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July 2, 2014

Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting

Ergun Y. Uc, MD, Kevin C. Doerschug, MD, Vincent Magnotta, PhD, Jeffrey D. Dawson, ScD, Teri R. Thomsen, MD, Joel N. Kline, MD, Matthew Rizzo, MD, … Show All … , Sara R. Newman, BS/BA, Sonya Mehta, MS, Thomas J. Grabowski, MD, Joel Bruss, BA, Derek R. Blanchette, MS, Steven W. Anderson, PhD, Michelle W. Voss, PhD, Arthur F. Kramer, PhD, and Warren G. Darling, PhDAuthors Info & Affiliations
July 29, 2014 issue
83 (5) 413-425
https://doi.org/10.1212/WNL.0000000000000644
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Abstract

Objectives:

To (1) investigate effects of aerobic walking on motor function, cognition, and quality of life in Parkinson disease (PD), and (2) compare safety, tolerability, and fitness benefits of different forms of exercise intervention: continuous/moderate intensity vs interval/alternating between low and vigorous intensity, and individual/neighborhood vs group/facility setting.

Methods:

Initial design was a 6-month, 2 × 2 randomized trial of different exercise regimens in independently ambulatory patients with PD. All arms were required to exercise 3 times per week, 45 minutes per session.

Results:

Randomization to group/facility setting was not feasible because of logistical factors. Over the first 2 years, we randomized 43 participants to continuous or interval training. Because preliminary analyses suggested higher musculoskeletal adverse events in the interval group and lack of difference between training methods in improving fitness, the next 17 participants were allocated only to continuous training. Eighty-one percent of 60 participants completed the study with a mean attendance of 83.3% (95% confidence interval: 77.5%–89.0%), exercising at 46.8% (44.0%–49.7%) of their heart rate reserve. There were no serious adverse events. Across all completers, we observed improvements in maximum oxygen consumption, gait speed, Unified Parkinson's Disease Rating Scale sections I and III scores (particularly axial functions and rigidity), fatigue, depression, quality of life (e.g., psychological outlook), and flanker task scores (p < 0.05 to p < 0.001). Increase in maximum oxygen consumption correlated with improvements on the flanker task and quality of life (p < 0.05).

Conclusions:

Our preliminary study suggests that aerobic walking in a community setting is safe, well tolerated, and improves aerobic fitness, motor function, fatigue, mood, executive control, and quality of life in mild to moderate PD.

Classification of evidence:

This study provides Class IV evidence that in patients with PD, an aerobic exercise program improves aerobic fitness, motor function, fatigue, mood, and cognition.

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Supplementary Material

File (appendix_e-1.pdf)
File (figure_e-1.pdf)
File (table_e-1.pdf)

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Information & Authors

Information

Published In

Neurology®
Volume 83 • Number 5 • July 29, 2014
Pages: 413-425
PubMed: 24991037

Copyright

© 2014 American Academy of Neurology.

Publication History

Received: December 8, 2013
Accepted: April 27, 2014
Published online: July 2, 2014
Published in print: July 29, 2014

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Disclosure

The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

Study Funding

Supported primarily by the Department of Veterans Affairs, Rehabilitation R&D Branch Merit Review Award B6261R (E.Y.U.), and also by National Center for Research Resources grant UL1RR024979 and National Institute of Environmental Health Sciences grant ES005605 (University of Iowa), donations from Charles W. and Harriet J. Seedorff Family (E.Y.U.), R01 AG017177 (M.R.), and R01 NS044930 (E.Y.U.). The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the granting agencies.

