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October 3, 2012

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

Debby Tsuang, MD, MSc, James B. Leverenz, MD, Oscar L. Lopez, MD, Ronald L. Hamilton, MD, David A. Bennett, MD, Julie A. Schneider, MD, MS, Aron S. Buchman, MD, … Show All … , Eric B. Larson, MD, MPH, Paul K. Crane, MD, MPH, Jeffrey A. Kaye, MD, Patricia Kramer, PhD, Randy Woltjer, MD, PhD, Walter Kukull, PhD, Peter T. Nelson, MD, PhD, Gregory A. Jicha, MD, PhD, Janna H. Neltner, MD, Doug Galasko, MD, Eliezer Masliah, MD, John Q. Trojanowski, MD, PhD, Gerard D. Schellenberg, PhD, Dora Yearout, BS, Haley Huston, BS, Allison Fritts-Penniman, BS, Ignacio F. Mata, PhD, Jia Y. Wan, MS, Karen L. Edwards, PhD, Thomas J. Montine, MD, PhD, and Cyrus P. Zabetian, MD, MSAuthors Info & Affiliations
November 6, 2012 issue
79 (19) 1944-1950
https://doi.org/10.1212/WNL.0b013e3182735e9a
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Abstract

Objectives:

Mutations in the GBA gene occur in 7% of patients with Parkinson disease (PD) and are a well-established susceptibility factor for PD, which is characterized by Lewy body disease (LBD) neuropathologic changes (LBDNCs). We sought to determine whether GBA influences risk of dementia with LBDNCs, Alzheimer disease (AD) neuropathologic changes (ADNCs), or both.

Methods:

We screened the entire GBA coding region for mutations in controls and in subjects with dementia and LBDNCs and no or low levels of ADNCs (pure dementia with Lewy bodies [pDLB]), LBDNCs and high-level ADNCs (LBD-AD), and high-level ADNCs but without LBDNCs (AD).

Results:

Among white subjects, pathogenic GBA mutations were identified in 6 of 79 pDLB cases (7.6%), 8 of 222 LBD-AD cases (3.6%), 2 of 243 AD cases (0.8%), and 3 of 381 controls (0.8%). Subjects with pDLB and LBD-AD were more likely to carry mutations than controls (pDLB: odds ratio [OR] = 7.6; 95% confidence interval [CI] = 1.8–31.9; p = 0.006; LBD-AD: OR = 4.6; CI = 1.2–17.6; p = 0.025), but there was no significant difference in frequencies between the AD and control groups (OR = 1.1; CI = 0.2–6.6; p = 0.92). There was a highly significant trend test across groups (χ2(1) = 19.3; p = 1.1 × 10−5), with the likelihood of carrying a GBA mutation increasing in the following direction: control/AD < LBD-AD < pDLB.

Conclusions:

GBA is a susceptibility gene across the LBD spectrum, but not in AD, and appears to convey a higher risk for PD and pDLB than for LBD-AD. PD and pDLB might be more similar to one another in genetic determinants and pathophysiology than either disease is to LBD-AD.

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Supplementary Material

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Information & Authors

Information

Published In

Neurology®
Volume 79 • Number 19 • November 6, 2012
Pages: 1944-1950
PubMed: 23035075

Copyright

Copyright © 2012 by AAN Enterprises, Inc.

Publication History

Received: April 30, 2012
Accepted: June 18, 2012
Published online: October 3, 2012
Published in issue: November 6, 2012

