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Research Article
October 1, 2024
Open Accessclass of evidenceeditorialpodcastLetter to the Editor

Eculizumab Use in Neuromyelitis Optica Spectrum Disorders
Routine Clinical Care Data From a European Cohort

Marius Ringelstein, MD https://orcid.org/0000-0003-3618-8407, Susanna Asseyer, MD https://orcid.org/0000-0001-6289-1791, Gero Lindenblatt, MD, Katinka Fischer, MD, Refik Pul, MD https://orcid.org/0000-0002-8940-9317, Jelena Skuljec, PhD, Lisa Revie, MD, Show All , Katrin Giglhuber, MD, Vivien Häußler, MD https://orcid.org/0000-0002-7787-7391, Michael Karenfort, MD, Kerstin Hellwig, MD https://orcid.org/0000-0003-4467-9011, Friedemann Paul, MD https://orcid.org/0000-0002-6378-0070, Judith Bellmann-Strobl, MD https://orcid.org/0000-0003-2615-1643, Carolin Otto, MD, Klemens Ruprecht, MD https://orcid.org/0000-0003-1962-6014, Tjalf Ziemssen, MD https://orcid.org/0000-0001-8799-8202, Alexander Emmer, MD, Veit Rothhammer, MD, Florian T. Nickel, MD, Klemens Angstwurm, MD, Ralf Linker, MD, Sarah A. Laurent, MD, Clemens Warnke, MD https://orcid.org/0000-0002-3510-9255, Sven Jarius, MD, Mirjam Korporal-Kuhnke, MD, Brigitte Wildemann, MD, Stephanie Wolff, MD https://orcid.org/0009-0001-1974-1090, Maria Seipelt, MD, Yavor Yalachkov, MD https://orcid.org/0000-0002-0805-771X, Nele Retzlaff, MD, Uwe K. Zettl, MD, Paulus S. Rommer, MD https://orcid.org/0000-0001-5209-6647, Markus C. Kowarik, MD, Jonathan Wickel, MD https://orcid.org/0000-0002-5854-3759, Christian Geis, MD https://orcid.org/0000-0002-9859-581X, Martin W. Hümmert, MD https://orcid.org/0000-0002-5928-2343, Corinna Trebst, MD, Makbule Senel, MD, Ralf Gold, MD https://orcid.org/0000-0002-7223-3052, Luisa Klotz, MD https://orcid.org/0000-0001-5439-9633, Christoph Kleinschnitz, MD https://orcid.org/0000-0002-1650-8875, Sven G. Meuth, MD, PhD https://orcid.org/0000-0003-2571-3501, Orhan Aktas, MD https://orcid.org/0000-0002-2020-9210, Achim Berthele, MD https://orcid.org/0000-0001-9650-6222, and Ilya Ayzenberg, MD https://orcid.org/0009-0007-9491-2180 for the German Neuromyelitis Optica Study Group (NEMOS)Authors Info & Affiliations
November 12, 2024 issue
103 (9)

Abstract

Background and Objectives

Attack prevention is crucial in managing neuromyelitis optica spectrum disorders (NMOSDs). Eculizumab (ECU), an inhibitor of the terminal complement cascade, was highly effective in preventing attacks in a phase III trial of aquaporin-4 (AQP4)-IgG seropositive(+) NMOSDs. In this article, we evaluated effectiveness and safety of ECU in routine clinical care.

Methods

We retrospectively evaluated patients with AQP4-IgG+ NMOSD treated with ECU between December 2014 and April 2022 at 20 German and 1 Austrian university center(s) of the Neuromyelitis Optica Study Group (NEMOS) by chart review. Primary outcomes were effectiveness (assessed using annualized attack rate [AAR], MRI activity, and disability changes [Expanded Disability Status Scale {EDSS}]) and safety (including adverse events, mortality, and attacks after meningococcal vaccinations), analyzed by descriptive statistics.

Results

Fifty-two patients (87% female, age 55.0 ± 16.3 years) received ECU for 16.2 (interquartile range [IQR] 9.6 – 21.7) months. Forty-five patients (87%) received meningococcal vaccination before starting ECU, 9 with concomitant oral prednisone and 36 without. Seven of the latter (19%) experienced attacks shortly after vaccination (median: 9 days, IQR 6–10 days). No postvaccinal attack occurred in the 9 patients vaccinated while on oral prednisone before starting ECU and in 25 (re-)vaccinated while on ECU. During ECU therapy, 88% of patients were attack-free. The median AAR decreased from 1.0 (range 0–4) in the 2 years preceding ECU to 0 (range 0–0.8; p < 0.001). The EDSS score from start to the last follow-up was stable (median 6.0), and the proportion of patients with new T2-enhancing or gadolinium-enhancing MRI lesions in the brain and spinal cord decreased. Seven patients (13%) experienced serious infections. Five patients (10%; median age 53.7 years) died on ECU treatment (1 from myocardial infarction, 1 from ileus with secondary sepsis, and 3 from systemic infection, including 1 meningococcal sepsis), 4 were older than 60 years and severely disabled at ECU treatment start (EDSS score ≥ 7). The overall discontinuation rate was 19%.

Discussion

Eculizumab proved to be effective in preventing NMOSD attacks. An increased risk of attacks after meningococcal vaccination before ECU start and potentially fatal systemic infections during ECU—particularly in patients with comorbidities—must be considered. Further research is necessary to explore optimal timing for meningococcal vaccinations.

Classification of Evidence

This study provides Class IV evidence that eculizumab reduces annualized attack rates and new MRI lesions in AQP4-IgG+ patients with NMOSD.

Introduction

Neuromyelitis optica spectrum disorders (NMOSDs) are predominantly anti-aquaporin-4 (AQP4)-IgG-mediated inflammatory diseases of the CNS, characterized by relapsing attacks affecting the optic nerves, the spinal cord, and the brainstem/brain.1-4 Attack prevention is crucial to avoid disability accumulation.5 Various therapeutic strategies such as CD19-specific or CD20-specific monoclonal antibody-mediated B-cell depletion,6,7 interleukin-6 (IL-6) receptor blockade,8,9 and complement inhibition10,11 were successful in phase II/III trials, particularly in AQP4-IgG+ patients with NMOSDs. This led to the approval of inebilizumab, rituximab (RTX, only in Japan), satralizumab, eculizumab (ECU), and ravulizumab (RAV) for AQP4-IgG+ NMOSD in many countries worldwide.12 However, data on clinical experience with these agents outside of controlled trials are scarce.
In NMOSDs, AQP4-IgG binding to the astrocytic water channel activates the complement pathway, which induces astrocyte death13 and perivascular complement deposition associated with prominent vascular fibrosis.14 ECU, a humanized monoclonal antibody, binds to the terminal complement protein C5 and inhibits its cleavage into C5a and C5b. Because the risk of meningococcal infections has been estimated to be 2,000-fold higher in patients treated with ECU than in the untreated population,15 meningococcal vaccination or antibiotic prophylaxis is mandatory for patients treated with complement inhibitors.
ECU has first been approved for treating paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) in 2007 and 2011, respectively.16 In neurologic disorders, ECU has been licensed for generalized myasthenia gravis (gMG)17 and was first successfully investigated in NMOSDs in an open-label pilot trial with 14 patients in 2009/2010.18 In the pivotal PREVENT trial on AQP4-IgG+ NMOSD, ECU (n = 96 patients) led to a 94.2% attack risk reduction compared with placebo (n = 47)10 with sustained effects in the open-label extension (OLE) phase.19 The rate of treatment-related serious adverse events (SAEs) was 8.0 in 100 patient-years, including severe infections in 18.2% of patients.19,20 Of interest, serious infections occurred less frequently with ECU than with placebo, regardless of concomitant immunosuppressive medications or previous RTX use.21 There was 1 reported death under ECU and azathioprine (AZA) in the PREVENT trial categorized as possibly related to ECU treatment,10 and there were no fatalities during the OLE.19
This study evaluated the effectiveness and safety of ECU and meningococcal vaccinations in a large NMOSD cohort.

Methods

The study has been performed within the Neuromyelitis Optica Study Group (NEMOS).22 On informed consent, NEMOS includes AQP4-IgG+ and seronegative patients with NMOSD, patients with NMOSD suspicious clinical syndromes, and patients with myelin oligodendrocyte glycoprotein antibody-associated diseases in Germany, Austria, and Switzerland. Of this cohort, we included all ECU-treated AQP4-IgG+ patients with NMOSD from 21 neurologic departments in Germany (n = 20) and Austria (n = 1) from December 2014 until April 2022 in the analysis, irrespective of the disease or treatment duration (Figure 1).
Figure 1 Flowchart Illustrating the Recruitment of 52 Eculizumab (ECU)-Treated AQP4-IgG Seropositive Patients With NMOSD for This Study From the Neuromyelitis Optica Study Group (NEMOS)
AQP4-IgG = aquaporin-4-immunoglobulin G; MOGAD = myelin oligodendrocyte glycoprotein antibody-associated disease; NMOSDs = neuromyelitis optica spectrum disorders.
Clinical and paraclinical data were obtained by the treating physicians and entered in the NEMOS database. All data were analyzed retrospectively by chart review. Patients were continuously treated at the contributing centers with regular assessments of clinical (attacks and Expanded Disability Status Scale [EDSS] score) and paraclinical (MRI, AQP4-IgG, and other laboratory tests) data. AQP4-IgG was investigated exclusively by cell-based assays.23-25
Our analyses focused on ECU safety and effectiveness, given as annualized attack rate (AAR), active or new/progressive lesions on MRI, and longitudinal disability changes (EDSS). An attack was defined as “a definitely new neurologic symptom” or “clear acute worsening of previous neurologic deficits” with objective clinical signs, lasting for ≥ 24 hours and attributable to an inflammatory CNS event. Last available MRIs of the brain and the cervicothoracic spinal cord, before and during ECU therapy, were classified as “nonactive” or “active” according to the absence/presence of new/enlarging T2-enhancing or contrast-enhancing T1 lesions, respectively. No standardized MRI protocols were used. MRI scans were evaluated by 2 radiologists (at least 1 neuroradiologist) during regular clinical workup. Safety aspects comprised infusion-related reactions, serious infections, exacerbation of autoimmune comorbidities, and fatalities. Considering previously reported exacerbation of autoimmune diseases after meningococcal vaccination,26-29 we further focused our analysis on disease activity in patients vaccinated before and after starting ECU.

