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September 13, 2019

Mechanical thrombectomy in acute stroke
Paying attention to white matter hyperintensities

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Nils Henninger, MD, PhD https://orcid.org/0000-0002-3883-5623, and Johannes Kaesmacher, MDAuthors Info & Affiliations
October 15, 2019 issue
93 (16) 691-692
https://doi.org/10.1212/WNL.0000000000008310
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Abstract

Approximately 30% of acute ischemic strokes are due to large vessel occlusion (LVO), the most devastating ischemic stroke type.1 Modern mechanical thrombectomy (MT) approaches have substantially improved patient outcomes compared to best medical therapy.2,3 Recent studies have provided evidence that using imaging indices of acute tissue viability can provide a more individualized approach and expand the treatment window of MT.4 Such innovative neuroimaging selection of patients for MT represents a paradigm shift in acute stroke care because it is based on the underlying pathophysiology driving stroke evolution, rather than depending only on time.

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References

1.
Lakomkin N, Dhamoon M, Carroll K, et al. Prevalence of large vessel occlusion in patients presenting with acute ischemic stroke: a 10-year systematic review of the literature. J Neurointerv Surg 2019;11:241–245.
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Information & Authors

Information

Published In

Neurology®
Volume 93 • Number 16 • October 15, 2019
Pages: 691-692
PubMed: 31519777

Copyright

© 2019 American Academy of Neurology.

Publication History

Published online: September 13, 2019
Published in issue: October 15, 2019

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Disclosure

Dr. Henninger serves on the advisory board of Omniox, Inc and serves as a consultant to Astrocyte Pharmaceuticals, Inc. Dr. Henninger serves on the editorial board of Stroke, Translational Neuroscience Reviews, Stroke Research and Treatment, and World Journal of Neurology. Dr. Kaesmacher reports no disclosures. Go to Neurology.org/N for full disclosures.

Study Funding

Dr. Henninger is supported by K08NS091499 and R44NS076272 from the National Institute of Neurologic Disorders and Stroke of the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Authors

Affiliations & Disclosures

Nils Henninger, MD, PhD https://orcid.org/0000-0002-3883-5623
From the Departments of Neurology (N.H.) and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester; and University Institute of Diagnostic and Interventional Neuroradiology (J.K.) and University Institute of Diagnostic, Interventional and Pediatric Radiology (J.K.), University Hospital Bern, Inselspital, University of Bern, Switzerland.
Disclosure
Scientific Advisory Boards:
1.
(1) Omniox, Inc.
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
(1) Stroke, Editor, 9 years (2) Translational Neuroscience Reviews, Associate Editor, 3 years (3) Stroke Research and Treatment, Editor, 2 years (4) World Journal of Neurology, Editor, 6 years
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
(1) Astrocyte Pharmaceuticals, Inc.
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
(1) National Institute of Neurological Disorders and Stroke of the National Institutes of Health, K08NS091499, PI, 4 year. (2) National Institute of Neurological Disorders and Stroke of the National Institutes of Health, R44NS076272
Research Support, Academic Entities:
1.
(1) UMass Medical School, Healey Public Service Award 2019 (2) UMass Medical School, Riccio Neuroscience Fund 2018
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Johannes Kaesmacher, MD
From the Departments of Neurology (N.H.) and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester; and University Institute of Diagnostic and Interventional Neuroradiology (J.K.) and University Institute of Diagnostic, Interventional and Pediatric Radiology (J.K.), University Hospital Bern, Inselspital, University of Bern, Switzerland.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Travel Funding, Stryker & Pfizer
Editorial Boards:
1.
Frontiers in Neurology, Associate Editor (Research Topic: Tandem occlusion) BMC Neurology, Associate Editor
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Swiss Stroke Society: Research Grant 2018 ("Förderpreis"). Swiss Academy of Medical Sciences/Bangerter-Foundation: Young Talents In Clinical Research - YTCR 28/17
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author

Notes

Correspondence Dr. Henninger [email protected]
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

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