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Disclosure

D. Tsuang is funded by grants from Department of Veterans Affairs, NARSAD, and NIH. J. Leverenz has served as a consultant for Bayer and Teva Pharmaceuticals and is funded by grants from the American Parkinson Disease Association, Michael J. Fox Foundation, NIH, and Northwest Collaborative Care. O. Lopez is funded by the NIH. R. Hamilton performs diagnostic neuropathology (40% effort) and bills for these procedures. He is partly supported by grants from the NIH. D. Bennett serves on the editorial board of Neurology®; serves on the scientific advisory board for Vigorous Minds; serves/has served as a consultant to Danone Research B.V., Willmar Schwabe GmbH, Eli Lilly, and Gerson Lehrman Group; and receives research support from Danone Research B.V., the NIH, the Illinois Department of Public Health, and the Robert C. Borwell Endowment Fund. J. Schneider served on a scientific advisory board for GE Healthcare; serves as a consultant for Avid Radiopharmaceuticals, Inc.; and receives research support from Avid Radiopharmaceuticals, Inc. and the NIH. A. Buchman is funded by the NIH. E. Larson receives research support from the NIH. P. Crane is funded by grants from the Alzheimer's Association and NIH. J. Kaye receives research support from the Department of Veterans Affairs and the NIH. Individuals who work in the research centers he directs receive research support from Johnson & Johnson, Roche, and Bristol Myers Squibb. Dr. Kaye is compensated for serving on a data monitoring committee for Eli Lilly; he serves as a paid advisor for Janssen Pharmaceutical. Dr. Kaye receives reimbursement through Medicare or commercial insurance plans for providing clinical assessment and care for patients; is salaried to see patients at the Portland VA Medical Center; and serves as an unpaid Vice-Chair for the International Professional Interest Area Work Group of the International Society to Advance Alzheimer's Research and Treatments (ISTAART) and as an unpaid Commissioner for the Center for Aging Services and Technologies. P. Kramer reports no disclosures. R. Woltjer is funded by the NIH. W. Kukull is funded by grants from the Alzheimer's Association and NIH. P. Nelson is funded by grants from the NIH. G. Jicha serves as a consultant for Pfizer and Eli Lilly, and receives research support from Pfizer, Elan Corporation, Janssen, Medivation, Inc., Danone, and the NIH/NIA. J. Neltner reports no disclosures. D. Galasko serves on safety monitoring committees for clinical trials for Janssen Pharmaceuticals, Elan Pharmaceuticals, and Balance Pharmaceuticals, and has served as a paid advisor to Elan Pharmaceuticals, Phloronol, Inc., and United BioSource. He has received research funding from the National Institute on Aging. E. Masliah is funded by grants from the NIH. J. Trojanowski has received funding for travel and honoraria from Takeda Pharmaceutical Company, Ltd.; has received speaker honoraria from Pfizer; may accrue revenue on patents regarding modified avidin-biotin technique, method of stabilizing microtubules to treat Alzheimer disease, method of detecting abnormally phosphorylated tau, method of screening for Alzheimer disease or disease associated with the accumulation of paired helical filaments, compositions and methods for producing and using homogeneous neuronal cell transplants, rat comprising straight filaments in its brain, compositions and methods for producing and using homogeneous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries, diagnostic methods for Alzheimer disease by detection of multiple MRNAs, methods and compositions for determining lipid peroxidation levels in oxidant stress syndromes and diseases, compositions and methods for producing and using homogeneous neuronal cell transplants, method of identifying, diagnosing and treating α-synuclein positive neurodegenerative disorders, mutation-specific functional impairments in distinct tau isoforms of hereditary frontotemporal dementia and parkinsonism linked to chromosome-17: genotype predicts phenotype, microtubule stabilizing therapies for neurodegenerative disorders, and treatment of Alzheimer and related diseases with an antibody; and receives research support from the NIH (NIA, NINDS) and from the Marian S. Ware Alzheimer Program. G. Schellenberg serves on a scientific advisory board and receives honoraria from the American Health Assistance Foundation; has served as a consultant for and received funding for travel from Integra-Gen; holds/has filed patents regarding chromosome 14 and familial Alzheimer disease genetic markers and assays, chromosome 1 gene and gene products related to Alzheimer disease, and genetic basis of Alzheimer disease and diagnosis and treatment thereof; and receives/has received research support from the NIH (NIA, NIMH), the Autism Genome Project, Autism Speaks, CurePSP, the Rainwater Foundation, and Peebler PSP Research Foundation. He is an uncompensated member (other than travel funds to meetings of these boards) of the Alzheimer's Association Medical and Scientific Advisory Council, CSP #546 Executive Committee, Veterans Affairs Dementia Prevention Study of Vitamin E and Memantine, the Board of the Peebler PSP Research Foundation, and the Medical Advisory Board, Society of Progressive Supranuclear Palsy. D. Yearout and H. Huston receive salary support from the Department of Veterans Affairs and NIH. A. Fritts-Penniman received salary support from the Department of Veterans Affairs and NIH. I. Mata is funded by grants from the Department of Veterans Affairs, NIH, and Parkinson's Disease Foundation. J. Wan receives salary support from the Department of Veterans Affairs and NIH. K. Edwards and T. Montine are funded by grants from the NIH. C. Zabetian is funded by grants from the American Parkinson Disease Association, Department of Veterans Affairs, NIH, Northwest Collaborative Care, and Parkinson's Disease Foundation. Go to Neurology.org for full disclosures.

