Skip to main content
AAN.com

Abstract

Objective:

The long-chain ω-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are potential candidates for interventions to delay Alzheimer disease (AD), but evidence from clinical studies is mixed. We aimed at determining whether plasma levels of EPA or DHA predict atrophy of medial temporal lobe (MTL) gray matter regions in older subjects.

Methods:

A total of 281 community dwellers from the Three-City Study, aged 65 years or older, had plasma fatty acid measurements at baseline and underwent MRI examinations at baseline and at 4 years. We studied the association between plasma EPA and DHA and MTL gray matter volume change at 4 years.

Results:

Higher plasma EPA, but not DHA, was associated with lower gray matter atrophy of the right hippocampal/parahippocampal area and of the right amygdala (p < 0.05, familywise error corrected). Based on a mean right amygdala volume loss of 6.0 mm3/y (0.6%), a 1 SD higher plasma EPA (+0.64% of total plasma fatty acids) at baseline was related to a 1.3 mm3 smaller gray matter loss per year in the right amygdala. Higher atrophy of the right amygdala was associated with greater 4-year decline in semantic memory performances and more depressive symptoms.

Conclusion:

The amygdala, which develops neuropathology in the early stage of AD and is involved in the pathogenesis of depression, may be an important brain structure involved in the association between EPA and cognitive decline and depressive symptoms.

Get full access to this article

View all available purchase options and get full access to this article.

Supplementary Material

File (e-discussion.docx)
File (e-methods.docx)
File (e-results.docx)
File (figure_e-1.docx)
File (table_e-1.docx)
File (table_e-2.docx)

Study Funding

The 3C study is conducted under a partnership agreement between Sanofi-Aventis and the Institut National de la Santé et de la Recherche Médicale (INSERM) and the Institut de Santé Publique et Développement of the Victor Segalen Bordeaux 2 University. The Fondation pour la Recherche Médicale (FRM) funded the preparation and initiation of the study. The 3C study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés (CNAMTS), Direction Générale de la Santé (DGS), Mutuelle Générale de l'Education Nationale (MGEN), Institut de la Longévité, Regional Councils of Aquitaine and Bourgogne, Fondation de France, and Ministry of Research–INSERM Programme “Cohortes et collections de données biologiques.” Fatty acid analyses performed by E. Peuchant were sponsored by the Conseil Régional d'Aquitaine. Dr Samieri was on a grant from the Ligue Européenne contre la Maladie d'Alzheimer (LECMA). Dr Proust-Lima received research support from ANR grant PRSP00601. The Canada Research Chairs, CFI, FRSQ, and CIHR, financed S.C.C.'s contribution to this paper. The study sponsors funded the preparation and initiation of the 3C study, as well as the data collection. They did not interfere in analysis and interpretation of the data, in writing the report, or in the decision to submit the paper for publication.

