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August 17, 2023

Infarct Analysis to Explain Outcomes of Perinatal Stroke
Leveling the Mountain Voxel by Voxel

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Darrah Haffner, MD, and Warren D. Lo, MDAuthors Info & Affiliations
October 10, 2023 issue
101 (15) 641-642
https://doi.org/10.1212/WNL.0000000000207776
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Abstract

Neonatal arterial ischemic stroke (NAIS) is the most common form of stroke in children, potentially leading to long-term neurologic sequelae, including cerebral palsy (CP), epilepsy, cognitive impairment, and behavioral problems. Predicting outcomes of NAIS is a challenge. One child with NAIS may have significant impairment, whereas another with a similar infarct may be almost asymptomatic. A tool that could predict a child's outcome based on infarct characteristics (location and volume) would be a powerful aid in the clinic. Multiple studies have shown that infarct characteristics can predict motor impairment such as CP; however, most of these did not use the most sophisticated and sensitive imaging techniques.1-3 The correlation between language and cognitive skills has been less clear.

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References

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Information & Authors

Information

Published In

Neurology®
Volume 101 • Number 15 • October 10, 2023
Pages: 641-642
PubMed: 37591775

Copyright

© 2023 American Academy of Neurology.

Publication History

Received: June 24, 2023
Accepted: June 28, 2023
Published online: August 17, 2023
Published in issue: October 10, 2023

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Disclosure

The authors declare no disclosures relevant to this editorial. Go to Neurology.org/N for full disclosures.

Study Funding

The authors report no targeted funding.

Authors

Affiliations & Disclosures

Darrah Haffner, MD*
From the Department of Pediatrics and Neurology (D.H., W.D.L.), The Ohio State University; and Nationwide Children's Hospital (D.H., W.D.L.), Columbus, OH.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
None
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
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Warren D. Lo, MD*
From the Department of Pediatrics and Neurology (D.H., W.D.L.), The Ohio State University; and Nationwide Children's Hospital (D.H., W.D.L.), Columbus, OH.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
None
Editorial Boards:
1.
I am on the editorial board of Neurology since 2019.
Patents:
1.
NONE
Publishing Royalties:
1.
Pediatric Stroke and Cerebrovascular Disorders, published 2011
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
ACTIVE*Title: Seizures and Children's Outcomes after Stroke (SCOUTS)Project Number: R01 NS119896Name of PD/PI: Christine Fox*Source of Support: NIHProject/Proposal Start and End Date: 09/2021-08/2026* Total Award Amount (including Indirect Costs): $20,205* Person Months (Calendar/Academic/Summer) per budget period.*Title: StrokeNet I-ACQUIRE 12-month follow-upProject Number: 3U01NS106655Name of PD/PI: Sharon Landesman-Ramey*Source of Support: NIHProject/Proposal Start and End Date: 06/2021-01/2024* Total Award Amount (including Indirect Costs): $52,744*Title: National Pediatric Rehabilitation Resource CenterProject Number: 1P2CHD101912-02Name of PD/PI: Sharon Landesman-Ramey*Source of Support: NIH-NINDSProject/Proposal Start and End Date: 05/2020-04/2025* Total Award Amount (including Indirect Costs): $342,771*Title: Brain Vascular Malformation Clinical Research Network (BVMC)Project Number: 2U54NS065705Name of PD/PI: Helen Kim*Source of Support: NIH-NINDSProject/Proposal Start and End Date: 08/2019-06/2024* Total Award Amount (including Indirect Costs): $15,200*Title: Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)Project Number: 1U01NS106655Name of PD/PI: Lo, W.D.*Source of Support: NIH-NINDSProject/Proposal Start and End Date: 02/2019-01/2024* Total Award Amount (including Indirect Costs): $435,553*Title: Network of Excellence in Neuroscience Clinical Trials Center at The Ohio State UniversityProject Number: 5U24NS107205Name of PD/PI: Steven Kolb*Source of Support: NIH-NINDSProject/Proposal Start and End Date: 07/2018-06/2023* Total Award Amount (including Indirect Costs): $133,943*Title: BAM-Development of Upper Extremity Behavioral Assessment Methods for Reach, Grasp, Mobility and Rehabilitation*Status of Support: Active Project Number: 1R01HD107730 – 01A1Name of PD/PI: Heathcock*Source of Support: The Ohio State University / NIH
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
Abbott Lab 2023Amgen 2023Becton Dickson 2023Cardinal Health 2023GE Healthcare 2023Illumina 2023McKesson 2023Merck 2023Moderna 2023Pfizer 2023Walgreens Boots 2023
Legal Proceedings:
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Notes

Correspondence Dr. Lo [email protected]
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
*
These authors contributed equally to this work.

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