Authors

Affiliations & Disclosures

Debby Tsuang, MD, MSc*
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
1.NIH/NIA 1R01AG041797-01 Epidemiology of Familial Late-onset Alzheimer’s Disease, Site PI, 4/15/12-3/31/17. 2.NIH/NIMH RO1 MH065558 Consortium on the Genetics of Endophenotypes and Schizophrenia, PI, 4/1/10–3/31/14. 3. VA Merit ReviewIdentification of copy number variations in schizophrenia, PI, 10/1/09–9/30/13. 4. NIH/NIA P50 AG05136-22, Clinical Core, University of Washington Alzheimer’s Disease Research Center, Co-Director, 5/1/10-4/30/15 5.NIH/NIA U01 AG032984 Clinical Case-Control Genome Wide Association Studies, Alzheimer’s Disease Genetics Consortium, Co-PI, 3/1/09–2/29/12.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
National Alliance of Research on Schizophrenia and Affective Disorders, 9/15/09-9/14/12
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
James B. Leverenz, MD*
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Teva, speaker honorarium
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Commercial - Bayer, Teva
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
1. 7/15/09-7/14/14, NINDS, P50 NS062684-01, Pacific Northwest Udall Center, Role: Clinical Core Director 2. 5/1/10-4/30/15, NIH P50 AG05136, University of Washington Alzheimer’s Disease Research Center, Roles: Director Education and Information Transfer Core, Investigator Clinical Core 3. 9/30/10-8/31/13, NIH/NINDS RC4NS073008, IBIC: Integrated Brain Imaging Center for the University of Washington, Project 1 Leader 4. 10/97-present, VA, Mental Illness Research, Education and Clinical Center (MIRECC), Role: Investigator 5. 6/01-present, VA Parkinson’s Disease Research, Education and Clinical Center (PADRECC), Veterans Affairs, Role: Investigator/Clinician
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
1. 5/1/10-4/30/15, Michael J. Fox Foundation, Parkinson Progression Marker Initiative, Role: Site PI 2. 1/1/07-6/30/13, Washington Chapter American Parkinson’s Disease Association/Northwest Collaborative Care, Washington State Parkinson Disease Registry, Role: Co-Director 3. Continuing funding, American Parkinson’s Disease Association, Information & Referral Center, Role: Medical Director.
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Oscar L. Lopez, MD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Johnson & Johnson; Lundbeck
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIA: P50 AG05133-27; AG20098-09.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Ronald L. Hamilton, MD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
David A. Bennett, MD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
Vigorous Minds, Scientific Advisory Board
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
Neurology, Editorial Board; Current Alzheimer Research, Editorial Board; Neuroepidemiology, Editorial Board; Frontiers Neurology, Editorial Board
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Danone, Inc.; Wilmar Schwabe GmbH & Co.; Eli Lilly, Inc.; the Gerson Lehrman Group
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Danone Inc., PI
Research Support, Government Entities:
1.
NIH R01AG017917, PI; NIH R01AG015819, PI; NIH R01AG036042, PI; NIH RC2AG036547, PI; NIH U01AG032984, Co-PI, Leader of Epidemiologic Cohort Studies; NIH R01AG024480, Co-I; NIH R01AG024871, Co-I; NIH P01AG009466, Co-I; NIH U24AG026395, Co- I; NIH R01AG030142, Co-I; NIH P01AG01449, Co-I; NIH R01HL096944, Co-I; NIH R01AG033678, Co-I; NIH R01AG034374, Co-I; NIH R01AG032755, Co-I; NIH P30AG010161, PI-Administrative core leader, Religious Orders Study core leader; Illinois Department Public Health
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Julie A. Schneider, MD, MS
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
1. served on scientific advisory board for GE Healthcare; 2. served on scientific advisory board for Eli Lilly and Company;
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
2005-current Journal Histochemistry and Cytochemistry (Monitoring editor) 2008-current International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) (Editorial Board) 2010 Journal of Alzheimer’s Disease (Associate Editor)
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Neuropathology consultant, AVID radiopharmaceuticals 2009-12
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