REFERENCES

1.
Fotuhi M, Mohassel P, Yaffe K. Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Nat Clin Pract Neurol 2009; 5: 140– 152.
2.
Cunnane SC, Plourde M, Pifferi F, Begin M, Feart C, Barberger-Gateau P. Fish, docosahexaenoic acid and Alzheimer's disease. Prog Lipid Res 2009; 48: 239– 256.
3.
Yurko-Mauro K, McCarthy D, Rom D, et al. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement 2010; 6: 456– 464.
4.
Dangour AD, Allen E, Elbourne D, et al. Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. Am J Clin Nutr 2010; 91: 1725– 1732.
5.
Quinn JF, Raman R, Thomas RG, et al. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA 2010; 304: 1903– 1911.
6.
Tan ZS, Harris WS, Beiser AS, et al. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology 2012; 78: 658– 664.
7.
Three-City Study Group. Vascular Risk factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population. Neuroepidemiology 2003; 22: 316– 325.
8.
The FIL Methods Group. SPM8 Manual. London, UK, 2010. Available at: http://www.fil.ion.ucl.ac.uk/spm/doc/manual.pdf. Accessed June 2012.
9.
Lemaitre H, Crivello F, Dufouil C, et al. No epsilon4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects. Neuroimage 2005; 24: 1205– 1213.
10.
Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002; 15: 273– 289.
11.
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189– 198.
12.
Isaacs B, Kennie AT. The Set test as an aid to the detection of dementia in old people. Br J Psychiatry 1973; 123: 467– 470.
13.
Amieva H, Le Goff M, Millet X, et al. Prodromal Alzheimer's disease: successive emergence of the clinical symptoms. Ann Neurol 2008; 64: 492– 498.
14.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV. Washington, DC: American Psychiatric Association; 1994.
15.
Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977; 1: 385– 401.
16.
Berkman LF, Berkman CS, Kasl S, et al. Depressive symptoms in relation to physical health and functioning in the elderly. Am J Epidemiol 1986; 124: 372– 388.
17.
Fuhrer R, Rouillon F. La Version Française de l'Échelle CES-D (Center for Epidemiologic Studies–Depression Scale): description et traduction de l'échelle d'auto-évaluation. Psychiatr Psychobiol 1989; 4: 163– 166.
18.
Samieri C, Feart C, Letenneur L, et al. Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk. Am J Clin Nutr 2008; 88: 714– 21.
19.
Proust-Lima C, Dartigues JF, Jacqmin-Gadda H. Misuse of the linear mixed model when evaluating risk factors of cognitive decline. Am J Epidemiol 2011; 174: 1077– 1088.
20.
Laird NM, Ware JH. Random-effects models for longitudinal data. Biometrics 1982; 38: 963– 974.
21.
Proust C, Jacqmin-Gadda H, Taylor JM, Ganiayre J, Commenges D. A nonlinear model with latent process for cognitive evolution using multivariate longitudinal data. Biometrics 2006; 62: 1014– 1024.
22.
Virtanen JK, Siscovick DS, Longstreth WT, Kuller LH, Mozaffarian D. Fish consumption and risk of subclinical brain abnormalities on MRI in older adults. Neurology 2008; 71: 439– 446.
23.
Bowman GL, Silbert LC, Howieson D, et al. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology 2012; 78: 241– 249.
24.
Conklin SM, Gianaros PJ, Brown SM, et al. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neurosci Lett 2007; 421: 209– 212.
25.
Samieri C, Feart C, Proust-Lima C, et al. Omega-3 fatty acids and cognitive decline: modulation by ApoEepsilon4 allele and depression. Neurobiol Aging 2011; 32: 2317.e13– e22.
26.
Feart C, Peuchant E, Letenneur L, et al. Plasma eicosapentaenoic acid is inversely associated with severity of depressive symptomatology in the elderly: data from the Bordeaux sample of the Three-City Study. Am J Clin Nutr 2008; 87: 1156– 1162.
27.
Parker G, Gibson NA, Brotchie H, Heruc G, Rees AM, Hadzi-Pavlovic D. Omega-3 fatty acids and mood disorders. Am J Psychiatry 2006; 163: 969– 978.
28.
Martins JG. EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr 2009; 28: 525– 542.
29.
Stoub TR, Bulgakova M, Leurgans S, et al. MRI predictors of risk of incident Alzheimer disease: a longitudinal study. Neurology 2005; 64: 1520– 1524.
30.
den Heijer T, Geerlings MI, Hoebeek FE, Hofman A, Koudstaal PJ, Breteler MM. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people. Arch Gen Psychiatry 2006; 63: 57– 62.
31.
Horinek D, Varjassyova A, Hort J. Magnetic resonance analysis of amygdalar volume in Alzheimer's disease. Curr Opin Psychiatry 2007; 20: 273– 277.
32.
Ferreira LK, Diniz BS, Forlenza OV, Busatto GF, Zanetti MV. Neurostructural predictors of Alzheimer's disease: a meta-analysis of VBM studies. Neurobiol Aging 2011; 32: 1733– 1741.
33.
Risacher SL, Saykin AJ, West JD, Shen L, Firpi HA, McDonald BC. Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort. Curr Alzheimer Res 2009; 6: 347– 361.
34.
Murphy EA, Holland D, Donohue M, et al. Six-month atrophy in MTL structures is associated with subsequent memory decline in elderly controls. Neuroimage 2010; 53: 1310– 1317.
35.
Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature 2008; 455: 894– 902.
36.
Hamilton JP, Siemer M, Gotlib IH. Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Mol Psychiatry 2008; 13: 993– 1000.
37.
Suslow T, Konrad C, Kugel H, et al. Automatic mood-congruent amygdala responses to masked facial expressions in major depression. Biol Psychiatry 2010; 67: 155– 160.
38.
Windischberger C, Lanzenberger R, Holik A, et al. Area-specific modulation of neural activation comparing escitalopram and citalopram revealed by pharmaco-fMRI: a randomized cross-over study. Neuroimage 2010; 49: 1161– 1170.
39.
Hodson L, Skeaff CM, Fielding BA. Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 2008; 47: 348– 380.
40.
Harald K, Salomaa V, Jousilahti P, Koskinen S, Vartiainen E. Non-participation and mortality in different socioeconomic groups: the FINRISK population surveys in 1972–92. J Epidemiol Community Health 2007; 61: 449– 454.

Information & Authors

Information

Published In

Neurology®
Volume 79Number 7August 14, 2012
Pages: 642-650
PubMed: 22855869

Publication History

Received: November 17, 2011
Accepted: March 21, 2012
Published online: August 1, 2012
Published in print: August 14, 2012

Permissions

Request permissions for this article.