Statistical Analysis

The AAR before ECU treatment was calculated by dividing the total number of attacks within the past 2 years before the initial ECU administration by 2. In patients with a disease duration of <2 years before ECU treatment, we also categorically divided the total number of attacks by 2 because there were no attacks before the disease onset. Owing to the individual lengths of ECU treatment, the AAR during ECU therapy denotes the number of attacks in proportion to the exact treatment duration. Attacks occurring within 21 days after vaccination were defined as postvaccinal attacks.
The cohort was described using absolute and relative frequencies, along with the mean or median and appropriate measures of variability such as SD, interquartile range (IQR), the interval between the lower and upper quartile, range, and minimum (min) and maximum (max). In most cases, values were not normally distributed; hence, nonparametrical tests were used. To test for significant differences between medians of 2 unpaired groups, for example, vaccinated vs unvaccinated patients, the Wilcoxon test for independent samples was applied. In the case of paired data, such as AAR before ECU start and AAR under ECU therapy, the Wilcoxon signed-rank test was used. In normally distributed data, t tests or Welch tests were applied. To assess the correlation between categorical variables, Fisher exact tests were used in cases where cell numbers were less than 5 while χ2 tests were used otherwise. The results were presented in terms of odds ratios (ORs) along with their corresponding 95% confidence intervals. Otherwise, statistical test results are presented as p values with alpha = 0.05 as the predetermined significance level. Version 4.0.5 of the R Statistics package was used for statistical analysis.

Standard Protocol Approvals, Registrations, and Patient Consents

Ethical approval to conduct this study was obtained from the institutional review board of the Heinrich-Heine University Düsseldorf (#3419) and from each participating center by their local institutional review boards according to ICH/GCP. All patients provided written informed consent for data collection.

Data Availability

Anonymized data not published within this article will be made available by request from any qualified investigator.

Results

Cohort Description

We included data of 52 patients (87% female, 90% White) with AQP4-IgG+ NMOSD in this study (Table 1) fulfilling the international consensus criteria for NMOSD.4 Fifty patients were adults, and 2 patients were younger than 18 years at disease manifestation (6.2 and 17.3 years), 1 still younger than 18 years at ECU start. Thirteen patients had autoimmune comorbidities, including systemic lupus erythematosus (SLE; n = 4), Hashimoto thyroiditis (n = 4), Sjögren syndrome (n = 2), myasthenia gravis (n = 2), type 1 diabetes mellitus (n = 2), Grave disease, sarcoidosis, membranous glomerulonephritis, systemic scleroderma, rheumatoid arthritis, vitiligo, hyperthyroidism, immune thrombopenia, and antiphospholipid syndrome (1 each).
Table 1 Cohort Description and Previous Immunotherapies
 AQP4-IgG+, n = 52
Ethnicity, n (%) 
 White47 (90)
 Latin American1 (2)
 African1 (2)
 Asian2 (4)
 Arabian1 (2)
Sex, n: female/male (% female)45/7 (87)
NMOSD based on 2015 criteria: yes/no (% yes)52/0 (100)
Age at disease manifestation in y: mean (SD)48.3 (17.0)
ECU-treated pediatric patients (% yes)1/52 (2%)
Disease duration before ECU in y: median (IQR)4.1 (0.7–7.3)
All attacks before ECU, n: median (IQR)3.0 (2.0–5.0)
Attacks during past 2 y before ECU, n: median (IQR)2.0 (1.0–3.0)
Attacks under last immunotherapy, n: median (IQR)1.0 (0.0–2.0)
AAR in the 2 y before ECU, median (IQR)1.0 (0.5–1.5)
Age at ECU start in y: mean (SD)55.0 (16.3)
BMI at ECU start, median (IQR)26.0 (23.6–28.6)
EDSS score at the last follow-up before ECU, median (IQR)6.0 (3.0–7.4)
ECU treatment duration in y: median (IQR)1.3 (0.8–1.8)
All immunotherapies before ECU, n (%) 
 Azathioprine13 (25)
 Belimumab1 (2)
 Cyclophosphamide4 (8)
 Fingolimod2 (4)
 Glatiramer acetate3 (6)
 Hydroxychloroquine1 (2)
 IVIG9 (17)
 IVMP quarterly1 (2)
 Long-term PLEX3 (6)
 Methotrexate4 (8)
 Mitoxantrone1 (2)
 Mycophenolate mofetil4 (8)
 Natalizumab2 (4)
 Rituximaba31 (60)
 Steroids6 (12)
 Tocilizumab5 (10)
 Intrathecal triamcinolone1 (2)
Abbreviations: AAR = annualized attack rate; AQP4-IgG = aquaporin-4-immunoglobulin G; BMI = body mass index; ECU = eculizumab; EDSS = Expanded Disability Status Scale; IQR = interquartile range; IVIGs = IV immunoglobulins; IVMP = IV methylprednisolone; NMOSDs = neuromyelitis optica spectrum disorders; PLEX = plasma exchange.
a
Eleven of 52 patients received rituximab in the past 6 mo before ECU start, so initial additional effects of the ongoing B-cell depletion are possible in this subgroup.

Disease Course Before Eculizumab Treatment

The median disease duration before ECU start was 4.1 (IQR 0.7–7.3) years. At disease manifestation, the mean age was 48.3 years (SD ± 17.0); at ECU start, the mean age was 55.0 years (SD ± 16.3). Before ECU start, patients had experienced a median of 3.0 attacks (range 1–21). Considering the past 2 years before ECU start, 2.0 attacks (median; min 0, max 8 attacks) were recorded (Table 1, Figure 2). The median AAR (IQR) was 1.3 (0.5–3.1) for the overall disease duration and 1.0 (0.5–1.5) during the 2 years before ECU treatment, respectively. The median EDSS score at ECU start was 6.0 (IQR 3.0–7.3), with 26 patients (50%) having an EDSS score ≥ 6.0 (range 6.0–9.5). Baseline brain MRI (bMRI) and spinal cord MRI (scMRI) scans were available in 47 and 41 of the 52 patients, respectively. The last available bMRI was performed at 2.2 (IQR 0.8–5.2) months and scMRI at 1.8 (IQR 0.9–6.0) months before treatment initiation. New, enlarging, or active lesions were found in 18 of 47 bMRI scans (39%) and 24 of 41 scMRI scans (59%) before treatment initiation.
Figure 2 Disease Courses of All 52 AQP4-IgG Seropositive Patients With NMOSD Before and During Eculizumab (ECU) Treatment, Highlighting Previous Immunotherapies, Add-on Treatments During ECU, and Every Attack, Indicated by Red and Black Diamonds

Immunotherapies Before Eculizumab Treatment

Most patients (39/52, 75%) had received at least 1 immunotherapy before ECU (1 [n = 17], 2 [n = 10], 3 or more immunotherapies [n = 12]; Table 1). The most frequent treatment before ECU was RTX, given to 31 patients (60%; administered with 1.000 mg every 6 months in 20 of 31 patients). Within the past 24, 12, and 6 months before ECU initiation, 26 (50%), 21 (40%), and 11 (21%) of the 52 patients were treated with RTX, respectively. The second and third most frequent immunotherapies were AZA (25%) and IV immunoglobulins (IVIGs; 17%). 13 patients (25%) were treatment-naive before ECU start (Figure 2).

Initiation of Eculizumab Therapy

ECU was initiated in most patients (34/52; 65%) because of recent (<3 months) attack activity (33/34) or an asymptomatic enlarging lesion on MRI (1/34). 10 of these 34 patients were treatment-naive, and 24 were switched from another immunotherapy (13 from RTX, 4 from AZA, 2 from IVIG, 3 from oral prednisolone, 1 from tocilizumab, and 1 from methotrexate and hydroxychloroquine). In the remaining 18 patients, ECU was started because of attacks further back (≥3 months) under the last therapy (n = 10), as a first therapy (n = 3), and because of side effects of previous immunotherapy (n = 1), refusal to reimburse RTX costs by the insurance company (n = 1), wish for pregnancy (n = 1), or unknown reasons (n = 2).

Attack Rate, MRI, and Disability Changes During Eculizumab Therapy

39 patients (75%) were treated with ECU monotherapy, and 13 (25%) received add-on oral prednisolone (n = 7), AZA (n = 3), mycophenolate mofetil (MMF; n = 2), or MMF and prednisolone (n = 1), partly administered in the context of other autoimmune comorbidities (n = 3). The median observation period on ECU treatment was 16.2 (IQR 9.6–21.7, range 2.0–85.8) months; 43 patients were treated for at least 6 months and 36 patients for at least 12 months.
A total of 6 attacks in 6 of 52 patients (12%) occurred during ECU therapy after a median of 5.6 (IQR 3.3–12.9) months (mean 8.7, SD 7.6) during a median observation period of 18.1 (IQR 15.5–20.4) months on ECU. These attacks included optic neuritis (n = 2), myelitis (n = 2), and brainstem encephalitis (n = 2). 4 of the 6 relapsing patients were receiving the standard ECU maintenance dose (1,200 mg every 2 weeks), 1 adult received 900 mg, and the pediatric patient received 600 mg biweekly. None of the 6 relapses occurred within the first 30 days of starting ECU (median 165 days, range 72–626), rather ruling out a possible therapeutic lag. 2 of 39 patients (5%) relapsed during ECU monotherapy and 4 of 13 patients (31%) under ECU with add-on therapy. 2 of the 6 attacks were treated with IV methylprednisolone (IVMP) only, 2 required IVMP plus apheresis therapy, 1 required oral prednisolone, and 1 patient did not receive attack therapy.
The median AAR in the total cohort decreased from 1.0 (IQR 0.5–1.0) in the 2 years before ECU start to 0 (IQR 0) under ECU (p < 0.001; Figure 3A). 88% of the patients were attack-free during ECU therapy. Similarly, the median (IQR) AAR in the subgroup of patients treated with ECU for at least 12 months (n = 36, only 35 longitudinal AAR value pairs available) decreased from 1 (0.5–1.5) in the 2 years before ECU start to 0 (0) under ECU (p < 0.01). The median (IQR) AAR of patients who received RTX within 6 months of starting ECU (n = 11; 8 with ECU monotherapy) vs those who did not was similar, with an AAR of 1 (0.5–1.0) vs 1 (0.5–1.5) (p = 1) within 2 years before start of ECU and 0 (0 – 0.3) vs 0 (0) (p = 0.06) under ECU, respectively.
Figure 3 Significant Decrease of the Annualized Attack Rate (AAR) Between the 2 Years Before Eculizumab (ECU) Initiation and During ECU Treatment (p < 0.001; A) Clinical Stabilization Measured By a Constant Median Expanded Disability Status Scale (EDSS; Longitudinal Data Available in 45 Patients) Score Between ECU Start (6.0) and the Last Follow-Up During ECU Treatment (6.0; p = 0.08; B)
Longitudinally, the median EDSS scores between ECU start and the last follow-up during ECU treatment were stable (6.0; p = 0.08) (Figure 3B). They remained unchanged in 22 of 45 (49%), improved in 15 of 45 (33%), and deteriorated in 8 of 45 (18%) patients (in 4 of these 8 patients in the context of an attack). Longitudinal EDSS data were not available in 7 patients, and 1 of them experienced an attack during ECU therapy. Seven of 8 patients with EDSS score deterioration received ECU with add-on immunotherapy, corresponding to an EDSS score progression in 7 of 13 patients (54%) in the “add-on-”treated group. In other 4 of these 13 patients, the EDSS score improved, and in 2 of 13, it remained unchanged.
Follow-up bMRI scans and scMRI scans during ECU treatment were available in 27 and 28 patients, respectively, and were obtained 10.0 months (median, IQR 7.2–21.2) and 11.6 months (median, IQR 6.3 – 20.5) after ECU start. The proportion of patients with new or enlarging T2-enhancing or contrast-enhancing T1 MRI lesions decreased significantly compared with the last MRI before ECU start (44% vs 7%; p < 0.05 for bMRI and 64% vs 16%; p < 0.001 for scMRI; Figure 4A+B).
Figure 4 Significant Decrease of New or Contrast-Enhancing Lesions in 27 Patients With Available Longitudinal Brain MRI Scans (p = 0.006; A) and 25 Patients With Longitudinal Spinal Cord MRI Scans (p < 0.001; B) Before and During Eculizumab (ECU) Treatment

