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April 24, 2019

Stroke incidence in young adults according to age, subtype, sex, and time trends

Merel S. Ekker, MD https://orcid.org/0000-0001-6598-2218, Jamie I. Verhoeven, BSc, Ilonca Vaartjes, PhD, Koen M. van Nieuwenhuizen, MD, Catharina J.M. Klijn, MD, PhD, and Frank-Erik de Leeuw, MD, PhDAuthors Info & Affiliations
May 21, 2019 issue
92 (21) e2444-e2454
https://doi.org/10.1212/WNL.0000000000007533
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Abstract

Objective

To investigate incidence of stroke and its subtypes in young adults, according to sex and age, and to study trends over time.

Methods

We established a nationwide cohort through linkage of national registries (hospital discharge, cause of death, and population register) with patients aged 18–50 years and those ≥50 years with first-ever ischemic stroke, intracerebral hemorrhage, or unspecified stroke, using ICD-9/ICD-10 codes between 1998 and 2010 in the Netherlands. Outcomes were yearly incidence of stroke stratified by age, sex, and stroke subtype, its changes over time, and comparison of incidence in patients 18–50 years to patients ≥50 years.

Results

We identified 15,257 patients (53% women; mean age 41.8 years). Incidence increased exponentially with age (R2 = 0.99) and was higher for women than men, most prominently in the youngest patients (18–44 years). The relative proportion of ischemic stroke increased with age (18–24 years: 38.3%; 44–49 years: 56.5%), whereas the relative proportion of intracerebral hemorrhage decreased (18–24 years: 34.0%; 44–49 years: 18.3%). Incidence of any stroke in young adults increased (1998: 14.0/100,000 person-years: 2010: 17.2; +23%; p < 0.001), driven by an increase in those aged over 35 years and ischemic stroke incidence (46%), whereas incidence decreased in those ≥50 years (329.1%–292.2%; −11%; p = 0.009).

Conclusions

Incidence of any stroke in the young increases with age in patients over 35, is higher in women than men aged 18–44 years, and has increased by 23% in one decade, through an increase in ischemic stroke. Incidence of intracerebral hemorrhage is comparable for women and men and remained stable over time.

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Information & Authors

Information

Published In

Neurology®
Volume 92 • Number 21 • May 21, 2019
Pages: e2444-e2454
PubMed: 31019103

Copyright

© 2019 American Academy of Neurology.

Publication History

Received: October 5, 2018
Accepted: January 22, 2019
Published online: April 24, 2019
Published in issue: May 21, 2019

Permissions

Request permissions for this article.

Disclosure

M. Ekker and J. Verhoeven report no disclosures relevant to the manuscript. I. Vaartjes is funded by the Dutch Heart Foundation for project Facts and Figures. The Julius Center and the Dutch Heart Foundation had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. K. Nieuwenhuizen reports no disclosures relevant to the manuscript. C. Klijn is supported by a clinical established investigator grant from the Dutch Heart Foundation (2012T077) and by an ASPASIA grant from The Netherlands Organisation for Health Research and Development, ZonMw (grant number 015008048). F. de Leeuw is supported by a clinical established investigator grant from the Dutch Heart Foundation (2014 T060) and by a VIDI innovational grant from The Netherlands ZonMw (grant number 016126351). Go to Neurology.org/N for full disclosures.

Study Funding

No targeted funding reported.

Authors

Affiliations & Disclosures

Merel S. Ekker, MD* https://orcid.org/0000-0001-6598-2218
From the Department of Neurology (M.S.E., J.I.V., C.J.M.K., F.-E.d.L.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen; and Julius Center for Health Sciences and Primary Care (I.V.) and Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (K.M.v.N., C.J.M.K.), University Medical Center Utrecht, the Netherlands.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Jamie I. Verhoeven, BSc*
From the Department of Neurology (M.S.E., J.I.V., C.J.M.K., F.-E.d.L.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen; and Julius Center for Health Sciences and Primary Care (I.V.) and Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (K.M.v.N., C.J.M.K.), University Medical Center Utrecht, the Netherlands.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Ilonca Vaartjes, PhD
From the Department of Neurology (M.S.E., J.I.V., C.J.M.K., F.-E.d.L.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen; and Julius Center for Health Sciences and Primary Care (I.V.) and Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (K.M.v.N., C.J.M.K.), University Medical Center Utrecht, the Netherlands.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
European Journal of Preventive Cardiology, deputy editor, 2014, 2015, 2016, 2017
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Dutch Heart Foundation grant Facts and Figures
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Koen M. van Nieuwenhuizen, MD
From the Department of Neurology (M.S.E., J.I.V., C.J.M.K., F.-E.d.L.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen; and Julius Center for Health Sciences and Primary Care (I.V.) and Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (K.M.v.N., C.J.M.K.), University Medical Center Utrecht, the Netherlands.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Catharina J.M. Klijn, MD, PhD‡
From the Department of Neurology (M.S.E., J.I.V., C.J.M.K., F.-E.d.L.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen; and Julius Center for Health Sciences and Primary Care (I.V.) and Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (K.M.v.N., C.J.M.K.), University Medical Center Utrecht, the Netherlands.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Have been giving a lecture during a teaching course supported by Boehringer Ingelheim, received payment for hours spent (2014). Topic not related to the current study. Have given lecture for a scientific presentation supported by Boehringer (2015), received payment for hours spent. Topic not related to the current study. Have given lecture for a scientific presentation supported by Penumbra (2016), received payment for hours spent. Topic not related to the current study.
Editorial Boards:
1.
Associate editor for European Stroke Journal.
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
CJMK is supported by a clinical established investigator grant of the Dutch Heart Foundation (No 2012T077), and an Aspasia grant from the Netherlands Organisation for Health Research and Development, ZonMw (015008048).
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Frank-Erik de Leeuw, MD, PhD‡
From the Department of Neurology (M.S.E., J.I.V., C.J.M.K., F.-E.d.L.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen; and Julius Center for Health Sciences and Primary Care (I.V.) and Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (K.M.v.N., C.J.M.K.), University Medical Center Utrecht, the Netherlands.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
VIDI innovational grant from The Netherlands Organisation for Health Research and Development (ZonMw grant 016?126?351)
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
supported by a clinical established investigator grant of the Dutch Heart Foundation (grant number 2014 T060)
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author

Notes

Correspondence Dr. de Leeuw [email protected]
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
*
These authors contributed equally to this work as co–first authors.
‡
These authors contributed equally to this work as co–last authors.

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