AVID radiopharmaceutical phase III clinical trial Neuropathologist 2010-2011
Research Support, Government Entities:
1.
P30 AG10161 (Bennett)9/30/91-6/30/11 Rush Alzheimer’s Disease Core Center; Major goals to provide core infrastructure support for research regarding aging/AD. Role: Core Leader: Neuropathology Core R01 AG031553 (Morris)3/15/08 – 2/28/13 Epidemiologic Study of Brain Vitamin E, Diet, and Age- Related Neurologic Diseases; major goal is analyze Vitamin E in brain, CSF, serum, and diet and compare to neuropathology. Role: Co-Investigator R01 AG17917 (Bennett)9/30/01-6/30/13 Epidemiologic Study of Neural Reserve and Neurobiology of Aging; Major goals are to identify structural bases of reserve and examine mechanisms risk factors lead to age- related functional impairment.Role:Co-Investigator R01 AG024480 (Buchman)7/1/05 – 6/30/10 Risk Factors and the Neurobiologic Substrate of Frailty; Major goals of this project are to identify the neurobiologic substrate of physical frailty and identify risk factors for frailty. Role: Co-Investigator R01 AG15819 (Bennett) 7/1/98 – 6/30/13 Risk Factors, Pathology and Clinical Expressions of AD The major goals of this project are to examine the pathologic mechanisms through which risk factors lead to clinical AD. Role: Co-investigator P01 AG14449 (Mufson)9/1/97 – 3/31/13 Neurobiology of Mild cognitive impairment in the Elderly;The major goals are to identify neurobiologic substrates of mild cognitive impairment. Role: Co-investigator (Neuropathologist) P01 AG09466 (deToledo-Morrell)4/1/1991-8/31/10 Anatomic, Physiologic, Cognitive Pathology of AD; Major goals to identify neurobiologic, radiologic, physiologic, cognitive markers of AD Role: Co-Investigator; Neuropathologist, Administrative Core R01 AG24871 (Wilson)7/1/06 – 4/30/11 Neurobiologic Study of Psychological Distress & Dementia; Major goal to identify the mechanisms underlying the association of chronic psychological distress with dementia. Role: Co-investigator (Neuropathologist) R21 AG30765 (Bennett)9/1/07 – 6/30/10 Degraded Rationality: Subclinical Neuropathology and Neuroeconomic Behavior in Older Persons Role: Co-Investigator R21 AG030346 (Kelly)9/30/08 – 8/31/10 Relationship Between AD Clinicopathological Changes and CNS Sex Steroid Hormones; Major goal is to determine the relationship between brain tissue hormone levels and cognitive impairment, and AD pathology. Role: Neuropathologist R01AG033678-01(Boyle)9/15/2009 - 6/30/14 Epidemiologic study of Impaired decision making in preclinical Alzheimer’s disease. The overall goal of the proposed epidemiologic study is to examine the causes and consequences of impaired decision-making in old age. Role: Neuropathologist R01AG034374 (Boyle)8/15/2009 -7/31/14 Characterizing the behavior profile of healthy cognitive aging. Goal is to use innovative statistical approaches to characterize the profile of healthy cognitive aging defined as age-related cognitive change not accounted for by the presence of common neuropathologies (i.e., Alzheimer’s disease, cerebral infarcts, and the Lewy body diseases) or terminal decline. Role: Neuropathologist.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Aron S. Buchman, MD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH R01AG17917, co-I, 2001-13; NIH R01AG24480, PI, 2005-12
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Eric B. Larson, MD, MPH
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
American Journal of Medicine (1997-present); Health Services Research (1994-present); ACP Journal Club (1990-present)
Patents:
1.
NONE
Publishing Royalties:
1.
Up To Date (ongoing), Chapter author; Geriatric Medicine, 4th edition, Springer, 2003
Employment, Commercial Entity:
1.
Group Health Cooperative, Vice President for Research; Executive Director and Senior Investigator, Group Health Research Institute
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIA AG 06781, PI, 1986-2014; NHGRI HG 004610, PI and Co-PI, 2007-2015
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Paul K. Crane, MD, MPH
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
Journal of the American Geriatrics Society, 2011 on, editorial board member
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH: NIA, NIAMS, NHGRI. Various roles (PI, multiple PI, co-I).
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Jeffrey A. Kaye, MD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
