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July 18, 2018

Hypoglossal nerve stimulation on sleep and level of alertness in OSA
A preliminary study

Pierre Philip, MD, PhD, Clemens Heiser, MD, PhD, Stéphanie Bioulac, MD, PhD, Ellemarije Altena, PhD, Guillame Penchet, MD, Emmanuel Cuny, MD, PhD, Benedikt Hofauer, MD, PhD, Pierre-Jean Monteyrol, PhD, and Jean-Arthur Micoulaud-Franchi, MD, PhDAuthors Info & Affiliations
August 14, 2018 issue
91 (7) e615-e619
https://doi.org/10.1212/WNL.0000000000006001
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Abstract

Objectives

To quantify the effect of hypoglossal nerve stimulation (HNS), a novel therapy for patients with obstructive sleep apnea, on objective level of alertness (measured with Maintenance of Wakefulness Test [MWT] values) and nocturnal sleep architecture.

Methods

Ten male patients (mean age 52.0 ± 9.4 years; mean body mass index 28.8 ± 3.3 kg/m2) noncompliant to continuous positive airway pressure received HNS (Inspire therapy) and were prospectively evaluated at baseline and 6 months after HNS therapy. Polysomnographic parameters (sleep breathing and sleep architecture) and objective level of alertness (MWT) were measured.

Results

The mean preimplantation apnea-hypopnea index of 46.7/h ± 12.2/h was reduced to 14.5/h ± 8.9/h at 6 months postimplantation (p < 0.001). The mean MWT latency improved from 25.0 ± 12.8 minutes at baseline to 36.8 ± 7.0 minutes after 6 months of treatment (p = 0.004). A reduction of N1% (11.8 ± 10.6 vs 4.2 ± 1.9, p = 0.04) was observed. The reduction in the duration of wake after sleep onset (WASO) was 71.4 ± 32.4 minutes vs 53.4 ± 13.5 minutes (p = 0.06) but was not significant. MWT latencies at 6 months were negatively correlated with the intensity of stimulation (r = −0.63, p = 0.05). Intensity of stimulation was positively correlated with WASO (r = 0.76, p = 0.01).

Conclusion

HNS improved the objective level of alertness and changed nocturnal sleep architecture. The level of neural stimulation determines the amount of nocturnal WASO and the level of objective level of alertness.

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References

1.
Strollo PJ Jr, Rogers RM. Obstructive sleep apnea. N Engl J Med 1996;334:99–104.
Crossref
PubMed
Google Scholar
2.
Philip P, Stoohs R, Guilleminault C. Sleep fragmentation in normals: a model for sleepiness associated with upper airway resistance syndrome. Sleep 1994;17:242–247.
PubMed
Google Scholar
3.
McArdle N, Douglas NJ. Effect of continuous positive airway pressure on sleep architecture in the sleep apnea-hypopnea syndrome: a randomized controlled trial. Am J Respir Crit Care Med 2001;164:1459–1463.
Crossref
PubMed
Google Scholar
4.
Tiihonen M, Partinen M. Polysomnography and Maintenance of Wakefulness Test as predictors of CPAP effectiveness in obstructive sleep apnea. Electroencephalogr Clin Neurophysiol 1998;107:383–386.
Crossref
PubMed
Google Scholar
5.
Kingshott RN, Vennelle M, Hoy CJ, Engleman HM, Deary IJ, Douglas NJ. Predictors of improvements in daytime function outcomes with CPAP therapy. Am J Respir Crit Care Med 2000;161:866–871.
Crossref
PubMed
Google Scholar
6.
Strollo PJ Jr, Soose RJ, Maurer JT, et al. Upper-airway stimulation for obstructive sleep apnea. N Engl J Med 2014;370:139–149.
Crossref
PubMed
Google Scholar
7.
Gillespie MB, Soose RJ, Woodson BT, et al. Upper airway stimulation for obstructive sleep apnea: patient-reported outcomes after 48 months of follow-up. Otolaryngol Head Neck Surg 2017;156:765–771.
Crossref
PubMed
Google Scholar
8.
Hofauer B, Philip P, Wirth M, Knopf A, Heiser C. Effects of upper-airway stimulation on sleep architecture in patients with obstructive sleep apnea. Sleep Breath 2017;21:901–908.
Crossref
PubMed
Google Scholar
9.
Eastwood PR, Barnes M, Walsh JH, et al. Treating obstructive sleep apnea with hypoglossal nerve stimulation. Sleep 2011;34:1479–1486.
Crossref
PubMed
Google Scholar
10.
Woodson BT, Gillespie MB, Soose RJ, et al. Randomized controlled withdrawal study of upper airway stimulation on OSA: short- and long-term effect. Otolaryngol Head Neck Surg 2014;151:880–887.
Crossref
PubMed
Google Scholar
11.
Van de Heyning PH, Badr MS, Baskin JZ, et al. Implanted upper airway stimulation device for obstructive sleep apnea. Laryngoscope 2012;122:1626–1633.
Crossref
PubMed
Google Scholar
12.
Heiser C, Thaler E, Boon M, Soose RJ, Woodson BT. Updates of operative techniques for upper airway stimulation. Laryngoscope 2016;126(suppl 7):S12–S16.
Crossref
PubMed
Google Scholar
13.
Vanderveken OM, Beyers J, Op de Beeck S, et al. Development of a clinical pathway and technical aspects of upper airway stimulation therapy for obstructive sleep apnea. Front Neurosci 2017;11:523.
Crossref
PubMed
Google Scholar

Information & Authors

Information

Published In

Neurology®
Volume 91 • Number 7 • August 14, 2018
Pages: e615-e619
PubMed: 30021916

Copyright

© 2018 American Academy of Neurology.

