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July 25, 2012

Statins do not cause intracerebral hemorrhage

September 11, 2012 issue
79 (11) 1076-1077

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REFERENCES

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Nardi K, Engelter S, Strbian D, et al., on behalf of the Lipid Profile in Thrombolysis Study Group. Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemia. Neurology 2012;79:1101–1108.
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Hackam DG, Wu F, Li P, et al. Statins and renovascular disease in the elderly: a population-based cohort study. Eur Heart J 2011;32:598–610.
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Hackam DG, Woodward M, Newby LK, et al. Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysis. Circulation 2011;124:2233–2242.
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Goldstein LB, Amarenco P, Szarek M, et al. Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. Neurology 2008;70:2364–2370.
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Spence JD, Hackam DG. Response to letter by Hadjiev et al. Stroke 2011;42:e42.
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Hachinski V, Graffagnino C, Beaudry M, et al. Lipids and stroke: a paradox resolved. Arch Neurol 1996;53:303–308.
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Amarenco P, Labreuche J. Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol 2009;8:453–463.
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Sillesen H, Amarenco P, Hennerici MG, et al. Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke 2008;39:3297–3302.
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Chimowitz MI, Weiss DG, Cohen SL, Starling MR, Hobson RW. Cardiac prognosis of patients with carotid stenosis and no history of coronary artery disease: Veterans Affairs Cooperative Study Group 167. Stroke 1994;25:759–765.
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Information & Authors

Information

Published In

Neurology®
Volume 79Number 11September 11, 2012
Pages: 1076-1077
PubMed: 22843275

Publication History

Published online: July 25, 2012
Published in print: September 11, 2012

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Disclosure

The author reports no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

Authors

Affiliations & Disclosures

J. David Spence, MD, FRCPC, FAHA
From the Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
I have received lecture fees from Merck, Novartis, Boehringer-Ingelheim
Editorial Boards:
1.
I was Assistant Editor of Stroke from 2000 to 2010, and am a member of the editorial boards of Hypertension and of Arteriosclerosis, Thrombosis & Vascular Biology.
Patents:
1.
NONE
Publishing Royalties:
1.
How to prevent your stroke. Vanderbilt University Press 2006; Stroke Prevention, Treatment and Rehabilitation. McGraw-Hill Medical, New York, 2012
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Consultant to Boehringer-Ingelheim; not related to this paper.
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
I have an interest in www.vascularis.com
Clinical Procedures or Imaging Studies:
1.
Yes, I use intensive medical therapy based on carotid plaque measurements in my practice
Research Support, Commercial Entities:
1.
Merck provided a small grant to support a summer student in my laboratory in 2010
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
I have received grants from the Heart & Stroke Foundation of Canada (Ontario) and the Canadian Institutes for Health Research
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Correspondence & reprint requests to Dr. Spence: [email protected]

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Cited By
  1. Low LDL-C/HDL-C Ratio is Associated with Poor Clinical Outcome After Intracerebral Hemorrhage: A Retrospective Analysis of Multicenter, Prospective Cohort Data in China, Neurocritical Care, 41, 1, (29-37), (2023).https://doi.org/10.1007/s12028-023-01905-z
    Crossref
  2. Intracerebral Hemorrhage in SPARCL, Journal of the American College of Cardiology, 76, 7, (885-886), (2020).https://doi.org/10.1016/j.jacc.2020.05.080
    Crossref
  3. The need for clinical judgement in the application of evidence-based medicine, BMJ Evidence-Based Medicine, 25, 5, (172-177), (2019).https://doi.org/10.1136/bmjebm-2019-111300
    Crossref
  4. Cardiovascular Risk Beyond Low-Density Lipoprotein Cholesterol, Journal of the American College of Cardiology, 71, 6, (633-635), (2018).https://doi.org/10.1016/j.jacc.2017.12.040
    Crossref
  5. Recent advances in preventing stroke recurrence, F1000Research, 6, (1017), (2017).https://doi.org/10.12688/f1000research.11597.1
    Crossref
  6. Utilization of Statins Beyond the Initial Period After Stroke and 1‐Year Risk of Recurrent Stroke, Journal of the American Heart Association, 6, 8, (2017).https://doi.org/10.1161/JAHA.117.005658
    Crossref
  7. Overcoming Challenges With Statin Therapy, Journal of the American Heart Association, 5, 1, (2016).https://doi.org/10.1161/JAHA.115.002497
    Crossref
  8. Secondary Prevention After Symptomatic Large Artery Extracranial Disease, Ischemic Stroke Therapeutics, (147-160), (2016).https://doi.org/10.1007/978-3-319-17750-2_14
    Crossref
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