Meningococcal Vaccination and Attack Activity

Forty-five patients (87%) received at least 1 vaccination against Neisseria meningitidis before ECU start. Thirty-six (80%) of these patients received both vaccines against serogroups ACW135Y and serogroup B, 4 (9%) only against serogroup B, 4 (9%) only against serogroups ACW135Y, and 1 (2%) only against serogroup C. Twenty-five patients (48%) were first vaccinated (n = 5) or re-vaccinated (n = 20) against meningococcal infection during ECU treatment. 2 patients (4%) did not receive any vaccination against Neisseria meningitidis (eTable 1). In 21 patients, antibiotics were administered because of an incomplete or missing immunization against meningococcal disease.
In total, 7 attacks occurred in temporal association with meningococcal vaccination (median: 9 days thereafter, IQR: 6–10; Table 2). Notably, all 7 attacks manifested in patients vaccinated before the initiation of ECU therapy. Five attacks occurred after simultaneous vaccination against serogroups ACW135Y and serogroup B while 1 attack each was noted after vaccination against serogroup B and serogroups ACW135Y. None of these patients received concomitant oral prednisone during the vaccination. All 7 attacks were confirmed by MRI and required apheresis therapy.
Table 2 Detailed Information of 7 Patients Who Experienced Postvaccinal Attacks
Patient no.1234567
N. meningitidis vaccination before ECU startYesYesYesYesYesYesYes
Serogroups vaccinated againstB, ACW135YB, ACW135YB, ACW135YB, ACW135YBACW135YB, ACW135Y
First vaccination against N. meningitidisYesYesYesYesYesYesYes
Time between vaccination and attack10 d8 d18 d11 d2 d5 d9 d
Type of attackThoracal myelitisCervical longitudinal myelitisOptic neuritis + longitudinal myelitis at multiple levelsBrainstem syndromeCervical myelitisThoracal myelitisCervicothoracal longitudinal myelitis
MRI-confirmed attackYesYesYesYesYesYesYes
Outcome of attack treatmentPartial remission under PLEX + alternating steroidsFull remission under PLEXPartial remission under PLEX + RTX initiationPartial remission under PLEXPartial remission under steroids + PLEXPartial remission under PLEXPartial remission under PLEX
Immunotherapy before ECU       
 Medication, protocolnoneRTX, biannually, 1000 mgIVIG, monthly, 1–2g/kg body weight for 2–5 dRTX, initiation with 1000 mgnoneRTX, biannually, 1000 mgTCZ, monthly, 8 mg/kg body weight
 Time between last infusion and vaccinationNA139 d242 d231 dNA292 d17 d
 Time between last acute treatment (IV steroids and/or PLEX) and vaccination59 d (PLEX and IV steroids)60 d (PLEX)200 d (IV steroids)16 d (PLEX)16 d (PLEX)84 d (PLEX)8 d (PLEX)
AAR in the past 2 y before vaccination0.5121120.5
Add-on therapynonenonenoneMMF, 1,000 mg/dnonenonenone
Further vaccinations       
 Serogroups vaccinated againstBBBBB, ACW135YBnone
Abbreviations: AAR = annualized attack rate; ECU = eculizumab; EDSS = Expanded Disability Status Scale; MMF = mycophenolate mofetil; NA = not applicable; N. meningitidis = Neisseria meningitidis; PLEX = plasma exchange; RTX = rituximab; TCZ = tocilizumab.
By contrast, none of the 9 patients who received meningococcal vaccination before ECU therapy and concurrently took oral prednisone (in varying doses) suffered subsequent attacks. Of these patients, 8 were simultaneously vaccinated against serogroups ACW135Y and serogroup B while 1 patient was only vaccinated against serogroup B.
In addition, no temporarily associated relapses were observed in 25 patients vaccinated or boostered against meningococcal disease during ECU therapy. Overall, 7 of 36 patients (19.4%) who had been vaccinated before ECU start without concomitant prednisone therapy experienced attacks.
The risk of postvaccinal attacks was not associated with the presence of additional comorbid autoimmune diseases (OR 1.16, CI95% [0.18,10.53]).
There was no difference in the overall number of vaccinations administered within 4 weeks of the initial meningococcal vaccination between patients who experienced postvaccinal attacks and those who did not (in both groups: median: 2, range: 1–3 and 1–4 vaccinations, respectively). There was no difference in median AAR in the previous 2 years before vaccination (median: 1, range: 0.5–2 in the group with postvaccinal relapses vs median: 0.5, range: 0–2 in the relapse-free group, p = 0.19). The comparison of patients without concomitant prednisolone use during the vaccination showed similar results (median AAR 1, range: 0–2 vs 1, range 0.5–2, respectively). The proportion of patients with recent attacks in the preceding 3 months before vaccination was also similar among those with and without postvaccinal attacks (57% vs 48%, p = 0.70).
Thirteen patients were further vaccinated against pneumococcal disease (8 before ECU and 5 during ECU therapy). Only 1 patient experienced an attack 3 weeks after pneumococcal vaccination, performed during ECU therapy.

Infusion-Related Reactions, SAEs, and Mortality

Infusion-related reactions were reported in 5 patients and comprised mild exanthema on the infusion arm, port occlusion and paravasation, nausea and vomiting, fever and shivering, and allergic reaction with generalized pruritus and periocular edema (leading to treatment discontinuation). The 2 latter patients with fever and allergic reaction received antiallergic medication before consecutive infusions.
Seven patients (13%) experienced serious infections requiring hospitalization (2 on ECU monotherapy and 5 with add-on immunotherapy with oral steroids, AZA, and MMF). Two were diagnosed with pneumonia (1 with sepsis); 2 with urosepsis (1 with fatal secondary subarachnoid hemorrhage); 1 with Candida sepsis (fatal course); 1 with meningococcal infection (fatal course); and 1 with multiple infections including erysipelas, pyelonephritis, and thoracic varicella zoster infection. The patient with meningococcal sepsis (serogroup B) had completed the recommended meningococcal vaccination against serogroups ACW135Y and serogroup B under oral corticosteroid therapy 20 months before. This patient also suffered from SLE and, therefore, received add-on treatment with MMF for several months at the time of vaccination (Table 3). Two other patients had recurrent fever episodes of unknown origin; however, no infection has been reported. Two patients experienced exacerbation of SLE (during ECU monotherapy in one case and during ECU therapy with concomitant 5 mg prednisolone in another), leading to ECU discontinuation in both patients.
Table 3 Demographic and Clinical Aspects of 5 Fatalities During Eculizumab Treatment
Patient no.12345
SexFemaleMaleFemaleFemaleFemale
AQP4-IgG serostatusPosPosPosPosPos
MOG-IgG serostatusNegNegNegNegNeg
NMOSD based on 2015 criteriaYesYesYesYesYes
Disease duration before ECU (y)> 150 – 10 – 11 – 5> 20
AAR in the 2 y before ECU1.50.50.51.50.5
Relapses under last immunotherapyYesNANAYesNo
EDSS score at ECU start8.58.08.50.07.0
ECU treatment duration (mo)4.812.013.220.426.4
Age at death (decade)6th8th7th2nd8th
Time between last ECU infusion and death (d)3024215712
Immunotherapies before ECUFIN, NTZ, RTX, TCZSteroidAZAAZA, CYC, IVIG, MMF, RTX, TCZAZA, GLAT, IVIG, MIT, RTX
Autoimmune comorbidities before ECUNoneNoneNoneSLENone
Comedication at the time of deathSteroidNoneAZAMMFSteroid
Cause of deathCandida sepsis, pneumoniaSepsis after mechanical and paralytic ileusUrosepsis with Klebsiella pneumoniae, secondary aneurysmatic SAHMeningococcal sepsis (serogroup B, sequence type 35 complex), fulminant NMOSD attackMyocardial infarction
Vaccination against serogroups ACW135Y before ECUNoYesNoYesaYes
Vaccination against serogroup B before ECUNoYesNoYesaYes
Vaccination against serogroup C before ECUNoNoYesNoNo
Abbreviations: AAR = annualized attack rate; AQP4-IgG = aquaporin-4-immunoglobulin G; AZA = azathioprine; CYC = cyclophosphamide; DM = diabetes mellitus; ECU = eculizumab; EDSS = Expanded Disability Status Scale; FIN = fingolimod; GLAT = glatiramer acetate; IVIGs = IV immunoglobulins; MIT = mitoxantrone; MMF = mycophenolate mofetil; MOG-IgG = myelin-oligodendrocyte-glycoprotein immunoglobulin G; NA = not applicable; NAT = natalizumab; neg = negative; NMOSDs = neuromyelitis optica spectrum disorders; pos = positive; RTX = rituximab; SAH = subarachnoid hemorrhage; SLE = systemic lupus erythematosus; TCZ = tocilizumab.
a
Patient 4 received MMF and IVIG at the time of vaccination
In total, 5 of 52 patients (10%), including 1 child (median age 54 years; range 13–73), died after 1.2 (median; IQR: 1.1–1.9) years on ECU treatment. One person died of myocardial infarction, 1 of ileus with secondary sepsis, and 3 in the context of systemic infections, including 1 of meningococcal sepsis (Table 3). Four of these 5 patients had severe disease courses (EDSS score ≥ 7) while the pediatric patient had no neurologic deficits at ECU start. Four of 5 patients died within 4 weeks of the last ECU infusion and the pediatric patient 57 days after the last infusion due to meningococcal sepsis.
Of the remaining 47 patients, 9 (19%) discontinued ECU treatment after a median treatment duration of 0.8 years (IQR: 0.4–1.2). Reasons for treatment discontinuation were recurrent UTIs with urosepsis (n = 1), disease activity (n = 1; disease progression on MRI (myelitis) associated with SLE exacerbation), infusion-related burden and exacerbation of previous autoimmune comorbidities (n = 1, SLE and autoimmune thrombopenia), infusion-related burden (n = 1), infusion-related allergic reaction (n = 1), refusal of meningococcal vaccination (n = 1), and (unknown) personal reasons (n = 3).
Two of 9 discontinuing patients died 4 and 16 months after ECU cessation: 1 patient had planned to prolong ECU treatment interval for personal reasons, experienced an NMOSD attack, and died several weeks thereafter (no further information available). The other person with infusion-related allergic reactions during ECU treatment was switched to RTX and then, again owing to infusion-related intolerance, to AZA and died severely disabled.
This study provides Class IV evidence that eculizumab reduces annualized attack rates and new MRI lesions in AQP4-IgG+ patients with NMOSD.