Eli Lily data safety monitoring board for Alzheimer’s drug; Janssen Research Advisory Committee
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
Frontiers of Aging Neuroscience, Associate Editor Alzheimer and Dementia, Editorial Advisory Board
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
Funded for research by the Department of Veteran’s Affairs by a Merit Review grant, and National Institutes of Health (NIH) grants # P30AG024978, R01AG024059, P30 AG008017. All as PI; all current.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Patricia Kramer, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
National Alzheimer’s Coordinating Committee Scientifc REview Board
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Randy Woltjer, MD, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH/NIA P30 AG08017 (P.I. Jeffrey Kaye), director of neuropathology core of Alzheimer’s Disease Center, 2005-2009. NIH/NIA, 5R01AG026916 (P.I. Patricia Kramer), consultant, 2008-2009
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Medical Research Foundation of Oregon, Principal Investigator, 2008-2009 OHSU Dean’s Fund for Research Collaboration, Coinvestigator, 2008-2009 Oregon Tax Checkoff Small Grant Award, Principal Investigator, 2007-2008
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Walter Kukull, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
Scientific advisory review panel for Michael J Fox foundatation; review of several grants (honoraria per occasion) NIH study section until June 2011
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Univ of Florida, Gainesville. travel and lodging to give a talk on Alzheimer’s disease. Feb, 2012.
Editorial Boards:
1.
Editorial board member 2002-present: Alzheimer’s Disease and Associated Disorders (no pay)
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
1) External Advisory committee: UC Irvine ADRC 2)External Advisory committee:UCLA ADRC 3)External Advisory committee: Mt Sinai ADRC 4) External Advisory committee:University of Kansas ADRC 5) Scientific Advisory Committee: Biocard Study, JHU
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
National Institute on Aging, U01 AG016976,1999-present, PI as obtained through the University of Washington
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Alzheimer’s Association, Lumbar puncture survey study LPSS 11-219245 Principal Investigator
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Peter T. Nelson, MD, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Gregory A. Jicha, MD, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Alzheimer Association
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
Pfizer Eli Lilly
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Pfizer Elan Jannsen Medivation Danone
Research Support, Government Entities:
1.
NIH/NIA 1 P30 AG028383-03 NIH/NIA 2R01AG019241-06A2 NIH/NIA ADC-0272U01AG010483
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Janna H. Neltner, MD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
1. National Institutes of Health,P30 AG028383, PI (pilot grant), 1 year.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Doug Galasko, MD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
DSMB for Jansen-Elan clinical trial for Alzheimer’s Disease DSMB for Elan Clinical trial for Alzheimer’s Disease
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
Alzheimer’s Research and Therapy. Co-Editor, 2009-2012
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
United BioSource Corporation Elan Pharmaceuticals, Inc Phloronol, Inc.
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Eli Lilly, Inc.; AVID Pharmaceuticals, Inc
Research Support, Government Entities:
1.
National Institute on Aging, AGO 5131, PI, 2009 - present
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Michael J Fox Foundation
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Eliezer Masliah, MD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH NIA AG5131, AG18440
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
John Q. Trojanowski, MD, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Dr. Trojanowski may accrue revenue in the future on patents submitted by the University of Pennsylvania wherein he is co-Inventor and he received revenue from the sale of Avid to Eli Lily as co-inventor on imaging related patents submitted by the University of Pennsylvania while he receives research support from the NIH, Bristol Myer Squib, AstraZenica and several non- profits.
