Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women
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I thank Dr. Sajedi for the comment on our article, [1] and for noting the interesting articles by Sajedi et al. [2-5] My colleagues and I have no explanation for the apparent drop in incidence of MS in Denmark in the 1960-1969 period, but we decided not to discuss any hypotheses which could not be tested by our data (or elsewhere). Countless factors confound the association between time or geography and MS. The way from covariation to causality is long, and a possible biological link between geomagnetic factors and MS remains inexplicable.
For disclosures, please contact the editorial office at [email protected].
The valuable article by Koch-Henriksen et al. depicted the alteration of multiple sclerosis (MS) incidence in the past six decades in Denmark. [1] As the authors stated, their nationwide MS registry showed a notable increase in MS incidence, but they neither discussed nor indicated to the importance of the decreasing trend of MS incidence in Denmark from 1950 to 1964, a fact that is obvious in figure 6. [1] Considering that period, the whole picture of MS incidence seems to be parabolic. Such a wax-and-wane pattern and its turning point are highly valuable for differentiating the potential environmental risk factors, based on their capability to explain it. There is not any evidence that the Danish diet or their food vitamin-D content changed dramatically during that period. Moreover, based on our recent study, the received solar ultra-violet B in Denmark cannot explain this incidence pattern. [2]
Valuable data should not be neglected in favor of current hypotheses. There are other potential environmental risk factors, like geomagnetic disturbances, that may show their capabilities to explain such incidence patterns when researchers consider the data as a whole. [3-5]
For disclosures, please contact the editorial office at [email protected].