Discussion

In this study, we retrospectively analyzed routine clinical care data of a European cohort of AQP4-IgG+ patients with NMOSD treated with eculizumab. Despite a high baseline attack activity and disability (median EDSS score 6.0), the median AAR decreased substantially and 88% of patients remained attack-free during ECU treatment. These results are similar to previous findings in the pilot study on ECU in AQP4-IgG+ NMOSD (n = 14; 86% of patients remained attack-free; ARR decreased from 3.0 to 0),18 in the PREVENT trial (n = 96; 97% attack-free; ARR decreased from 1.9 to 0),10 and for RAV in the CHAMPION-NMOSD study (n = 58; 100% attack-free; ARR decreased from 1.9 to 0).11 Notably, add-on immunosuppressants showed no advantage regarding the AAR compared with ECU monotherapy in our cohort, although our sample size was too small to draw conclusions. An investigation in a larger sample size would be necessary to detect a protective or potentially detrimental influence of add-on immunotherapy on disease activity. The heterogeneity of comorbidities and related add-on therapies precluded such statistical analyses in this study.
The decrease in brain and spinal cord MRI activity corroborates the clinical effectiveness of ECU. These findings are novel because MRI data have not yet been systematically analyzed in previous ECU and RAV trials. Nevertheless, asymptomatic MRI activity is not always a marker of disease activity in NMOSD.30 Similar to the PREVENT10 and CHAMPION-NMOSD studies,11 EDSS scores remained stable on ECU despite a substantially higher baseline disability in our cohort (median EDSS score of 6.0 vs 4.0 and 3.25, respectively). Our routine clinical care data thus confirm the high therapeutic effectiveness of ECU in AQP4-IgG+ NMOSD.
Concerning safety, previous controlled trials and registries have revealed infusion-related reactions, headaches, nasopharyngitis, upper respiratory tract infection and UTI, back pain and diarrhea, nausea, and arthralgia as the most common adverse events of ECU in patients with NMOSD.20 Severe infections, including bacterial and fungal sepsis (fatal in some cases), have also been reported in patients treated with ECU.31 In our cohort, 7 patients (13%) experienced serious infections, including 1 case of meningococcal sepsis despite previous vaccination and 4 cases of nonmeningococcal sepsis. A high level of preexisting disability and immobility and higher age and concomitant immunosuppressive therapy were potential risk factors of serious infections under treatment with ECU in our cohort in line with a recent consensus article32; however, (subsequently fatal) sepsis also occurred in a pediatric patient in the absence of neurologic disability.
Probably, the most relevant and novel safety finding of our study was the observation of disease attacks temporally associated with meningococcal vaccinations, performed before ECU initiation. Notably, a high number of attacks within the 2-week time window between the meningococcal vaccination and ECU start (or shortly thereafter) had already been reported in 4 of 14 patients (29%) in the ECU pilot study.18 Concomitant oral prednisone during vaccination before ECU start and vaccination after ECU initiation were not associated with postvaccinal attacks in this cohort. Moreover, the relapse rate in the past 2 years and previous attacks in the 3 months before vaccination were also not associated with a higher risk of postvaccinal attacks, suggesting that attack clustering is unlikely to be a causative factor. Despite the limited number of patients vaccinated against pneumococcal infection, only 1 attack has been observed during ECU treatment, indirectly indicating that postvaccinal attacks seem to be more frequently associated with meningococcal vaccines, given before ECU start and without concomitant steroid therapy.
Considering the retrospective nature of this study and the limited number of patients analyzed, data from larger and, ideally, prospective cohorts are needed to clarify whether meningococcal vaccinations might put patients at risk of NMOSD attacks. Mechanisms that specifically underlie an increased attack activity in NMOSD after meningococcal vaccination are unknown. However, the activation of autoimmune and autoinflammatory diseases after vaccination is a well-known phenomenon, especially in women and in patients with more than 1 autoimmune disease.26 Single cases and case series of SLE,27 bullous pemphigoid,28 and Guillain-Barré syndrome29 after different meningococcal vaccinations were previously reported. By contrast, no disease exacerbation has been observed in a systematic study of juvenile idiopathic arthritis.33
The European eculizumab product information warns of potential disease deterioration due to complement activation after meningococcal vaccinations, and Canadian recommendations report on possible complement activation specifically in the context of vaccination against meningococcal serogroup B.34 However, because vaccination against serogroups ACW135Y and serogroup B is mandatory in patients subjected to anticomplement therapy in most countries worldwide, these warnings are of little clinical value. Alternatively, starting complement inhibitors on prophylactic antibiotics and vaccinating later might be a safer approach, enabling both prompt initiation of ECU treatment and safe vaccinations.
Sufficient meningococcal vaccine response remains another highly relevant safety aspect in therapeutic complement inhibition. Despite full vaccination against serogroups ACW135Y and serogroup B before the first ECU infusion, the pediatric patient from our cohort experienced fulminant meningococcal sepsis 1.7 years later, leading to ECU discontinuation, followed by a fatal NMOSD attack (case 4, Table 3). A possible supporting reason in this individual case was the MMF-treated SLE comorbidity. Indeed, infections with encapsulated bacteria during complement blockade have been reported in different indications despite previous vaccination.35 In NMOSD, this includes 1 patient from the ECU pilot study who developed meningococcal sepsis 2 months after her initial ECU infusion,18 1 patient from the PREVENT-OLE study with a Neisseria gonorrhoeae infection,19 and 2 patients in the CHAMPION-NMOSD trial suffering from meningococcal infections after 21 and 483 days of RAV treatment, respectively.11 By contrast, neither the PREVENT study nor a 2-year postmarketing surveillance from Japan observed meningococcal infections.10,36 The substantially higher overall incidence of meningococcal infections in Europe and the United States seems to be the most plausible explanation for these differences.37 Further studies on vaccination responses and predictors of meningococcal infection despite vaccination in patients treated with complement inhibitors seem highly warranted.
Five patients (10%) from our cohort died during ECU treatment. This finding contrasts with previous observations on complement inhibitors in NMOSD because there were no fatalities in the pilot study (during ECU treatment), PREVENT-OLE study, CHAMPION-NMOSD trial,11,18,19 and a recent Japanese, manufacturer-funded postmarketing surveillance.36 Only 1 patient (0.96%) from the PREVENT study died of infectious pleural empyema under ECU and AZA treatment, classified as probably related to the trial medication.10 One large Japanese study on the safety profile of ECU in 1,055 patients with PNH, aHUS, or gMG reported 40 patients (3.8%) who died because of SAEs, 34 of them due to serious infections, including 2 cases with meningococcal sepsis.31 More recently, 1 additional patient with NMOSD with concomitant SLE was reported, who developed type B insulin resistance and severe Klebsiella pneumoniae pneumonia during ECU treatment and died of sepsis-related multiorgan failure 18 months after ECU initiation.38
In our cohort, 4 of 5 patients who died during/shortly after ECU treatment were aged older than 50 years and severely disabled at ECU treatment start (EDSS score ≥ 7). In sum, we suppose that severe disability, immobility, and higher age at disease onset contributed to an increased risk of infections and mortality in our cohort. Thus, overall disability, age, autoimmune comorbidities, and previous or concomitant immunosuppression should be carefully considered when making decisions to start ECU.
Our study is limited by its retrospective nature and the heterogeneity in data collection from 21 participating centers (contributing 1–7 patients per center; eTable 2) with, in consequence, partly incomplete data sets in some cases and by the limited number of patients in some subgroup analyses. The homogeneous ethnicity (90% White) and the relatively brief observation period on ECU (median 16.2 months) limit the generalizability to other populations and restrict the ability to draw definitive conclusions regarding its long-term safety and effectiveness. Our study may thus underestimate the risks associated with the use of ECU. The strength of our study is that it is one of the largest ECU NMOSD cohorts reported so far, including older patients and those with severe disability in a clinical routine setting rather than in the more strictly controlled setting of a phase III study. Given the safety signals observed in this study, prospective, nonmanufacturer-funded registries are urgently needed.
Eculizumab therapy was associated with reduced attack rate and stable EDSS scores in our cohort, confirming clinical trial data. However, in this study, ECU treatment goes along with a higher risk of serious and potentially fatal complications than reported in the clinical trials, including meningococcal and other systemic infections. Further factors, including potential immune deficiency after multiple pretreatments, higher age, disability, and concomitant diseases, should be included in individual infection risk assessment.
The observation of an increased risk of attacks temporarily associated with meningococcal vaccination before ECU initiation in patients not co-treated with oral steroids is a critical finding with possible implications for treatment initiation and patient management. Later vaccination after ECU initiation seems to be safer regarding postvaccinal attacks. However, the number of patients included was too small to draw definite conclusions. Moreover, further studies are needed to evaluate the protective role of concomitant steroids during vaccination before ECU or RAV treatment and the effect of prednisone and/or other immunotherapies on the efficacy of meningococcal vaccination and on potential immune markers (e.g., serum bactericidal antibody test) that may predict the degree of protection against meningitis/meningococcal sepsis.
In summary, this study provides important insights into the effectiveness and safety of eculizumab in NMOSD and highlights the importance of carefully evaluating the risk-benefit profile in older patients with severe disability.