Editorial Boards:
1.
Alzheimer’s & Dementia, Associate Editor
Patents:
1.
holds 14 patents that may accrue revenue: US Patent 5,281,521, issued 25 Jan 1994: Modified Avidin-Biotin Technique; US Patent 5,580,898, issued 3 Dec 1996: Method of Stabilizing Microtubules to Treat Alzheimer’s Disease; US Patent 5,601,985, issued 11 Feb 1997: Method of Detecting Abnormally Phosphorylated Tau; US Patent 5,733,734, issued 31 Mar 1998: Method of Screening for Alzheimer’s Disease or Disease Associated with the Accumulation of Paired Helical Filaments; US Patent 5,792,900, issued 11 Aug 1998: Compositions and Methods for Producing and Using Homogeneous Neuronal Cell Transplants; US Patent 5,849,988, issued 15 Dec 1998: Rat Comprising Straight Filaments in Its Brain; US Patent 6,214,334, issued 10 Apr 2001: Compositions And Methods for Producing and Using Homogeneous Neuronal Cell Transplants to Treat Neurodegenerative Disorders and Brain and Spinal Cord Injuries; US Patent 6,358,681, issued 19 Mar 2002: Diagnostic Methods for Alzheimer’s Disease by Detection of Multiple MRNAs; US Patent 6,727,075, issued 27 Mar 2004: Methods and Compositions for Determining Lipid Peroxidation Levels in Oxidant Stress Syndromes and Diseases; US Patent 7,011,827, issued 14 Mar 2006: Compositions and Methods for Producing and Using Homogenous Neuronal Cell Transplants; Penn 0652, K1828, filed 5 Aug 1998: Method of Identifying, Diagnosing and Treating Alpha-synuclein Positive Neurodegenerative Disorders; Penn L1986, Filed 13 Nov 1998: Mutation-specific Functional Impairments in Distinct Tau Isoforms of Hereditary Frontotemporal Dementia and Parkinsonism Linked to Chromosome- 17: Genotype Predicts Phenotype; Penn R3868 (UPN-4439), filed 28 Feb 2005: Microtubule Stabilizing Therapies for Neurodegenerative Disorders; and Penn S-4018, DB&R 46406- 217282, filed 22 Nov 2005: Treatment of Alzheimer’s and Related Diseases with an Antibody
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
receives research support from the NIH (NIA P01 AG 09215-20 [PI], NIA P30 AG 10124-18 [PI], NIA PO1 AG 17586-10 [Project 4 Leader], NIA 1PO1 AG-19724-07 [Core C Leader], NIA 1 U01 AG 024904-05 [Co-PI Biomarker Core Laboratory], NINDS P50 NS053488-02 [PI], NIA UO1 AG029213-01 [Co-I]; RC2NS069368 [PI], RC1AG035427 [PI], and NIA P30AG036468 [PI])
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
The Marian S. Ware Alzheimer Program, Benaroya
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Gerard D. Schellenberg, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
Alzheimer’s Association Veterans Affairs Cooperative Study Unit Executive Committee, Autism Genome Project, National Alliance for Autism Research Medical Advisory Board, Society of Progressive Supranuclear Palsy Scientific Advisory Board, Alzheimer Research Consortium Executive Board – Autism Genome Project Peebler PSP Research Foundation
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Alzheimer’s Disease Center Directors Meeting - travel/lodging Simon Lecture, travel/lodging Boston University School of Medcine and Brighams and Womens Hospital, Boston, travel/lodging M CurePSP International Research Symposium, travel/lodging Alzheimer’s Disease”, Brain Degeneration and Mental Health Challenges in Sub-Sahara Africa. travel/lodging Columbia University, travel/lodging Alzheimer’s Disease Centers Director’s meeting, travel/lodging “Alzheimer’s Disease Genetics” VIII Conferencia Bienal Barcelona/Pittsburgh, travel/lodging
Editorial Boards:
1.
1989- present:Advisory Board for the Dementia Section, Journal of Neural Transmission Editorial Board, Alzheimer’s Research Editorial Board, American Journal of Alzheimer’s Disease and other Dementias. Editorial Board, Neurodegenerative Diseases Editorial Board, Current Alzheimer Research Editorial Board - Pathology and Laboratory Medicine International
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
Professor - University of Pennsylvania
Consultancies:
1.
Finnigan Law firm
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Integregen for autism research
Research Support, Government Entities:
1.
NIA/NIH
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
CurePSP Autism Speaks
