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August 28, 2015

Hemorrhagic stroke following use of the synthetic marijuana “spice”

David Z. Rose, MD, Waldo R. Guerrero, MD, Maxim V. Mokin, MD, PhD, Clifton L. Gooch, MD, Andrea C. Bozeman, ARNP, Julia M. Pearson, PhD, and W. Scott Burgin, MDAuthors Info & Affiliations
September 29, 2015 issue
85 (13) 1177-1179
https://doi.org/10.1212/WNL.0000000000001973
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Abstract

The association between the street drug spice (K-2 or herbal incense), a synthetic marijuana, and intracranial hemorrhage (ICH) has not yet been described, but it has with acute ischemic stroke (AIS),1 seizure, and myocardial infarction.2 Two young patients (31 and 25 years old) independently presented to our hospital with subarachnoid hemorrhage (SAH) after spice inhalation. The first also had 2 large intraparenchymal hemorrhages (IPH); the other also had AIS. Both were previously healthy without hypertension, coagulopathy, bleeding diathesis, thrombocytopenia, intracranial aneurysm, arteriovenous malformation, connective tissue disease, or anticoagulant/antiplatelet medication use.

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Supplementary Material

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References

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Information & Authors

Information

Published In

Neurology®
Volume 85 • Number 13 • September 29, 2015
Pages: 1177-1179
PubMed: 26320200

Copyright

© 2015 American Academy of Neurology.

Publication History

Received: February 9, 2015
Accepted: May 11, 2015
Published online: August 28, 2015
Published in print: September 29, 2015

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Funding Information

Study funding: No targeted funding reported.Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

Authors

Affiliations & Disclosures

David Z. Rose, MD
From Morsani College of Medicine (D.Z.R., W.R.G., M.V.M., C.L.G., A.C.B., W.S.B.), University of South Florida; and Hillsborough County Medical Examiner's Office (J.M.P.), Tampa, FL.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
Asked to join editorial board for the Neurohospitalist journal (2013), unpaid
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
Speakers bureau for unbranded webcasts of ischemic stroke and atrial fibrillation for boehringer ingelheim; previously was on speakers bureau for Chiesi USA
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
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Waldo R. Guerrero, MD
From Morsani College of Medicine (D.Z.R., W.R.G., M.V.M., C.L.G., A.C.B., W.S.B.), University of South Florida; and Hillsborough County Medical Examiner's Office (J.M.P.), Tampa, FL.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Maxim V. Mokin, MD, PhD
From Morsani College of Medicine (D.Z.R., W.R.G., M.V.M., C.L.G., A.C.B., W.S.B.), University of South Florida; and Hillsborough County Medical Examiner's Office (J.M.P.), Tampa, FL.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
toshiba educational grant
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Clifton L. Gooch, MD
From Morsani College of Medicine (D.Z.R., W.R.G., M.V.M., C.L.G., A.C.B., W.S.B.), University of South Florida; and Hillsborough County Medical Examiner's Office (J.M.P.), Tampa, FL.
Disclosure
Scientific Advisory Boards:
1.
1. NeuralStem (DSMB Committee Member)
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
1. Neurology (Editorial Board Member, 2006 to present) 2. Journal of Clinical Neuromuscular Disease (Editorial Board Member, 2004 to present)
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
1. NeuralStem (Consultant for Neuro-regenerative Research) 2. CSL Behring (Consultant for Neuroimmunological disease therapeutic research) 3. Baxter Pharma (Consultant for Neuroimmunological disease therapeutic research) 4. Saneron (Consultant for Stem Cell/Neuroregeneration)
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Friedreich's Ataxia Research Alliance
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
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Andrea C. Bozeman, ARNP
From Morsani College of Medicine (D.Z.R., W.R.G., M.V.M., C.L.G., A.C.B., W.S.B.), University of South Florida; and Hillsborough County Medical Examiner's Office (J.M.P.), Tampa, FL.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Julia M. Pearson, PhD
From Morsani College of Medicine (D.Z.R., W.R.G., M.V.M., C.L.G., A.C.B., W.S.B.), University of South Florida; and Hillsborough County Medical Examiner's Office (J.M.P.), Tampa, FL.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
expert witness for plaintiff and defense cases in civil and criminal cases resulting from cases worked in our medical examiner office
View all articles by this author
W. Scott Burgin, MD
From Morsani College of Medicine (D.Z.R., W.R.G., M.V.M., C.L.G., A.C.B., W.S.B.), University of South Florida; and Hillsborough County Medical Examiner's Office (J.M.P.), Tampa, FL.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
Employee of the University of South Florida since 2011
Consultancies:
1.
Air Liquide Sante Internationale
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Cerevast Acorda Astra Zeneca Boehringer Ingelheim Pfizer Tampa General Hospital
Research Support, Government Entities:
1.
NIH N000936921 Sub Investigator 2011 to present
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
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Notes

Correspondence to Dr. Rose: [email protected]

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