Glossary

AAR
annualized attack rate
BfR
Bundesinstitut für Risikobewertung
bMRI
brain MRI
DFG
Deutsche Forschungsgemeinschaft
EDSS
Expanded Disability Status Scale
G-BA
Gemeinsamer Bundesausschuss
gMG
generalized myasthenia gravis
IQR
interquartile range
IVMP
intravenous methylprednisolone
NEMOS
Neuromyelitis Optica Study Group
NMOSD
neuromyelitis optica spectrum disorder
OLE
open-label extension
OR
odds ratios
PNH
paroxysmal nocturnal hemoglobinuria
SAE
serious adverse event
scMRI
spinal cord MRI

Appendix 1 Authors

NameLocationContribution
Marius Ringelstein, MDDepartment of Neurology, Medical Faculty; Department of Neurology, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data
Susanna Asseyer, MDExperimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data
Gero Lindenblatt, MDDepartment of Neurology, Johanna Etienne Hospital, Neuss, GermanyDrafting/revision of the manuscript for content, including medical writing for content; analysis or interpretation of data; additional contributions (in addition to 1 or more of the above criteria)
Katinka Fischer, MDDepartment of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, GermanyDrafting/revision of the manuscript for content, including medical writing for content; analysis or interpretation of data; additional contributions (in addition to 1 or more of the above criteria)
Refik Pul, MDCenter for Translational Neuro- and Behavioral Sciences, University Medicine Essen, University of Duisburg-Essen, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Jelena Skuljec, PhDCenter for Translational Neuro- and Behavioral Sciences, University Medicine Essen, University of Duisburg-Essen, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Lisa Revie, MDDepartment of Neurology, University Hospital, Münster, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Katrin Giglhuber, MDDepartment of Neurology, School of Medicine and Health, Technical University of Munich, Klinikum rechts der Isar, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Vivien Häußler, MDDepartment of Neurology and Institute of Neuroimmunology and MS (INIMS), University Medical Center Hamburg-Eppendorf, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Michael Karenfort, MDDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Kerstin Hellwig, MDDepartment of Neurology, St. Josef-Hospital, Ruhr University Bochum, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Friedemann Paul, MDExperimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Lindenberger Weg 80; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Judith Bellmann-Strobl, MDDepartment of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Carolin Otto, MDDepartment of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Klemens Ruprecht, MDDepartment of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Tjalf Ziemssen, MDDepartment of Neurology, Center of Clinical Neuroscience, University Hospital, Dresden, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Alexander Emmer, MDDepartment of Neurology, University Hospital, Halle, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Veit Rothhammer, MDDepartment of Neurology, University Hospital, Erlangen, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Florian T. Nickel, MDDepartment of Neurology, University Hospital, Erlangen, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Klemens Angstwurm, MDDepartment of Neurology, University Hospital, Regensburg, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Ralf Linker, MDDepartment of Neurology, University Hospital, Regensburg, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Sarah A. Laurent, MDDepartment of Neurology, University Hospital, Köln, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Clemens Warnke, MDDepartment of Neurology, University Hospital, Köln, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Sven Jarius, MDDepartment of Neurology, Molecular Neuroimmunology Group, University of Heidelberg, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Mirjam Korporal-Kuhnke, MDDepartment of Neurology, Molecular Neuroimmunology Group, University of Heidelberg, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Brigitte Wildemann, MDDepartment of Neurology, Molecular Neuroimmunology Group, University of Heidelberg, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Stephanie Wolff, MDDepartment of Neurology, University Hospital, Gießen, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Maria Seipelt, MDDepartment of Neurology, University Hospital, Marburg, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Yavor Yalachkov, MDDepartment of Neurology, University Hospital, Frankfurt, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Nele Retzlaff, MDDepartment of Neurology, University Hospital, Rostock, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Uwe K. Zettl, MDDepartment of Neurology, University Hospital, Rostock, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Paulus S. Rommer, MDDepartment of Neurology, Medical University of Vienna, AustriaDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Markus C. Kowarik, MDDepartment of Neurology, University Hospital, Tübingen, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Jonathan Wickel, MDSection of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Christian Geis, MDSection of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Martin W. Hümmert, MDDepartment of Neurology, Hannover Medical School, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Corinna Trebst, MDDepartment of Neurology, Hannover Medical School, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Makbule Senel, MDDepartment of Neurology, University Hospital, Ulm, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Ralf Gold, MDDepartment of Neurology, St. Josef-Hospital, Ruhr University Bochum, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Luisa Klotz, MDDepartment of Neurology, University Hospital, Münster, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Christoph Kleinschnitz, MDCenter for Translational Neuro- and Behavioral Sciences, University Medicine Essen, University of Duisburg-Essen, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Sven G. Meuth, MD, PhDDepartment of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data
Orhan Aktas, MDDepartment of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data
Achim Berthele, MDDepartment of Neurology, School of Medicine and Health, Technical University of Munich, Klinikum rechts der Isar, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data
Ilya Ayzenberg, MDDepartment of Neurology, St. Josef-Hospital, Ruhr University Bochum, GermanyDrafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data

Appendix 2 Coinvestigators

Coinvestigators are listed at Neurology.org/N.

Footnote

Editorial, page e209970

Supplementary Material

File (coinvestigators.pdf)
File (etable 1.pdf)
File (etable 2.pdf)

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Letters to the Editor
12 November 2024
Reader Response: Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data From a European Cohort
Sean J. Pittock| Department of Neurology | Mayo Clini
Sami Fam | Alexion, AstraZeneca Rare Disease

We read with great interest the recent article by Ringelstein et al.,1 in which the authors addressed concern that meningococcal vaccines may trigger relapses in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD). We agree with the observation in the editorial accompanying the paper2 that additional data could shed light on the strength of this association.

Many patients in the study had several attacks within a short time frame before eculizumab initiation. However, data regarding the timing of patients’ vaccinations in relation to their most recent attack was not provided. The authors reported that 3 of 7 patients with postvaccinal attacks had exposure to plasma exchange within 16 days before meningococcal vaccination. This suggests that these patients may have experienced an attack shortly before vaccination. It was not specified whether the attack criteria included a preceding 30-day period of clinical stability, as in previous retrospective studies.3,4 Were the postvaccinal attack types the same as or different from the most recent prevaccination attack type? Imaging details (e.g., MRI) confirming the attacks could help determine if lesions were completely new or related to previous attacks (pseudorelapse). In a recent analysis of >350 patients from clinical trials (CHAMPION-NMOSD and PREVENT) and real-world data from Japan’s eculizumab postmarketing surveillance, relapse incidence within 4 weeks of meningococcal vaccination was low (0.7%-10.6%).5 Further details are needed to better understand the true relationship between vaccinations and subsequent NMOSD attacks.

References:

  1. Ringelstein M, Asseyer S, Lindenblatt G, et al. Eculizumab use in neuromyelitis optica spectrum disorders: routine clinical care data from a European cohort. 2024;103(9):e209888. doi:10.1212/WNL.0000000000209888
  2. Marignier R, Kunchok A. Eculizumab in AQP4-IgG NMOSD: efficacy in the real world and potential warning of meningococcal vaccines. 2024;103(9):e209970. doi:10.1212/WNL.0000000000209970
  3. Luo W, Shi Z, Kong L, et al. Patterns of neuromyelitis optica spectrum disorder attacks in different age groups and sexes depending on the status of immunosuppressive therapy: a retrospective cohort study. Eur J Neurol. 2024;31(3):e16178. doi:10.1111/ene.16178
  4. Demuth S, Guillaume M, Bourre B, et al. Treatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study. J Neuroinflammation. 2022;19(1):62. doi:10.1186/s12974-022-02420-2
  5. Fam S, Parks B, Yajima T, et al. Incidence of relapses after meningococcal vaccination in clinical trials and real-world evidence of eculizumab and ravulizumab in AQP4-Ab+ NMOSD. Mult Scler. 2024;30(3_Suppl):347. doi: 10.1177/13524585241269219

Author disclosures are available upon request ([email protected]).

31 October 2024
Author Response: Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data From a European Cohort
Marius Ringelstein| Department of Neurology | Medical Faculty, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf
Susanna Asseyer | Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsm
Gero Lindenblatt| Department of Neurology | Johanna Etienne Hospital
Katinka Fischer| Department of Neurology | Medical Faculty, Heinrich-Heine-University Düsseldorf
Orhan Aktas| Department of Neurology | Medical Faculty, Heinrich-Heine-University Düsseldorf
Achim Berthele| Department of Neurology | School of Medicine, Technical University of Munich, Klinikum rechts der Isar
Ilya Ayzenberg| Department of Neurology | St. Josef-Hospital, Ruhr University Bochum

We thank Chen and colleagues for their comments on our paper,1 to which we reply as follows:

First, the predominance of White patients in our study is due to the location of the recruiting centers (Germany and Austria). This majority is typical of a European cohort, and our cohort is named as such in the title of our paper. A female majority of up to 9:1 is also common in Europe.2–4 Although the generalizability of our findings to other populations may be limited, we believe the homogeneity and representativeness of our cohort in its specific setting are major strengths.

Second, an analysis of visual impairment was outside the scope of our study. However, we agree that scales and questionnaires addressing vision5 as well as other NMOSD-related symptoms such as pain, depression,6 fatigue, and cognitive dysfunction7 are valuable, as these facets of the disease are not sufficiently covered by the EDSS.

Third, in response to the correspondents’ question regarding how we dealt with missing data: we excluded individuals from sub-analyses when data were missing. Imputation was mostly not an option, such as for MRI data. Certainly, a standardized MRI protocol would have been useful, but the study’s retrospective nature precluded this.

Despite these limitations, our study answered important questions. It confirmed the effectiveness of eculizumab in NMOSD and provided insights into the safety of this treatment in a real-world setting.

References

  1. Ringelstein M, Asseyer S, Lindenblatt G, et al. Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data From a European Cohort. Neurology. 2024;103(9):e209888. doi: 10.1212/WNL.0000000000209888
  2. Hor JY, Asgari N, Nakashima I, et al. Epidemiology of Neuromyelitis Optica Spectrum Disorder and Its Prevalence and Incidence Worldwide. Front Neurol. 2020;11:501. doi: 10.3389/fneur.2020.00501
  3. Gold SM, Willing A, Leypoldt F, Paul F, Friese MA. Sex differences in autoimmune disorders of the central nervous system. Semin Immunopathol. 2019;41(2):177-188. doi: 10.1007/s00281-018-0723-8
  4. Borisow N, Kleiter I, Gahlen A, et al. Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. Mult Scler. 2017;23(8):1092-1103. doi: 10.1177/1352458516671203
  5. Schmidt F, Zimmermann H, Mikolajczak J, et al. Severe structural and functional visual system damage leads to profound loss of vision-related quality of life in patients with neuromyelitis optica spectrum disorders. Mult Scler Relat Disord. 2017;11:45-50. doi: 10.1016/j.msard.2016.11.008
  6. Ayzenberg I, Richter D, Henke E, et al. Pain, Depression, and Quality of Life in Neuromyelitis Optica Spectrum Disorder: A Cross-Sectional Study of 166 AQP4 Antibody-Seropositive Patients. Neurol Neuroimmunol Neuroinflamm. 2021;8(3):e985. doi: 10.1212/NXI.0000000000000985
  7. Hümmert MW, Stern C, Paul F, et al. Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study). Mult Scler. 2023;29(7):819-831.

Author disclosures are available upon request ([email protected]). 

21 October 2024
Reader Response: Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data From a European Cohort
Ting Chen | The Third Clinical Medical College, Zhejiang Chinese Medical University
Siyang Chen | The Third Clinical Medical College, Zhejiang Chinese Medical University
Xianming Lin| Department of Acupuncture | The Third Affiliated Hospital of Zhejiang Chinese Medical University; The Third Clinical Medical College, Zhejiang Chinese Medical University

We read with great interest the study by Ringelstein et al.1 The study provides valuable insights into the real-world efficacy and safety of eculizumab (ECU) for patients with neuromyelitis optica spectrum disorders (NMOSD). However, several limitations warrant further discussion.

