The Challenging Puzzle of Migraine, Age, and Vascular Health
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The association between migraine and cardiovascular risk is well established but poorly understood.1 Migraine, especially with aura, is an independent risk factor for stroke and ischemic heart disease.1 Although potential migraine-related mechanisms may explain a specific brain vulnerability to ischemia, the pathophysiologic pathways leading to an increased risk of cardiovascular events remain unclear. Because of differences in methodology and definitions, current evidence is conflicting and does not provide unbiased support to the role of traditional risk factors as drivers of cardiovascular risk in patients with migraine.2
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Lipton RB, Reed ML, Kurth T, Fanning KM, Buse DC. Framingham-based cardiovascular risk estimates among people with episodic migraine in the US population: results from the American Migraine Prevalence and Prevention (AMPP) study. Headache. 2017;57(10):1507-1521.
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Published In
Neurology®
Volume 99 • Number 16 • October 18, 2022
Pages: 681-682
Copyright
© 2022 American Academy of Neurology.
Publication History
Received: May 22, 2022
Accepted: June 22, 2022
Published online: August 19, 2022
Published in print: October 18, 2022
Disclosure
S. Sacco reports personal fees as speaker or advisor from Abbott, Allergan-AbbVie, AstraZeneca, Eli Lilly, Lundbeck, Novartis, Novo Nordisk, Pfizer, and Teva; research grants from Allergan, Novartis, and Uriach; nonfinancial support from Abbott, Allergan, Bayer, Bristol-Myers Squibb, Daiichi Sankyo, Eli Lilly, Lundbeck, Medtronic, Novartis, Pfizer, Starmed, and Teva; and fees for CME/education from Medscape and Neurodiem Ology Medical Education; she is a member of the Editorial Boards of Neurology, Stroke, European Stroke Journal, International Journal of Stroke, and the Journal of Headache and Pain, and she is the Chief Section Editor for the section Headache and Neurogenic Pain in Frontiers of Neurology. L.A. Sposato reports speaker and consulting honoraria from Boehringer Ingelheim, Pfizer, Bayer, and Gore; research grants from Boehringer Ingelheim and Bayer; he is a member of the Editorial Boards of Neurology, Stroke, and the Journal of the American Heart Association. Go to Neurology.org/N for full disclosures.
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