Deerfield, Neuron23, and Handl Therapeutics. D. Amato received honoraria, served on advisory board, and received funding for travel from Actelion, Pfizer, Sanofi/Genzyme, and Shire/Takeda. L.V. Kalia served as site principal investigator for clinical trials run by ApoPharma, received educational grants from Allergan, and received honoraria from the NIH, Pfizer, and Shire/Takeda. Go to Neurology.org/NG for full disclosures.

Study Funding

L.V. Kalia received support from Canadian Institutes of Health Research (CIHR) Clinician Scientist Award (MC2-157081). P.A. Dion received support from ALS Canada-Brain Canada Hudson Translational team grant and Radala Foundation. E.A. Rogaeva received support from ALS Canada. M. Zhang received support from Shanghai Pujiang Program (19PJ1410300) and Fundamental Research Funds for the Central Universities. Z. Gan-Or received support from Fonds de recherche du Québec—Santé (FRQS) Chercheurs-Boursiers Award, Parkinson Quebec, and Parkinson Canada Young Investigator Award.

Authors

Affiliations & Disclosures

From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1) Medtronic: funding for travel to speak at conference
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1.
NONE
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1.
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1.
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1.
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1.
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1.
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1.
NONE
Research Support, Academic Entities:
1.
(1) Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network.
Research Support, Foundations and Societies:
1.
(1) Susan and Poul Hansen Movement Disorders Fellowship Fund
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Tara Rastin, MD* [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
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Graeme A.M. Nimmo, MBBS, MSc [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
(1) Shire/Takeda advisory board
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1) Shire/Takeda, travel and speaker honoraria
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
(1) Shire/Takeda
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
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1.
NONE
Legal Proceedings:
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Jay P. Ross, BSc [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
(1) Canadian Institutes of Health Research (CIHR), FRN 159279, Doctoral Student, 2018-2021.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
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NONE
Patrick A. Dion, PhD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Ming Zhang, PhD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Dayna-Lynn Nevay, MSc, CCGC [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
David Arkadir, MD, PhD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Marc Gotkine, MBBS [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
1) Joint PCT of AI tool for predictive modelling of ALS progression
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
1) Israeli Ministry of Science and Technology, 3-13324, PI, ( 2017-2019)
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
1) IsrALS
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Carolina Barnett, MD, PhD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
(1) Alexion: Advisory board
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
(1) Consultant CSL (2) Consultant Akcea
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
(1) Grant suport, Grifols (2) Grant support, Octapharma
Research Support, Government Entities:
1.
(1) Grant support, Department of Defense (2) Grant support, NIH
Research Support, Academic Entities:
1.
(1) Grant support, MG Net
Research Support, Foundations and Societies:
1.
(1) Grant Support, Muscular Dystrophy Canada
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
(1) Primary developer of the Myasthenia Gravis Imapirment Index, may receive royalties.
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Christen L. Shoesmith, MD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
1) Serving on a data safety monitoring board for Orion pharmaceuticals. 2) Serving on a scientific advisory board for Mitsubishi Tanabe Pharma Canada.
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
1. Speaker fee funded by Mitsubishi Tanabe Pharma Canada
Other Activities:
1.
Husband is employed by Roche Canada.
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Site principal investigator for clinical trial for Cytokinetics Site principal investigator for clinical trial for Orphazyme Site principal investigator for clinical trial for Biogen
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Ari Zimran, MD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Received travel fees and honoraria from Genzyme/Sanofi, Pfizer and Shire for participation at educational/promotional meetings and advisory forums
Editorial Boards:
1.
Member of editorial board of Blood Cells, Molecules and Diseases (BCMD)and International Journal of Molecular Sceinces (IJMS)
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Consultant to Prevail Therapeutics, AVROBIO and Takeda (all commercial entities)
Speakers' Bureaus:
1.
Pfizer, Genzyme/Sanofi, Takeda and BioEvents
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
Had stock options in Protalix BioTherapeutics - a commercial entity (ended 2014)
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Ekaterina A. Rogaeva, PhD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
(1) the Canadian Consortium on Neurodegeneration in Aging
Research Support, Foundations and Societies:
1.
(1) the ALS Canada-Brain Canada Hudson Grant (2) the Canadian Consortium on Neurodegeneration in Aging
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Lorne Zinman, MD, MSc [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
1)DSMB Chair, NIH sponsored Study (non profit entity). 2)Advisory board - Biogen Idec (commercial) 3)Advisory board - MTPA (commercial)