Firstly, the study is limited by its geographic scope, with predominantly White participants (90%). Previous research suggests NMOSD incidence is higher in Asian and African populations, with possible variations in disease incidence and treatment response due to genetic, environmental, and socioeconomic factors.2 Additionally, 87% of participants were female. Future studies should aim for a patient population that is more ethnically diverse and that has a balanced ratio regarding participants’ sex to improve generalizability.

Secondly, optic neuritis is a key clinical manifestation of NMOSD,4 and the Expanded Disability Status Scale does not adequately assess visual function.3 Low-contrast visual acuity4 and specific vision-related quality of life questionnaires, such as the National Eye Institute Visual Function Questionnaire,5 could serve as more sensitive tools for detecting and monitoring visual impairment.3 Incorporating these measures would provide a more comprehensive assessment of functional status, particularly regarding visual disability.

Finally, the study does not provide a detailed description of the methods used to address missing data. Strategies such as multiple imputation or sensitivity analysis would strengthen the study’s methodological rigor. Further, the implementation of standardized MRI protocols could enhance the reliability and reproducibility of imaging data in future studies.

References

  1. Ringelstein M, Asseyer S, Lindenblatt G, et al. Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data From a European Cohort. Neurology. 2024;103(9):e209888. doi:10.1212/WNL.0000000000209888
  2. Papp V, Magyari M, Aktas O, et al. Worldwide Incidence and Prevalence of Neuromyelitis Optica: A Systematic Review. Neurology. 2021;96(2):59-77. doi:10.1212/WNL.0000000000011153
  3. KKümpfel T, Giglhuber K, Aktas O, et al. Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) - revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management. J Neurol. 2024;271(1):141-176. doi:10.1007/s00415-023-11910-z
  4. Park SH, Park CY, Shin YJ, Jeong KS, Kim NH. Low Contrast Visual Acuity Might Help to Detect Previous Optic Neuritis. Front Neurol. 2020;11:602193. doi:10.3389/fneur.2020.602193
  5. Sun H, Cui S, Gao F, et al. Eye movement abnormalities in AQP4-IgG positive neuromyelitis optica spectrum disorder. J Neurol Sci. 2018;384:91-95. doi:10.1016/j.jns.2017.11.033

Author disclosures are available upon request ([email protected]).

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Published In

Neurology®
Volume 103Number 9November 12, 2024
PubMed: 39353149

Publication History

Received: January 8, 2024
Accepted: July 26, 2024
Published online: October 1, 2024
Published in print: November 12, 2024

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Disclosure

M. Ringelstein received speaker honoraria from Novartis, Bayer Vital GmbH, Roche, Alexion, Horizon, and Ipsen and travel reimbursement from Bayer Schering, Biogen Idec, Merz, Genzyme, Teva, Roche, Horizon, Alexion, and Merck, none related to this study. S. Asseyer received speaker honoraria from Alexion, Bayer GmbH, and Roche, not related to this study. G. Lindenblatt received travel reimbursement from Bayer Health Care, not related to this study. K. Fischer reports no disclosures relevant to the manuscript. R. Pul received speaker’s and board honoraria from Alexion, Bayer Healthcare, Biogen, Celgene, Janssen Cilag, Merck Serono, Mylan/Viatris, Novartis, Roche, Sanofi Genzyme/Aventis, Stada, and Teva, and received research grants from Herz Burgdorf, Novartis, and Merck, none related to the content of this study. J. Skuljec, L. Lohmann, and K. Giglhuber report no disclosures relevant to the manuscript. V. Häußler reports funding from NEMOS e.V. independent of this project. M. Karenfort received board honoraria from Novartis, not related to the content of this manuscript. K. Hellwig received speaker’s, board honoraria and research support from Biogen Idec, Genzyme, Merck Serono, Novartis, Roche, Hexal, and Teva; and her institution received grant support from Hexal, Biogen Idec, Sanofi-Genzyme, Merck Serono, Novartis, Roche, and Teva. F. Paul serves as an academic editor for PLoS ONE, an associate editor for Neurology: Neuroimmunology and Neuroinflammation, is a member of Novartis OCTIMS study steering committee and MedImmune/Viela Bio steering committee, reports speaker honoraria and travel grants from Bayer, Novartis, Biogen Idec, Teva, Sanofi-Aventis/Genzyme, Merck Serono, Alexion, Chugai, MedImmune, Shire, Roche, Actelion, and Celgene, and consultancies for SanofiGenzyme, BiogenIdec, MedImmune, Shire, Alexion; received research support from Bayer, Novartis, Biogen Idec, Teva, Sanofi-Aventis/Genzyme, Alexion, Merck Serono, the German Research Council (DFG Exc 257), Werth Stiftung of the City of Cologne, the German Ministry of Education and Research (BMBF Competence Network Multiple Sclerosis), Arthur Arnstein Stiftung Berlin, EU FP7 Framework Program (combims.eu), the Arthur Arnstein Foundation Berlin, Guthy Jackson Charitable Foundation, and the National Multiple Sclerosis Society of the USA. J. Bellmann-Strobl has received institutional research support from NEMOS e.V. and Bayer AG, personal compensation from Alexion, speaking honoraria and travel grants from Bayer Healthcare, Horizon, Novartis, and Sanofi-Aventis/Genzyme, and has received compensation for serving on scientific advisory boards for Roche and Merck, all unrelated to the presented work. C. Otto reports no disclosures relevant to the manuscript. K. Ruprecht received research support from Novartis, Merck Serono, the German Ministry of Education and Research, the European Union (821283-2), Stiftung Charité (BIH Clinical Fellow Program), the Guthy Jackson Charitable Foundation, and the Arthur Arnstein Foundation; received speaker honoraria from Novartis and Virion Serion, and received travel grants from the Guthy Jackson Charitable Foundation. T. Ziemssen reports grants and study funding as well as speaking resp. consulting fees from Biogen, BMS, Hexal, Roche, Merck, TEVA, Novartis, Sanofi, and Viatris. A. Emmer received speaker’s and board honoraria from Merck Serono, Roche, Novartis, and Alexion, and research support from Novartis, none related to this manuscript. V. Rothhammer was funded by European Research Council Starting Grant HICI 851693 and a Heisenberg fellowship and Sachmittel support provided by the German Research Foundation (DFG; RO4866-3/1, RO4866-4/1) as well as in transregional and collaborative research centers provided by the DFG (projects 408885537 - TRR 274 and 261193037 - CRC 1181); he also received speaker’s and board honoraria from Alexion, Biogen Idec, Bristol Myers Squibb, Merck, Novartis, Pfizer, Roche, and Sanofi-Aventis. F.T. Nickel received speaker or consultancy honoraria from Alexion, Biogen, Celgene/BMS, Janssen, Merck Serono and Roche, and received grants for congress travel and participation from Biogen and Merck Serono. K. Angstwurm received speaker honoraria from Biogen Idec, travel grants (until 2014) from Alexion, BayerSchering, BiogenIdec, MerckSerono, Novartis, and Teva; and not personal study compensation from Alexion, BayerSchering, Biogen, MerckSerono, Novartis, and Roche, none related to this study. R. Linker received compensation for activities with Biogen, BMS/Celgene, Janssen, Genzyme/Sanofi, Merck, Novartis, and Roche, as well as research support from Biogen and Novartis, none related to this manuscript. S.A. Laurent reports no disclosures relevant to the manuscript. C. Warnke has received institutional support from Novartis, Biogen, Alexion, Janssen, Merck, and Roche. S. Jarius reports no disclosures relevant to the manuscript. M. Korporal-Kuhnke received speaker honoraria from Novartis, Bristol Myers Squibb, and Merck Serono. B. Wildemann received grants from the German Ministry of Education and Research, Deutsche Forschungsgemeinschaft, the Dietmar Hopp Foundation, and the Klaus Tschira Foundation; received grants and personal fees from Merck Serono, Sanofi Genzyme, and Novartis Pharmaceuticals; and received personal fees from Alexion, Bayer, Biogen, INSTAND, and Roche. S. Wolff received honoraria from Mylan and honoraria and research grants from Novartis, outside the submitted work. M. Seipelt reports no disclosures relevant to the manuscript. Y. Yalachkov has been supported by travel grants from Novartis and Sanofi Genzyme, has received an honorarium for active participation in an advisory board by Sanofi Genzyme, and has received speaking honoraria by Roche and Sanofi Genzyme, none of them related to this study. N. Retzlaff reports no disclosures relevant to the manuscript. U.K. Zettl received speaking fees, travel support and/or financial support for research activities from Alexion, Almirall, Bayer, Biogen, Bristol-Myers-Squibb, Janssen, Merck-Serono, Novartis, Octapharm, Roche, Sanofi-Genzyme, Teva, the EU, BMBF, BMWi, and DFG. P.S. Rommer received speaker or consultancy honoraria from AbbVie, Alexion, Almirall, Biogen, Daiichi-Sankyo, Merck, Novartis, Sanofi-Genzyme, Sandoz, and Roche, and received research funding from Biogen, Merck, Roche and Austrian Science Funds (KLI 837-8), none related to this study. M.C. Kowarik has served on advisory boards for and received speaker fees/travel grants from Merck, Sanofi-Genzyme, Novartis, Biogen, Jansen, Alexion, Celgene/Bristol-Myers Squibb, and Roche, and received research grants from Merck, Sanofi-Genzyme and Celgene/Bristol-Myers Squibb, none related to this study. J. Wickel's research is funded by the German Ministry for Education and Research (BMBF) and the Interdisciplinary Center for Clinical Studies (IZKF) Jena, none related to this study. C. Geis received speaker or consultancy honoraria from Alexion, Sobi, and Roche, none related to this study; and his research is funded by the German Ministry for Education and Research (BMBF), Deutsche Forschungsgemeinschaft (DFG), the Schilling Foundation, the Zeiss Foundation, and the Interdisciplinary Center for Clinical Studies (IZKF) Jena. M.W. Hümmert has received research support from Myelitis e.V., travel expenses from Alexion for attending meetings, and speaker honoraria from selpers og. C. Trebst has received honoraria for consultation and expert testimony from Alexio Pharma Germany GmbH and Roche Pharma GmbH; none of this interfered with the current report. M. Senel has received consulting and/or speaker honoraria from Alexion, Bayer, Biogen, Bristol Myers Squibb, Merck, Roche, and Sanofi Genzyme, and has received research funding from the Hertha-Nathorff-Program, none related to the submitted work. R. Gold received speaker’s and board honoraria from Baxter, Bayer Schering, Biogen Idec, CLB Behring, Genzyme, Merck Serono, Novartis, Stendhal, Talecris, and Teva; and his department received grant support from Bayer Schering, Biogen Idec, Genzyme, Merck Serono, Novartis, and Teva, all not related to the content of this manuscript. L. Klotz reports no disclosures relevant to the manuscript. C. Kleinschnitz received speaker honoraria and/or participated in advisory boards for Alexion, Almirall, Amgen, Amicus, Bayer Healthcare, Biogen, Biontech, Biotronik, Boehringer Ingelheim, Bristol Myers-Squibb, Celgene, CSL Behring, Daiichi Sankyo, Desitin, Eisai, Ever Pharma, GE Healthcare, Janssen-Cilag, MedDay Pharmaceuticals, Merck Serono, Mylan/Viatris, Novartis, Pfizer, Roche, Sanofi-Genzyme, Siemens, STADA, Stago, and Teva, none related to the content of this study. S.G. Meuth received honoraria for lecturing and travel expenses for attending meetings from Almirall, Amicus Therapeutics Germany, Bayer Healthcare, Biogen, Celgene, Diamed, Genzyme, MedDay Pharmaceuticals, Merck Serono, Novartis, Novo Nordisk, ONO Pharma, Roche, Sanofi-Aventis, Chugai Pharma, QuintilesIMS, and Teva; and his research is funded by the German Ministry for Education and Research (BMBF), Bundesinstitut für Risikobewertung (BfR), Deutsche Forschungsgemeinschaft (DFG), the Else Kröner Fresenius Foundation, Gemeinsamer Bundesausschuss (G-BA), the German Academic Exchange Service, the Hertie Foundation, the Interdisciplinary Center for Clinical Studies (IZKF) Muenster, German Foundation Neurology, Alexion, Almirall, Amicus Therapeutics Germany, Biogen, Diamed, Fresenius Medical Care, Genzyme, HERZ Burgdorf, Merck Serono, Novartis, ONO Pharma, Roche, and Teva. O. Aktas has received personal fees from Alexion, Bayer Healthcare, Biogen, Celgene, Merck Serono, MedImmune, Novartis, Roche, Teva, and Zambon, outside of the submitted work. A. Berthele receives funding from the Innovationsausschuss of the German Federal Joint Committee (G-BA; project NUTSEN, grant 01VSF23040) and from the German Federal Ministry of Education and Research (BMBF; project MIDIA-Hub, grant 01ZZ2102B); has received consulting and/or speaker fees from Alexion, Argenx, Biogen, Horizon/Amgen, Merck, Novartis, Roche, and Sandoz/Hexal; and his institution has received compensation for clinical trials from Alexion, Biogen, Merck, Novartis, Roche, and Sanofi Genzyme. I. Ayzenberg received consulting and/or speaker fees and travel support from Roche, Alexion, Sanofi Genzyme, BMS, Horizon, and Merck, and received research support from Chugai, Diamed and Roche, none related to this manuscript. Go to Neurology.org/N for full disclosures.