Publication History

Received: January 11, 2018
Accepted: May 14, 2018
Published online: July 18, 2018
Published in issue: August 14, 2018

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Disclosure

P. Philip is a consultant for UCB, Inspire, VitalAire, Nyxoah, and Vanda Medical. C. Heiser, S. Bioulac, E. Altena, G. Penchet, E. Cuny, B. Hofauer, P. Monteyrol, and J. Micoulaud-Franchi report no disclosures relevant to the manuscript. Go to Neurology.org/N for full disclosures.

Study Funding

This study was possible through a COPSIT grant from the University Hospital of Bordeaux.

Authors

Affiliations & Disclosures

Pierre Philip, MD, PhD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Inspire inc., speaker honoraria
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
inspire inc., scientific consultancies for research development and exchanges with health care authorities
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Clemens Heiser, MD, PhD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
(1) Galvani Bioelectronics (Middlesex, United Kingdom)
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1)Inspire Medical Systems (Maple Grove, USA): funding for travel/speaker honoraria, research funding (2) Sutter Medizintechnik (Freiburg, Germany): funding for travel/speaker honoraria, research funding (3) Neuwirth Medical Products (Obernburg, Germany): funding for travel/speaker honoraria, research funding (4) Storz (Tuttlingen, Germany): speaker honoraria
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
(1) Inspire Medical Systems (Maple Grove, USA)
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Stéphanie Bioulac, MD, PhD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Ellemarije Altena, PhD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Guillame Penchet, MD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Emmanuel Cuny, MD, PhD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1) medtronic fees for the travel to the international congress of neuromdulation in edinburg in 2017 (2) Boston scientifique visiting the compagnie to los angeles 2017
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
(1) vygon SA stocks an member of the supervisory board of the company Stock/Stock Options, Medical Equipment & Materials: (1)stocks from Vygon SA
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Benedikt Hofauer, MD, PhD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
1. Inspire Medical Systems, honoraria for speaking engagements.
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
1. Galvani Bioelectronics, consultancy contract
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Pierre-Jean Monteyrol, PhD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Jean-Arthur Micoulaud-Franchi, MD, PhD
From the Université de Bordeaux (P.P., S.B., E.A., J.-A.M.-F.), SANPSY, USR 3413, Bordeaux; CNRS-SANPSY (P.P., S.B., E.A., J.-A.M.-F.), USR 3413, Bordeaux; Clinique du Sommeil (P.P., S.B., P.-J.M., J.-A.M.-F.), CHU Pellegrin, Place Amélie-Raba-Léon, Bordeaux, France; Service de Neuro-chirurgie (E.A., E.C.), CHU de Bordeaux, Place Amélie Raba-Léon, Bordeaux, France; and Department of Otolaryngology, Head and Neck Surgery (C.H., B.H.), Technical University of Munich, Klinikum Rechts der Isar, Hals-Nasen-Ohren-Klinik, Munich, Germany.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author

Notes

Correspondence Pr. Philip [email protected]
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

Author Contributions

Study concept and design: P.P., P.-J.M., J.-A.M.-F. Acquisition of data: P.P., S.B., G.P., E.C., P.-J.M., J.-A.M.-F. Analysis and interpretation: P.P., C.H., E.A., E.C., B.H., P.-J.M., J.-A.M.-F. Critical revision of the manuscript for important intellectual content: P.P., S.B., E.A., G.P., E.C., B.H., P.-J.M., J.-A.M.-F. Study supervision: P.P., J.-A.M.-F.

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    • Clemens Heiser,
    • Joachim Maurer,
    Overview of Different HN-Stimulation Systems: Inspire, Upper Airway Stimulation in Obstructive Sleep Apnea, (109-122), (2022).https://doi.org/10.1007/978-3-030-89504-4_9
    Crossref
    • Clemens Heiser,
    • Armin Steffen,
    • Patrick J. Strollo,
    • Claire Giaie-Miniet,
    • Olivier M. Vanderveken,
    • Benedikt Hofauer,
    Hypoglossal nerve stimulation versus positive airway pressure therapy for obstructive sleep apnea, Sleep and Breathing, 27, 2, (693-701), (2022).https://doi.org/10.1007/s11325-022-02663-6
    Crossref
    • David Kent,
    • Jeffrey Stanley,
    • R. Nisha Aurora,
    • Corinna G. Levine,
    • Daniel J. Gottlieb,
    • Matthew D. Spann,
    • Carlos A. Torre,
    • Katherine Green,
    • Christopher G. Harrod,
    Referral of adults with obstructive sleep apnea for surgical consultation: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment, Journal of Clinical Sleep Medicine, 17, 12, (2507-2531), (2021).https://doi.org/10.5664/jcsm.9594
    Crossref
    • Jin Chen,
    • Shu Lin,
    • Yiming Zeng,
    An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment, Frontiers in Cardiovascular Medicine, 8, (2021).https://doi.org/10.3389/fcvm.2021.647071
    Crossref
    • Peter M. Baptista Jardin,
    • Guillermo Plaza,
    Surgery, Neurological Modulation of Sleep, (325-338), (2020).https://doi.org/10.1016/B978-0-12-816658-1.00033-8
    Crossref
    • A. Steffen,
    • J. U. Sommer,
    Die HNO-spezifische operative Therapie bei schlafbezogenen AtmungsstörungenENT-specific surgical therapy for sleep-related breathing disorders, Somnologie, 23, 3, (172-177), (2019).https://doi.org/10.1007/s11818-019-00218-8
    Crossref
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