C-reactive protein and efficacy of antiplatelet therapy in (intracranial) atherosclerosis
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C-reactive protein (CRP) and other inflammatory biomarkers can indicate both the severity and extent of atherosclerosis, reflecting the inflammatory nature of the disease process.1 Atherogenesis begins with an inflammatory response to vascular injury with cells and mediators initiating the healing response and later inducing growth of atherosclerotic plaques. Inflammation then increases plaque instability, promoting rupture, fissuring, or erosion—the pathogenetic milieu of thrombosis in atherothrombotic ischemic strokes.
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References
1.
Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999;340:115–126.
2.
Ridker PM, Danielson E, Fonseca FAH, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008;359:2195–2207.
3.
Feng D, Tracy RP, Lipinska I, Murillo J, McKenna C, Tofler GH. Effect of short-term aspirin use on C-reactive protein. J Thromb Thrombolysis 2000;9:37–41.
4.
Li J, Wang A, Zhao X, et al. High-sensitive C-reactive protein and dual antiplatelet in intracranial arterial stenosis. Neurology 2018;90:e447–e454.
5.
Schrör K. Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin Thromb Hemost 1997;23:349–356.
6.
Wijeyeratne YD, Heptinstall S. Anti-platelet therapy: ADP receptor antagonists. Br J Clin Pharmacol 2011;72:647–657.
7.
Ryu WS, Park SS, Kim YS, et al. Long-term natural history of intracranial arterial stenosis: an MRA follow-up study. Cerebrovasc Dis 2014;38:290–296.
8.
Kim BS, Chung PW, Park KY, et al. Burden of intracranial atherosclerosis is associated with long-term vascular outcome in patients with ischemic stroke. Stroke 2017;48:2819–2826.
9.
Eltoft A, Arntzen KA, Hansen JB, Wilsgaard T, Mathiesen EB, Johnsen SH. C-reactive protein in atherosclerosis: a risk marker but not a causal factor? A 13-year population-based longitudinal study: the Tromsø study. Atherosclerosis 2017;263:293–300.
10.
Mani V, Woodward M, Samber D, et al. Predictors of change in carotid atherosclerotic plaque inflammation and weight as measured by 18-FDG-PET and MRI, respectively, in the dal-PLAQUE study. Int J Cardiovasc Imaging 2014;30:571–582.
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© 2018 American Academy of Neurology.
Publication History
Published online: January 12, 2018
Published in print: February 6, 2018
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The authors report no disclosures. Go to Neurology.org/N for full disclosures.
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Cited By
- Rosuvastatin inhibit ox-LDL-induced platelet activation by the p38/MAPK pathway, Clinical Hemorheology and Microcirculation, (1-10), (2024).https://doi.org/10.3233/CH-242359
- Ticagrelor Versus Clopidogrel in Minor Stroke or Transient Ischemic Attack With Intracranial Artery Stenosis: A Post Hoc Analysis of CHANCE‐2, Journal of the American Heart Association, 12, 21, (2023).https://doi.org/10.1161/JAHA.123.031611
- Efficacy and Safety of Ticagrelor Versus Clopidogrel in Acute Minor Stroke or Transient Ischaemic Attack Patients with Different Intracranial Artery Stenosis Statuses: A Subgroup Analysis of CHANCE-2, A Randomized, Double-Blind, Controlled Trial, SSRN Electronic Journal, (undefined).https://doi.org/10.2139/ssrn.4054464
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