Study Funding

The authors report no targeted funding.

Authors

Affiliations & Disclosures

From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Served on a scientific advisory board and received travel compensation and speaker honoraria - Roche (2) Served on a scientific advisory board and received travel compensation and speaker honoraria - Alexion (3) Served on a scientific advisory board and received travel compensation and speaker honoraria - Horizon/Amgen
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) speaker honoraria - Bayer (2) speaker honoraria - Roche (3) speaker honoraria - Alexion (4) speaker honoraria - Amgen
Research Support:
1.
(1) Commercial - Novartis: Research Grant (2) Commercial - Roche: Research Grant (3) Academic - Stiftung Charité: Research Grant (4) Academic - Fritz Thyssen Stiftung: Conference grant (5) Academic - Head Genuit Stiftung: Conference grant
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Gero Lindenblatt, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
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Legal Proceedings:
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Katinka Fischer, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
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NONE
Research Support:
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NONE
Stock, Stock Options & Royalties:
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Legal Proceedings:
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) received speaker honoraria - Alexion, AMGEN, Bayer Healthcare, Biogen, BMS, Celgene, Hexal, Horizon, Mylan, Merck, Neuraxpharm, Novartis, Roche, Sanofi-Aventis, Stada, Teva, Viatris (2) received funding fo travel - Alexion, AMGEN, Biogen, Celgene, Hexal, Horizon, Mylan, Merck, Novartis, Sanofi-Aventis, Teva, Viatris (3) served as a consultant - Alexion, AMGEN, Biogen, Celgene, Hexal, Horizon, Mylan, Merck, Novartis, Roche, Sanofi-Aventis, Viatris
Research Support:
1.
(1) Commercial entities - Merck (350000€): prospective influenca vaccine study (2) Commercial entities - Novartis (150000€): prospective biomarker study (3) Commercial entities - BMS (150000€): prospective biomarker study (4) Commercial entities - Teva (30000€): phagocytosis study Part 1 (5) Commercial entities - Teva (10000€): phagocytosis study Part 2
Stock, Stock Options & Royalties:
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Legal Proceedings:
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Jelena Skuljec, PhD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
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NONE
Research Support:
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Stock, Stock Options & Royalties:
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Legal Proceedings:
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Lisa Revie, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
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NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
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Legal Proceedings:
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Katrin Giglhuber, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) received funding for travel - UCB (2) received funding for travel - Viatris
Research Support:
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NONE
Stock, Stock Options & Royalties:
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Legal Proceedings:
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
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NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
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Legal Proceedings:
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Michael Karenfort, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
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NONE
Legal Proceedings:
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Speaker's bureau or travel support - Roche, Novartis, Teva, Merck, BMS, Hexal, Almirall, Biogen, Viatris,Alexion, Horizon, (2) Consultant - Merck, Roche, BMS, Novartis, Teva
Research Support:
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NONE
Stock, Stock Options & Royalties:
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NONE
Legal Proceedings:
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Research support - Biogen, Teva, Alexion, Horizon, Novartis, Merck, Sandoz, Roche (2) Personal compensation - Biogen, Teva, Alexion, Horizon, Novartis, Merck, Sandoz, Roche
Research Support:
1.
(1) Pharma - Alexion, Biogen, Teva, Merck, Horizon, Sanofi, Shire, Roche, Novartis: personal compensation, research grants (2) public - DFG: research grants (3) public - BMBF: research grants (4) public - EU Horizon: research grants
Stock, Stock Options & Royalties:
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Legal Proceedings:
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Judith Bellmann-Strobl, MD https://orcid.org/0000-0003-2615-1643
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Served on a scientific advisory board - Alexion (2) Served on a scientific advisory board - Roche (3) Served on a scientific advisory board - Merck (4) Received funding for travel or received speaker honoraria - Alexion (5) Received funding for travel or received speaker honoraria - Bayer (6) Received funding for travel or received speaker honoraria - Horizon/Amgen (7) Received funding for travel or received speaker honoraria - Novartis (8) Received funding for travel or received speaker honoraria - sanofi-aventis/Genzyme
Research Support:
1.
(1) Commercial - Alexion: NMOSD Research (2) Commercial - Bayer AG: Post COVID Research (3) Governmental - BMBF: PAIS Research (4) Foundation - NEMOS e.V.: Patient advocacy (5) Foundation - NEMOS e.V.: NMOSD Research (6) Foundation - Charité Foundation: Post COVID Research (7) Commercial - Horizon/AMGEN: Post COVID Research
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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Carolin Otto, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
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Legal Proceedings:
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) received speaker honoraria - Novartis (2) received speaker honoraria - Virion Serion (3) Academic editor - PLOS One (4) Received Publishing Royalties - Elsevier
Research Support:
1.
(1) Governmental - European Union (821283-2): Research Grant (2) Foundation - Guthy-Jackson Charitable Foundation: Research Grant (3) Foundation - Arthur Arnstein Foundation: Research Grant (4) Commercial - Novartis: Research Grant (5) Commercial - Merck Serono: Research Grant (6) Academic - Stiftung Charité: Research Grant
Stock, Stock Options & Royalties:
1.
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Legal Proceedings:
1.
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Consultancy and Speaker - Roche (2) Consultancy and Speaker - Novartis (3) Consultancy and Speaker - Sanofi (4) Consultancy and Speaker - Teva (5) Consultancy and Speaker - Almirall (6) Speaker - Hexal (7) Consultancy and Speaker - Viatris (8) Consultancy and Speaker - BMS (9) Consultancy and Speaker - Merck
Research Support:
1.
(1) Research Support - Teva: Support of research project (2) Research Support - BMS: Support of research project (3) Research Support - Novartis: Support of research project (4) Research Support - Roche: Support of research project
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
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Alexander Emmer, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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Veit Rothhammer, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Served on a Scientific Advisory Board or received Speaker Honoraria - Alexion (2) Served on a Scientific Advisory Board or received Speaker Honoraria - Merck (3) Served on a Scientific Advisory Board or received Speaker Honoraria - Novartis (4) Served on a Scientific Advisory Board or received Speaker Honoraria - Roche (5) Served on a Scientific Advisory Board or received Speaker Honoraria - Teva (6) Served on a Scientific Advisory Board or received Speaker Honoraria - Sanofi-Genzyme (7) Served on a Scientific Advisory Board or received Speaker Honoraria - Biogen (8) Served on a Scientific Advisory Board or received Speaker Honoraria - Bristol Myer Squibb (9) Served on a Scientific Advisory Board or received Speaker Honoraria - Pfizer
Research Support:
1.
(1) ERC - European Research council (851693): no industry relationship (2) DFG - German Research Foundation: no industry relationship
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
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Florian T. Nickel, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Served on a scientific advisory board or data safety monitoring board - Alexion (2) Served on a scientific advisory board or data safety monitoring board - Argenx (3) Served on a scientific advisory board or data safety monitoring board - Janssen (4) Served on a scientific advisory board or data safety monitoring board - Merck (5) Served on a scientific advisory board or data safety monitoring board - Hexal
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Klemens Angstwurm, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) funding for travel - Alexion, Bayer, BiogenIdec, MerckSerono, Novartis, Teva 2009-2014 (2) speaker honoraria - Biogen, TEVA
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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Ralf Linker, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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Sarah A. Laurent, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Institutional honoraria for consulting or lecturing - Novartis (2) Institutional honoraria for consulting or lecturing - Biogen (3) Institutional honoraria for consulting or lecturing - Roche (4) Institutional honoraria for consulting or lecturing - Alexion (5) Institutional honoraria for consulting or lecturing - Janssen (6) Institutional honoraria for consulting or lecturing - Sanofi Genzyme (7) Institutional honoraria for consulting or lecturing - Merck (8) Institutional honoraria for consulting or lecturing - Bayer (9) Institutional honoraria for consulting or lecturing - Hexal
Research Support:
1.
(1) research project - Novartis: IIT in MS (2) research project - Biogen: IIT in MS/PML (3) research project - Gemeinsamer Bundesausschuss : IIT in MS (4) research project - German Research Foundation (501362249): PML
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
(1) expert testimony, topic JC virus serology for Wuesthoff +Wuesthoff sowie Bristows LLP in 2023
Sven Jarius, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Mirjam Korporal-Kuhnke, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Speaker Honoraria - Novartis (2) Speaker Honoraria - BMS (3) Speaker Honoraria - Merck
