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Abstract

We thank Dr. Chen for his comment. We included neuromyelitis optica spectrum disorder (NMOSD) patients with longitudinal visual-evoked potential (VEP) data covering ≥3 months. We calculated the changes per year using regression analysis. For eyes with <12 months longitudinal OCT follow-up available, the change rate was interpolated. However, as interpolation of data with short intervals can lead to amplification of measurement variability, we also performed a more conservative subanalysis including only eyes with ≥12 months interval between VEP measurements. For this subanalysis, only 58% and 69% of eyes were available for the investigation of the rates of change of latencies and amplitudes, respectively. Of note, it has previously been reported that the amplitudes show a stronger variability of measurement compared to latencies.1,2 Therefore, we believe that the sample size was not sufficient to achieve statistical significance in the subanalysis. Moreover, the prominent outliers of amplitude changes of eyes with <12 months of follow-up are likely to result from amplification of measurement variability and should be interpreted with caution. On the other hand, the latency findings show consistent and reliable increases also in the conservative ≥12 months subanalysis, thus representing the main finding of our study and a better parameter to investigate chronic changes.

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References

1.
Tello C, De Moraes CG, Prata TS, et al. Repeatability of short-duration transient visual evoked potentials in normal subjects. Doc Ophthalmol 2010;120:219–228.
2.
Thomae E, Niklas A, Sebraoui H, et al. Improving test-retest variability of visual-evoked responses in multiple sclerosis: implications for trial design. J Clin Neurophysiol 2010;27:270–273.

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Published In

Neurology®
Volume 95Number 13September 29, 2020
Pages: 610
PubMed: 32989121

Publication History

Published online: September 28, 2020
Published in print: September 29, 2020

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Marius Ringelstein
(Düsseldorf, Germany)
Jens Harmel
(Düsseldorf, Germany)
Hanna Zimmermann
Friedemann Paul
Axel Haarmann
Martin W. Hümmert
Corinna Trebst
Christoph Schroeder
Ilya Ayzenberg
Kerstin Hellwig
Tania Kümpfel
Sven Jarius
Brigitte Wildemann
Martin Weber
Hannah Pellkofer
Luise Röpke
Christian Geis
Nele Retzlaff
Uwe Zettl
Michael Deppe
Kim Young
(Hamburg-Eppendorf, Germany)
Jan-Patrick Stellmann
(Hamburg-Eppendorf, Germany)
Matthias Kaste
Pawel Kermer
Wael Marouf
Florian Lauda
Hayrettin Tumani
Sasha Klistorner
Hans-Peter Hartung
(Düsseldorf, Germany)

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