Disclosure

C. Samieri, P. Maillard, F. Crivello, C. Proust-Lima, E. Peuchant, and C. Helmer report no disclosures. H. Amieva received speaker honoraria from GSK, UCB, and Novartis. M. Allard reports no disclosures. J.F. Dartigues reports research grants from Ipsen and Novartis, and speaker honoraria from Ipsen, Novartis, and Merck Serono. S.C. Cunnane and B. Mazoyer report no disclosures. P. Barberger-Gateau served on a scientific advisory board for Caisse Nationale pour la Solidarit é et l'Autonomie (CNSA); has received funding for travel and speaker honoraria from Lesieur, Bausch & Lomb, Aprifel, Danone Institute, Canadian Association of Gerontology, and the Jean Mayer Human Nutrition Research Center on Aging, Tufts University; has received consultancy fees from Vifor Pharma; and receives research support from Lesieur, Danone, Agence Nationale de la Recherche, Conseil Régional d'Aquitaine, Institut Carnot LISA, and Groupe Lipides et Nutrition. Go to Neurology.org for full disclosures.

Authors

Affiliations & Disclosures

Cécilia Samieri, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Ligue Europeenne contre la Maladie d’Alzheimer (LECMA; European league against Alzheimer’s disease)
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Pauline Maillard, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Fabrice Crivello, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Cécile Proust-Lima, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Danone research;
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
INCA 2010-059, investigator, 2010-2013; ANR 2010 PRSP 00601, 2010-2013
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Evelyne Peuchant, MD, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Catherine Helmer, MD, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Helene Amieva, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Novartis, symposimum speaker, 2010; UCB pharma, meeting speaker, 2010, 2011; GSK, meeting speaker, 2010
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Michele Allard, MD, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Jean-Francois Dartigues, MD, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
Janssen cilag, member, 2007-2009
Gifts:
1.
Novartis, 2008, 800 €
Funding for Travel or Speaker Honoraria:
1.
ICAD Congress Chicago, Janssen ICAD Congress Vienna, Pfizer ICAD Congress Paris, Novartis
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Merk Serono. Safinamide Surveillance Comittee Meeting, 1000 €, 2009 2000 €, 2009 2500 €, 2010 2500 €, 2011 3000 €, 2012
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Paquid study Novartis, 40 000 €, 2008, 2009, 2010, 2011,2012 Paquid study Ipsen, 40 000 €, 2008, 2009, 2010, 2011,2012
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Stephen C. Cunnane, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
1. NUTRITION (Editorial board) 2. PROGRESS IN LIPID RESEARCH (Editorial board)
Patents:
1.
NONE
Publishing Royalties:
1.
1. Survival of the Fattest, World Scientific, 2005 2. Human brain Evolution, Wiley, 2010
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
1. Canadian Institutes of Health Research, DC0190GP (2010- 2015) 2. Natural Sciences and Engineering Research Council of Canada, 3606-2008 (2008-2013)
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
International Society for the study of fatty acids and lipids
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Bernard M. Mazoyer, MD, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Pascale Barberger-Gateau, MD, PhD
From the Equipe “Epidemiologie de la nutrition et des comportements alimentaires” (C.S., P.B.-G.), Equipe “Biostatistiques” (C.P.-L.), and Equipe “Epidémiologie et neuropsychologie du vieillissement cerebral” (C.H., H.A., J.-F.D.), Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INSERM (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; University of Bordeaux (C.S., C.P.-L., C.H., H.A., J.-F.D., P.B.-G.), ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux; CNRS (P.M.), CI-NAPS, UMR6232, Caen, France; CEA (P.M.), DSV/I2BM/CI-NAPS, Caen; University of Caen Basse-Normandie (P.M.), Caen; CNRS (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; CEA (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; University of Bordeaux (F.C., B.M.M.), GIN, UMR 5296, Bordeaux; INSERM (E.P.), INSERM U876, Bordeaux; CHU de Bordeaux (E.P.), Hôpital Saint-André, Département de Biochimie, INSERM U876, Bordeaux; Neurofunctional and Cognitive Imaging Team (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CNRS (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; University of Bordeaux (M.A.), CNRS/UB1/UB2 Unit, Bordeaux; CHU de Bordeaux (M.A.), Service de Médecine Nucléaire, CNRS/UB1/UB2 Unit, Bordeaux; and Research Center on Aging (S.C.C.), Université de Sherbrooke, Sherbrooke, Canada.
Disclosure
Scientific Advisory Boards:
1.
Caisse Nationale pour la Solidarité et l’Autonomie (CNSA): governmental agency, member of the scientific advisory board for the FORMADEP project, 2009-2010
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
1) Lesieur: travel and speaker honoraria 2) Bausch & Lomb: travel and speaker hononoraria 3) APRIFEL: travel and speaker honoraria 4) Canadian Association of Gerontology: travel 5) Jean Mayer Human Nutrition Research Center on Aging, Tufts University: travel and speaker honoraria 6) Danone Institute : travel
Editorial Boards:
1.
1) Disability and Rehabilitation: member of the editorial board (since 1997) 2) European Journal of Ageing: member of the editorial board (2004-2011)
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
1) Vifor Pharma : consultancy fees paid to my institution
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
Danone Institute: funding (1000 € to my institution) for a review paper in their bulletin
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
1)Lesieur: indirect benefit of research support(partial funding of measurement of plasma fatty acids not used in the present study) 2)Danone: research grant (paid to my institution)
Research Support, Government Entities:
1.
1)French National Research Agency (Agence Nationale de la Recherche, ANR): grant ANR-06-PNRA-005, 2007-2010 (paid to my institution) 2) Conseil Regional d’Aquitaine : funding of plasma fatty acids measurements used in the present study grant 20030305001A3B (paid to my institution)
Research Support, Academic Entities:
1.
Institut Carnot LISA (Lipids for Industry, Safety and Health)annual grant (paid to my institution)
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Study funding: Funding information is provided at the end of the article.
Correspondence & reprint requests to Dr. Samieri: [email protected]