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
1) Mitsubishi Tanabe Pharma, consulting honorarium 2) Biogen, consulting honorarium 3) Cytokinetics, study steering committee
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Guy A. Rouleau, MD, PhD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
(1) CIHR Foundation Scheme (FDN-143260); 07/2015 to 06/2022; 708,381$/year. Genetic & Biological Studies of Brain Disorders. Role: Principal Applicant (2) ALS Society of Canada, 09/2013 to 08/2015. Assessment of somatic mutations and repeat instability in known ALS genes. Role: Principal Applicant. (3) ALS Association (OJ3X54), 08/2012 to 07/2015. Characterization of C9ORF72 expansion stability in ALS/FTD patients. Role: Principal Applicant.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Name: Canadian Institute of Health Research - Foundation Scheme (Principal Applicant) Address: Ottawa, Canada Type of support: Research grant Name: Genome Quebec (Co-Applicant) Address: Montreal, Canada Type of support: Research grant Name: ALS-Brain Canada (Principal Applicant) Address: Toronto, Canada Type of support: Research grant Name: ALS-Brain Canada (Co-Applicant) Address: Toronto, Canada Type of support: Research grant Name: Brain Canada (Co-Applicant) Address: Toronto, Canada Type of support: Research grant Name: Canadian Institute of Health Research - CCNA (Co-Applicant) Address: Ottawa, Canada Type of support: Research grant
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Ziv Gan-Or, MD, PhD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
(1) Bial Biotech Inc. (2) Handl Therapeutics
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1)Lysosomal Therapeutics Inc., travel and speaker honoraria, (2) Idorsia, travel and speaker honoraria, (3) Denali, travel and speaker honoraria.
Editorial Boards:
1.
(1) Parkinsonism and Related Disorders, editorial board, 2018- current (2) Journal of Parkinson's Disease, associated editor, 2019-current
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
(1) Lysosomal Therapeutics Inc., (2) Denali, (3) Prevail Therapeutics, (4) Idorsia, (5) Inception Sciences, (6) Deerfield, (7) Ono Therapeutics, (8) Neuron23, (9) Handl Therapeutics, (10) Lighthouse, (11) Guidepoint, (12) Bial Biotech Inc.
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Dominick Amato, MD [email protected]
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
(1)Sanofi/Genzyme (2)Takeda/Shire
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1) Takeda: honorarium for preparation and presentation of webinar (Pathfinder and Fast-Tracking the Diagnosis of Gaucher Disease) (2) Janssen: travel support
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Lorraine V. Kalia, MD, PhD
From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General Hospital, University Health Network, University of Toronto, Ontario; Department of Human Genetics (J.P.R., P.A.D., G.A.R., Z.G.-O.), Montreal Neurological Institute and Hospital (J.P.R., P.A.D., G.A.R., Z.G.-O.), and Department of Neurology and Neurosurgery (P.A.D., G.A.R., Z.G.-O.), McGill University, Quebec; Tanz Centre for Research in Neurodegenerative Diseases (M.Z., E.A.R., L.V.K.), University of Toronto, Ontario, Canada; Shanghai First Rehabilitation Hospital (M.Z.), School of Medicine, Clinical Center for Brain and Spinal Cord Research (M.Z.), and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; Department of Neurology (D. Arkadir, M.G.), Hadassah Medical Center, Hebrew University, Jerusalem, Israel; Ellen and Martin Prosserman Centre for Neuromuscular Diseases (C.B.), Division of Neurology, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto; London Health Sciences Centre (C.L.S.), London, Ontario, Canada; Gaucher Unit (A.Z.), Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel; Division of Neurology (L.Z.), Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (L.V.K.), Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada.
Disclosure
Scientific Advisory Boards:
1.
(1) NINDS Parkinson's Disease Biospecimen Review Access Committee (PD BRAC)
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1) International Society for Neurochemistry, funding for travel to speak at conference (2) National Gaucher Foundation of Canada, honorarium to speak at conference (3) Takeda, honorarium to speak at conference (4) University of Ottawa, honorarium to speak at conference
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
(1) ApoPharma Inc (2) UCB Biopharma SRL
Research Support, Government Entities:
1.
(1) Canadian Institutes of Health Research, Principal Investigator, 2015-2023 (2) Natural Sciences and Engineering Research Council of Canada, Principal Investigator, 2015-2022 (3) Ontario Brain Institute, Principal Investigator, 2018-2021
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
(1) Michael J. Fox Foundation for Parkinson’s Research (2) Parkinson Canada (3) Toronto General & Western Hospital Foundation
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Correspondence Dr. Kalia [email protected]
Go to Neurology.org/NG for full disclosures. Funding information is provided at the end of the article.
*
These authors contributed equally to this work (i.e., they are co–first authors).
The Article Processing Charge was funded by the CIHR.

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  1. Rapid-Onset Dystonia and Parkinsonism in a Patient With Gaucher Disease, Journal of Movement Disorders, 16, 3, (321-324), (2023).https://doi.org/10.14802/jmd.23074
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  2. Genetic Testing in Clinical Movement Disorders: A Case-Based Review, Seminars in Neurology, 43, 01, (147-155), (2023).https://doi.org/10.1055/s-0043-1763507
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  3. Frequency of Parkinson’s Disease Genes and Role of PARK2 in Amyotrophic Lateral Sclerosis: An NGS Study, Genes, 13, 8, (1306), (2022).https://doi.org/10.3390/genes13081306
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