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July 13, 2011

Weekend high-dosage prednisone
A new option for treatment of Duchenne muscular dystrophy

August 2, 2011 issue
77 (5) 416-417

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Moxley RT, Ashwal S, Pandya S, et al. Practice parameter: corticosteroid treatment of Duchenne dystrophy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2005;64:13–20.
Balaban B, Matthews DJ, Clayton GH, Carry T. Corticosteroid treatment and functional improvement in Duchenne muscular dystrophy: long-term effect. Am J Phys Med Rehabil 2005;84:843–850.
Biggar WD, Harris VA, Eliasoph L, Alman B. Long-term benefits of deflazacort treatment for boys with Duchenne muscular dystrophy in their second decade. Neuromuscul Disord 2006;16:249–255.
King WM, Ruttencutter R, Nagaraja HN, et al. Orthopedic outcomes of long-term daily corticosteroid treatment in Duchenne muscular dystrophy. Neurology 2007;68:1607–1613.
Houde S, Filiatrault M, Fournier A, et al. Deflazacort use in Duchenne muscular dystrophy: an 8-year follow-up. Pediatr Neurol 2008;38:200–206.
Moxley RT, Pandya S, Ciafaloni E, Fox DJ, Campbell K. Change in natural history of Duchenne muscular dystrophy with long-term corticosteroid treatment: implications for management. J Child Neurol 2010;25:1116–1129.
Escolar DM, Hache LP, Clemens PA, et al. Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy. Neurology 2011;77:444–452.
Connolly AM, Schierbecker J, Renna R, Florence J. High dose weekly oral prednisone improves strength in boys with Duchenne muscular dystrophy. Neuromuscul Disord 2002;12:917–925.

Information & Authors


Published In

Volume 77Number 5August 2, 2011
Pages: 416-417
PubMed: 21753162

Publication History

Published online: July 13, 2011
Published in print: August 2, 2011


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Dr. Moxley receives research support from the NIH (NCRR/NIAMS) and NINDS, which supports the Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center; has served on scientific advisory boards for the NIH and the CDC; and has served as a consultant for Insmed, Inc. Dr. Pandya serves as a consultant for Acceleron Pharma and Shire plc and receives research support from the NIH and the CDC.


Affiliations & Disclosures

Richard T. Moxley, III, MD
From the Department of Neurology, University of Rochester Medical Center, Rochester, NY.
Shree Pandya, PT, DPT, MS
From the Department of Neurology, University of Rochester Medical Center, Rochester, NY.


Address correspondence and reprint requests to Dr. Richard T. Moxley III, Department of Neurology, Box 673, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642 [email protected]

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