Author Contributions

C. Samieri performed statistical analyses and wrote the manuscript. P. Maillard performed SPM analyses and helped to write the manuscript. F. Crivello contributed to data collection and provided significant advice. C. Proust-Lima contributed to statistical analyses and provided significant advice. E. Peuchant contributed to determining plasma fatty acid proportions. C. Helmer contributed to experiment design, data collection, and provided significant advice. H. Amieva contributed to data collection and provided significant advice. M. Allard contributed to experiment design, data collection, obtained funding, and provided significant advice. J.F. Dartigues contributed to experiment design, data collection, obtained funding, and provided significant advice. S.C. Cunnane helped to write and revise the manuscript and provided significant advice. B. Mazoyer contributed to experiment design, data collection, obtained funding, and provided significant advice. P. Barberger-Gateau contributed to experiment design, data collection, obtained funding, helped to write the manuscript, and provided significant advice. All the authors read the draft critically. C. Samieri had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Metrics & Citations

Metrics

Citations

Download Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.

Cited By
  1. Perspective Chapter: Pathophysiology of Spinal Cord Injury and Effect of Neutraceuticals in Providing Potential Health Benefits, Spinal Cord Injury - Current Trends in Acute Management, Function Preservation and Rehabilitation Protocols, (2023).https://doi.org/10.5772/intechopen.106275
    Crossref
  2. Omega-3 Fatty Acids, Cognition, and Brain Volume in Older Adults, Brain Sciences, 13, 9, (1278), (2023).https://doi.org/10.3390/brainsci13091278
    Crossref
  3. Impact of multidomain preventive strategies on functional brain connectivity in older adults with cognitive complaint: Subset from the Montpellier center of the ancillary MAPT-MRI study, Frontiers in Aging Neuroscience, 14, (2023).https://doi.org/10.3389/fnagi.2022.971220
    Crossref
  4. A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease, Nutrition and Healthy Aging, 8, 1, (143-156), (2023).https://doi.org/10.3233/NHA-220190
    Crossref
  5. Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer’s Disease and Subcortical Cerebrovascular Disease, Journal of Alzheimer's Disease, 93, 2, (665-682), (2023).https://doi.org/10.3233/JAD-220795
    Crossref
  6. Dietary Lipid Intervention in the Prevention of Brain Aging, Engineering, (2023).https://doi.org/10.1016/j.eng.2023.04.012
    Crossref
  7. Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depression and Mood Disorders, Neurobiological and Psychological Aspects of Brain Recovery, (253-287), (2023).https://doi.org/10.1007/978-3-031-24930-3_12
    Crossref
  8. Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson’s Disease, International Journal of Molecular Sciences, 23, 3, (1089), (2022).https://doi.org/10.3390/ijms23031089
    Crossref
  9. Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system, Frontiers in Psychiatry, 13, (2022).https://doi.org/10.3389/fpsyt.2022.933704
    Crossref
  10. Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife, Neurology, 99, 23, (e2572-e2582), (2022)./doi/10.1212/WNL.0000000000201296
    Abstract
  11. See more
Loading...

View Options

Get Access

Login options

Check if you have access through your login credentials or your institution to get full access on this article.

Personal login Institutional Login
Purchase Options

Purchase this article to get full access to it.

Purchase Access, $39 for 24hr of access

View options

Full Text

View Full Text

Full Text HTML

View Full Text HTML

Media

Figures

Other

Tables

Share

Share

Share article link

Share