Skip to main content
AAN.com
Editorial
January 29, 2025

Cholesterol Variability and Dementia Risk
Finding Meaning in the Ups and Downs

This article has related content.
VIEW RELATED CONTENT
February 25, 2025 issue
104 (4)

Get full access to this article

View all available purchase options and get full access to this article.

References

1.
Livingston G, Huntley J, Liu KY, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404(10452):572-628.
2.
Zhou Z, Moran C, Murray AM, et al. Association of year-to-year lipid variability with risk of cognitive decline and dementia in community-dwelling older adults. Neurology. 2025;104(4):e210247.
3.
Smit RAJ, Trompet S, Sabayan B, et al. Higher visit-to-visit low-density lipoprotein cholesterol variability is associated with lower cognitive performance, lower cerebral blood flow, and greater white matter hyperintensity load in older subjects. Circulation. 2016;134(3):212-221.
4.
Moser ED, Manemann SM, Larson NB, et al. Association between fluctuations in blood lipid levels over time with incident Alzheimer disease and Alzheimer disease–related dementias. Neurology. 2023;101(11):e1127-e1136.
5.
Li S, Hou L, Zhu S, et al. Lipid variability and risk of cardiovascular diseases and all-cause mortality: a systematic review and meta-analysis of cohort studies. Nutrients. 2022;14(12):2450.
6.
Song R, Hu M, Qin X, et al. The roles of lipid metabolism in the pathogenesis of chronic diseases in the elderly. Nutrients. 2023;15(15):3433.
7.
Jia J, Ning Y, Chen M, et al. Biomarker changes during 20 years preceding Alzheimer's disease. N Engl J Med. 2024;390(8):712-722.
8.
Bernstein A, Rogers KM, Possin KL, et al. Dementia assessment and management in primary care settings: a survey of current provider practices in the United States. BMC Health Serv Res. 2019;19(1):919.
9.
Gong J, Harris K, Peters SAE, Woodward M. Serum lipid traits and the risk of dementia: a cohort study of 254,575 women and 214,891 men in the UK Biobank. eClinicalMedicine. 2022;54:101695.
10.
Thorpe JM, Thorpe CT, Kennelty KA, Pandhi N. Patterns of perceived barriers to medical care in older adults: a latent class analysis. BMC Health Serv Res. 2011;11(1):181.
11.
Adkins-Jackson PB, George KM, Besser LM, et al. The structural and social determinants of Alzheimer's disease related dementias. Alzheimers Dement. 2023;19(7):3171-3185.

Information & Authors

Information

Published In

Neurology®
Volume 104Number 4February 25, 2025
PubMed: 39879574

Publication History

Received: November 1, 2024
Accepted: December 13, 2024
Published online: January 29, 2025
Published in print: February 25, 2025

Permissions

Request permissions for this article.

Disclosure

The authors report no relevant disclosures. Go to Neurology.org/N for full disclosures.

Study Funding

This work was supported by NIH/National Institute on Aging grants RF1AGO69259 and T32AG049663-06A1.

Authors

Affiliations & Disclosures

Department of Epidemiology and Biostatistics, University of California, San Francisco;
Disclosure
Financial Disclosure:
1.
NONE
Research Support:
1.
(1) Governmental entities - NIH/NIA (T32AG049663): Translational Epidemiology - Training for Research on Aging and Chronic disease (2) Governmental entities - NIH/NIA (1RF1AG069259-01): Statin Treatment and Incident Alzheimer's Disease and Related Dementias in a Large, Multi-ethnic Health Plan (3) Governmental entities - NIH/NIA (F31AG085965-01): Evaluating routine clinical decisions in providing primary care for people living with Alzheimer's Disease or Alzheimer's Related Disorders: using electronic health records to provide timely evidence
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Department of Pediatrics and Medicine, University of California, San Francisco; and
Disclosure
Financial Disclosure:
1.
Relevant Clinical Procedures: (1) spends 6.25%% effort for UCSF Lipid Clinic- Statin prescription
Research Support:
1.
(1) Governmental entity - NIH (1RF1AG069259): Statin effect on dementia
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE
Kaiser Permanente Division of Research, Pleasanton, CA.
Disclosure
Financial Disclosure:
1.
Personal Compensation: (1) Personal compensation-- salaried employee - Kaiser Permanente Division of Research
Research Support:
1.
(1) Governmental - NIMH (R01 MH121542): genome wide association study of Major depressive disorder treated with electroconvulsive therapy (2) Governmental - NIA (R01 AG069259): historical cohort study of association of statin treatment with risk of dementia (3) Foundation - Michael J Fox Foundation (18689.01): historical cohort study of bipolar disorder and risk of Parkinson's disease (4) Governmental - NIA (R01 AG057869): This project integrates evidence on the association between vascular risk factors and cognitive outcomes from observational studies in order to create a simulation platform to mirror proposed RCTs. (5) Governmental - NINR (R01NR017431): Study of cognitive function, quality of life, and physical disability on a multi-ethnic sample of ∼3000 individuals with multiple sclerosis (6) Governmental - NIA (RF1AG059872-01S1): Investigation of inverse association between cancer and Alzheimer's disease 2024-12-11
Stock, Stock Options & Royalties:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Correspondence Ms. Ferguson [email protected]

Metrics & Citations

Metrics

Citation information is sourced from Crossref Cited-by service.

Citations

Download Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.

Cited By

View Options

Login options

Check if you have access through your login credentials or your institution to get full access on this article.

Personal login Institutional Login
Purchase Options

The neurology.org payment platform is currently offline. Our technical team is working as quickly as possible to restore service.

If you need immediate support or to place an order, please call or email customer service:

  • 1-800-638-3030 for U.S. customers - 8:30 - 7 pm ET (M-F)
  • 1-301-223-2300 for customers outside the U.S. - 8:30 - 7 pm ET (M-F)
  • [email protected]

We appreciate your patience during this time and apologize for any inconvenience.

View options

PDF and All Supplements

Download PDF and Supplementary Material

Full Text

View Full Text

Full Text HTML

View Full Text HTML

Figures

Tables

Media

Share

Share

Share article link

Share