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Brigitte Wildemann, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Honoraria and Travel Compensation - Alexion (2) Honoraria and Travel Compensation - INSTAND (3) Honoraria and Travel Compensation - Merck (4) Honoraria and Travel Compensation - Novartis (5) Honoraria and Travel Compensation - Roche
Research Support:
1.
(1) Financial support - German MInistry of Education and Research: competence network MD (2) Financial support - Deutsche Forschungsgemeinschaft: FOR2289 (3) Financial support - Dietmar Hopp Foundation: NMOSD and MOGAD (4) Financial support - Klaus Tschira Foundation: MS (5) Financial support - Merck: NMOSD and MOGAD (6) Financial support - Novartis: MS (7) Financial support - Roche: NMOSD and MOGAD
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Speaker honoraria - Mylan (2) Speaker honoraria - Novartis
Research Support:
1.
(1) Commercial - Novartis: research funding; outside submitted work
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Maria Seipelt, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) travel grants - Alexion, Novartis and Sanofi Genzyme (2) honoraria for active participation in advisory boards and speaker/writing honoraria - Alexion, AMGEN, Bristol Meyers Squibb, Kassenärztliche Vereinigung Hessen, Landesärztekammer Hessen, Merck, Novartis, RG Gesellschaft für Information und Organisation mbH, Roche, Sanofi Genzyme, TEVA
Research Support:
1.
(1) Society - Deutsche Forschungsgemeinschaft (DFG) (511312822): competitive grant (2) Academic - Fachbereich Medizin der Goethe-Universität Frankfurt: competitive grant (3) Foundation - Heinrich und Erna Schaufler Stiftung: competitive grant (4) Commercial - GmbH: competitive grant
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Nele Retzlaff, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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Uwe K. Zettl, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Funding for travel and speaker honoraria - Almirall (2) Funding for travel and speaker honoraria - Alexion (3) Funding for travel and speaker honoraria - Bayer (4) Funding for travel and speaker honoraria - Merck (5) Funding for travel and speaker honoraria - Johnson & Johnson (6) Funding for travel and speaker honoraria - BMS (7) Funding for travel and speaker honoraria - Biogen (8) Funding for travel and speaker honoraria - Sanofi
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Honorary for consultancy and lectures - Alexion/Astra Zeneca (2) Honorary for lectures - Allmiral (3) Honorary for consultancy and lectures - Amicus (4) Honorary for lectures - Biogen (5) Honorary for consultancy and lectures - Horizon/AMGEN (6) Honorary for consultancy and lectures - Merck (7) Honorary for consultancy and lectures - Novartis (8) Honorary for consultancy and lectures - Roche (9) Honorary for consultancy - Sandoz (10) Honorary for consultancy and lectures - Sanofi (11) Honorary for lectures - TEVA
Research Support:
1.
(1) Commerical - Merck: Imaging in MS (2) Commercial - Roche: Imaging in MS (3) Commerical - Amicus: Biomarker in Fabry Disease (4) Governmental - Austrian Science Funds: Biomarker in ALD (5) Governmental - Austrian Science Funds: Imaging in MS
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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Markus C. Kowarik, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Speaker honoraria - Merck, Sanofi-Genzyme, Novartis, Biogen, Janssen, Alexion, Celgene / Bristol-Myers Squibb and Roche (2) Scientific advisory board - Merck, Sanofi-Genzyme, Novartis, Biogen, Janssen, Alexion, Celgene / Bristol-Myers Squibb and Roche (3) Funding for travel - Merck, Sanofi-Genzyme, Novartis, Janssen, Bristol-Myers Squibb and Roche (4) Patent pending - Eberhard Karls Universität Tübingen
Research Support:
1.
(1) DFG - Tumor specific cerebrospinal fluid (CSF) B cell response in cancer patients with CNS manifestation (KO 4367/5-1): see entity name (2) IIT Roche - Immunoglobulin (Ig) repertoire analysis in multiple sclerosis patients treated with ocrelizumab (n.a.): see entity name (3) IIT Novartis - Immunoglobulin (Ig) repertoire analysis in multiple sclerosis patients treated with ofatumumab (n.a.): see entity name (4) IIT Janssen - B cell repertoire analysis in ponesimod treated multiple sclerosis patients (n.a.): see entity name (5) IIT Celgene / BMS - Immunoglobulin (Ig) repertoire analysis in multiple sclerosis patients treated with ozanimod (n.a.): see entity name
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) advisory board - Roche (2) advisory board - Sobi (3) advisory board - Alexion (4) speaker honoraria - Alexion (5) speaker honoraria - Roche (6) advisory board - Argenx
Research Support:
1.
(1) Grant support - German Research Foundation: Translational studies (2) Research support - Hermann and Lilly Schilling Foundation: Translational studies (3) Grant support - German Ministry of Health: Translational and clinical studies
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
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Corinna Trebst, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) speaker honoraria - Alexion Pharma Germany GmbH
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Makbule Senel, MD
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) consulting and/or speaker honoraria - Alexion (2) consulting and/or speaker honoraria - Bayer (3) consulting and/or speaker honoraria - Biogen (4) consulting and/or speaker honoraria - Bristol-Myers-Squibb/Celgene (5) conconsulting and/or speaker honoraria - Janssen (6) consulting and/or speaker honoraria - Merck (7) consulting and/or speaker honoraria - Horizon/Amgen (8) consulting and/or speaker honoraria - Roche (9) consulting and/or speaker honoraria - Sanofi Genzyme
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) speaker honorarium - Biogen (2) speaker honorarium - BMS (3) speaker honorarium - Novartis (4) speaker honorarium - Roche (5) speaker honorarium - Janssen (6) speaker honorarium - Sanofi (7) speaker honorarium - Eisai (8) speaker honorarium - TEVA (9) consulting honorarium - Kyverna
Research Support:
1.
(1) Commercial - Biogen: Fumarate Metabolom research (2) Commercial - Novartis: MRI research on fiber tract pathology (3) Commercial - Novartis: Efficacy of antiCD20 trreatment (4) State - GERMAN RESEARCH COMMUNITY: neuronal stem cells and fatty acids
Stock, Stock Options & Royalties:
1.
(1) Stock ownership - Novartis: bought myself (2) Stock ownership - Roche: bought myself (3) Stock ownership - Merck: bought myself
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Served on a scientific advisory board - Alexion, Biogen, Bristol-Myers Squibb, Genzyme, Hexal, Horizon, Janssen, Merck Serono, Novartis, Roche, Sandoz, Sanofi, Viatris (2) Received funding for travel or received speaker honoraria - Argenx, Bayer, Biogen, Bristol-Myers Squibb, Genzyme, Grifols, Merck Serono, Novartis, Roche, Santhera, Teva. (3) Rearch support - German Research Foundation, the IZKF Münster, IMF Münster, Biogen, Novartis and Merck Serono.
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Christoph Kleinschnitz, MD https://orcid.org/0000-0002-1650-8875
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Sven Meuth receives honoraria for lecturing, and travel expenses for attending meetings from Academy 2, Argenx, Alexion, Almirall, Amicus Therapeutics Germany, Bayer Health Care, Biogen, BioNtech, BMS, Celgene, Datamed, Demecan, Desitin, Diamed, Diaplan, DIU Dresden, DPmed, Gen Medicine and Healthcare products, Genzyme, Hexal AG, Impulze GmbH, Janssen Cilag, KW Medipoint, MedDay Pharmaceuticals, Merck Serono, Neuropoint, Novartis, Novo Nordisk, ONO Pharma, Oxford PharmaGenesis, Roche, Sanofi-Aventis, Springer Medizin Verlag, Chugai Pharma, QuintilesIMS,Teva, Wings for Life international and Xcenda - Sven Meuth receives honoraria for lecturing, and travel expenses for attending meetings from Academy 2, Argenx, Alexion, Almirall, Amicus Therapeutics Germany, Bayer Health Care, Biogen, BioNtech, BMS, Celgene, Datamed, Demecan, Desitin, Diamed, Diaplan, DIU Dresden, DPmed, Gen Medicine and Healthcare products, Genzyme, Hexal AG, Impulze GmbH, Janssen Cilag, KW Medipoint, MedDay Pharmaceuticals, Merck Serono, Neuropoint, Novartis, Novo Nordisk, ONO Pharma, Oxford PharmaGenesis, Roche, Sanofi-Aventis, Springer Medizin Verlag, Chugai Pharma, QuintilesIMS,Teva, Wings for Life international and Xcenda
Research Support:
1.
NONE
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Speaker honoraria, scientific advisory board, travel funding - Alexion (2) Speaker honoraria, scientific advisory board, travel funding - Almirall (3) Speaker honoraria, scientific advisory board, travel funding - Horizon (4) Scientific advisory board - Merck (5) Speaker honoraria, scientific advisory board, travel funding - Novartis (6) Speaker honoraria, scientific advisory board, travel funding - Roche (7) Speaker honoraria, scientific advisory board, travel funding - Amgen (8) Speaker honoraria, scientific advisory board, travel funding - Mitsubishi Tanake Pharma Cooperation
Research Support:
1.
(1) Academic entity - German Research Foundation (GRK 2578): Research Training Group (2) Academic entity - German Ministry of Education and Research (KKNMS-NationNMO): Competence Network MS (3) Academic entity - German G-BA Innofonds (NUTSEN FKZ: 01VSF23040): Real-Word Evidence Study on NMOSD therapy
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Served as a consultant - Alexion (2) Served as a consultant - Argenx (3) Served as a consultant - Horizon/Amgen (4) Served as a consultant - Roche (5) received speaker honoraria - Alexion (6) received speaker honoraria - Argenx (7) received speaker honoraria - Biogen (8) received speaker honoraria - Horizon/Amgen (9) received speaker honoraria - Merck (10) received speaker honoraria - Novartis (11) received speaker honoraria - Roche (12) received speaker honoraria - Sandoz/Hexal
Research Support:
1.
(1) Governmental entity - Gemeinsamer Bundesausschuss (#01VSF23040): pharmacoeconomic evaluation of NMOSD treatments (2) Governmental entity - German Federal Ministry of Education and Research (#01ZZ2102B): multiple sclerosis
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Scientific advisory board - Roche, Alexion, Horizon, Sanofi (2) Speaker Honoraria - Roche, Alexion, Horizon, Sanofi (3) Travel funding - BMS, Alexion
Research Support:
1.
(1) Commercial - Diamed, Roche, Alexion (NA): Study grants non-attributed to the manuscript
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
for the German Neuromyelitis Optica Study Group (NEMOS)
From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.

Notes

Correspondence Dr. Ringelstein [email protected] or Dr. Ayzenberg [email protected]
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
The Article Processing Charge was funded by Heinrich-Heine-University Düsseldorf, Germany.
Coinvestigators are listed in the supplemental digital content available at Neurology.org/N.
Submitted and externally peer reviewed. The handling editor was Deputy Editor Olga Ciccarelli, MD, PhD, FRCP.
*
These authors contributed equally to this work.
These authors are the corresponding authors.

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