Authors

Affiliations & Disclosures

Ergun Y. Uc, MD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
1-The Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development (B6261R, Merit Review Award, PI, 2009-2012; I01 RX000 170-01, Merit Review Award, PI, 2010-12). 2-NINDS (R01 NS044930, PI, 2003-2010). The content of this manuscript is solely the responsibility of the authors and do not necessarily represent the official views of the granting agencies.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Donations from Charles W. and Harriet J. Seedorff Family to EYU between 2007-2011 for research support.
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Kevin C. Doerschug, MD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
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Vincent Magnotta, PhD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
I have received salary support as a co-investigator from a Merit Review Award from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development (B6261R, PI: EYU, 2009-2012)
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
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Jeffrey D. Dawson, ScD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
(1) NIH, DSBM's for a clinical trial, 2003-2014.
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1) American Statistical Association, funding to attend meetings in 2013 and 2014 as part of duties of Council on Chapters Governing Board.
Editorial Boards:
1.
Neurosurgery, reviewer, 2012-2014
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Unpaid statistical consultant, Healing Hands for Haiti International
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH, Investigator, HL091917, 2010-2015 NIH, Investigator, HL116311, 2013-2018 NIH, Investigator, AG017177, 2003-2018 NIH, Investigator, HL082711, 2007-2013 NIH, Investigator, AR054439, 2009-2013 NIH, Biostatistician, HD062507, 2010-2015 NIH, Investigator/mentor, T15-HL097622, 2009-2016 AHRQ, Biostatistician, HS019966, 2012-2013 Toyota Motor Corp, Biostatistician, 2013-2015 USDVA, Investigator, B6261R, 2009-2012
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Teri R. Thomsen, MD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Joel N. Kline, MD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
i have been PI or co-investigator on industry-sponsored studies related to asthma and COPD that have been sponsored by 1)Boston Scientific, 2)Novartis, 3)GSK, 4) Teva, 5)Amgen, 6)Genentech
Research Support, Government Entities:
1.
NIH: CTSA:UL1 TR000442
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Matthew Rizzo, MD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Sara R. Newman, BS/BA
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
I have been an employee of VA Medical Center of Iowa City in the role of study coordinator and research assistant. My position was supported by grants from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development (B6261R, Merit Review Award, PI: EYU, 2009-2012; I01 RX000 170-01, Merit Review Award, PI: EYU, 2010-12)
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
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Sonya Mehta, MS
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
For Sonya Mehta USDVA, Co-Investigator, B6261R, 2009-2012 NIH 1R01DK089036, Research Scientist, 2011-2014 NIH RC4 NS073008-01, Research Scientist, 2011-2013 NIH R01 NS 058658-01A2, Research Scientist, 2011-2014 For Gene Hess (husband of Sonya Mehta) NIH 5 PL1 HL092557-5, Flow Core Manager, 07/01/11 � 6/30/13
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Thomas J. Grabowski, MD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
Frontiers in Brain Imaging Methods, Associate Editor, 2013- present
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH NINDS, R01 NS058658, Principal Investigator, 2008-2014 NSF 1333841, Co-Investigator, 2013-2014 NIH NINDS RC4 NS073008, Principal Investigator, 2010-2013
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Joel Bruss, BA
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
I have received salary support as a research assistant from a Merit Review Award from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development (B6261R, PI: EYU, 2009-2012).
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Derek R. Blanchette, MS
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Steven W. Anderson, PhD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
(1)NIH, AG017177-09A1, Co-investigator, 2013 � 2018 (2)NIH HL091917, Co-investogator, 2010 � 2015
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Michelle W. Voss, PhD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Arthur F. Kramer, PhD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
all editorial board members (current year) Human Factors, Psychology & Aging, Acta Psychologia
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
research support from Abbott
Research Support, Government Entities:
1.
R37 AG025667B (PI-Kramer) 7/15/2010-06/30/2016 .50 Calendar NIH $196,134 Influence of Fitness and Cognitive Training on Brain and Cognition This project examines the effects of fitness and cognitive training on human cognition, brain structure, and brain function of older adults. R01 AG036682A (PI-Kramer) 3/01/2011-02/28/2015 .60 Calendar NIH $277,635 Acting Out: Influence of an Acting Intervention on Cognition and Brain Function This project examines the influence of acting training on cognition and brain function. Navy Subaward through KSU (Kramer) 8/01/2011-07/31/2014 .48 Calendar Office of Naval Research $129,847 A New Measure of the Useful Field of View (UFOV): The Gaze- contingent Peripheral Blur Detection Task This project examines the utility of a gaze contingent eye tracking technique for the tracking of visual attention in dynamic environments. CNLM ANGC 2012-01589 (PI-Cohen) 9/21/2011-12/31/2016 .24 Calendar Abbott Laboratories $370,795 Grand Challenge - Website Development and Admin Core
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Warren G. Darling, PhD
From the Departments of Neurology (E.Y.U., T.R.T., M.R., S.R.N., J.B., S.W.A.), Internal Medicine (K.C.D., J.N.K.), Radiology (V.M.), Biostatistics (J.D.D., D.R.B.), Psychology (M.W.V.), and Health and Human Physiology (W.G.D.), University of Iowa, Iowa City; Neurology Service (E.Y.U., T.R.T., S.R.N.), Veterans Affairs Medical Center, Iowa City, IA; Department of Neurology (S.M., T.J.G.), University of Washington, Seattle; and Department of Psychology (A.F.K.), Beckman Institute, University of Illinois, Urbana-Champaign.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
U.S. Dept. of Veterans Affairs Merit Review Award B6261R (2009-2012), co-investigator U.S. National Institutes of Health R01: NS46367 (2010- 2014), co-investigator and subcontract PI U.S. National Institutes of Health R21: NS067189 (2010- 2012), co-investigator
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
MS Foundation of Canada (2010-2014) co-Investigator (donated effort, funding for graduate student)
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author

Notes

Correspondence to Dr. Uc: [email protected]
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

Author Contributions

Ergun Y. Uc: design or conceptualization of the study, analysis or interpretation of the data, drafting or revising the manuscript for intellectual content. Kevin C. Doerschug: analysis or interpretation of the data, drafting or revising the manuscript for intellectual content. Vincent Magnotta: drafting or revising the manuscript for intellectual content. Jeffrey D. Dawson: design or conceptualization of the study, analysis or interpretation of the data, drafting or revising the manuscript for intellectual content. Teri R. Thomsen: drafting or revising the manuscript for intellectual content. Joel N. Kline: analysis or interpretation of the data, drafting or revising the manuscript for intellectual content. Matthew Rizzo, Sara R. Newman, Sonya Mehta, Thomas J. Grabowski, and Joel Bruss: drafting or revising the manuscript for intellectual content. Derek R. Blanchette: analysis or interpretation of the data, drafting or revising the manuscript for intellectual content. Steven W. Anderson and Michelle W. Voss: drafting or revising the manuscript for intellectual content. Arthur F. Kramer and Warren G. Darling: design or conceptualization of the study, analysis or interpretation of the data, drafting or revising the manuscript for intellectual content.

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