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
Finnigan Law firm
View all articles by this author
Dora Yearout, BS
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
I receive salary support from Department of Veterans Affairs and National Institutes of Health.
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Haley Huston, BS
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
I receive(d) salary support from Department of Veterans Affairs and National Institutes of Health.
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Allison Fritts-Penniman, BS
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
I received salary support from Department of Veterans Affairs and National Institutes of Health
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Ignacio F. Mata, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
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NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH/NINDS,R01 NS065070-02, co-PI, 2009-2013; Veterans Affairs, 1I01BX000531-02, co-PI, 2009-2013; NIH/NINDS,P50 NS062684-01A1, co-PI, 2009-2014
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
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1.
NONE
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1.
NONE
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NONE
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NONE
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Jia Y. Wan, MS
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
Department of Epidemiology, University of Washington; Center for Biomedical Statistics, University of Washington; Northwest Institute of Genetic Medicine, University of Washington
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Karen L. Edwards, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH R01 CA149051-01A1: PI: 03/01/2011 – 02/28/2014 CDC U10/CCU025038-01: PI: 10/01/01 – 08/31/11 NIH P50 NS062684-01A1: CoInvest: 08/01/09 - 07/31/14 NIH R01 HL098227: CoInvest: 08/01/10 – 05/31/14 NIH P50 HG 3374-01:CoInvest:9/1/04 - 7/31/15 NIH PO-1-ES-04068: CoInvest: 09/01/07- 06/30/12 NIH R01 HL089807: CoInvest:8/1/07 - 7/31/12 NIH R01 HG005840-01: CoInvest: 08/16/2010 – 05/31/2012
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Thomas J. Montine, MD, PhD
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
American Journal of Pathology Brain Pathology Journal of Alzheimer’s Disease
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH
Research Support, Academic Entities:
1.
Nancy and Buster Alvord Endowment
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Cyrus P. Zabetian, MD, MS
From the Veterans Affairs Puget Sound Health Care System (D.T., J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Seattle, WA; Departments of Psychiatry and Behavioral Sciences (D.T., J.B.L.), Neurology (J.B.L., D.Y., H.H., A.F.-P., I.F.M., C.P.Z.), Medicine (E.B.L., P.K.C.), Epidemiology (W.K., J.Y.W., K.L.E.), and Pathology (T.J.M.), University of Washington, Seattle; Departments of Neurology (O.L.L.) and Pathology (R.L.H.), University of Pittsburgh, Pittsburgh, PA; Departments of Neurological Sciences (D.A.B., A.S.B.) and Pathology (J.A.S.), Rush University, Chicago, IL; Group Health Cooperative (E.B.L.), Seattle, WA; Departments of Neurology (J.A.K., P.K.) and Pathology (R.W.), Oregon Health & Science University, Portland; Departments of Pathology (P.T.N., G.A.J., J.H.N.) and Neurology (G.A.J.), University of Kentucky, Lexington; Departments of Neurology (D.G.) and Pathology (E.M.), University of California, San Diego; and Department of Pathology and Laboratory Medicine (J.Q.T., G.D.S.) and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers’ Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
1) NIH/NINDS, R01 NS065070, PI, 2009-2013 2) NIH/NINDS, P50 NS062684, PI (Project 3), 2009-2014 3) Department of Veterans Affairs, 1I01BX000531, PI, 2009-2013 4) NIH/NINDS, R01 NS036960, co-investigator, 1998-2013 5) NIH/NINDS, R01 NS057567, co-investigator, 2008-2013 6) NIH/NIA, R01 AG033398, co-investigator, 2008-2013 7) Department of Veterans Affairs, REAP Grant, co-investigator, 2005-2010
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
1) Parkinson’s Disease Foundation, International Research Program Grant, PI, 2010-2012 2) American Parkinson Disease Association, Research Grant, co-PI, 2007-2014 3) Northwest Collaborative Care, Research Grant, co-PI, 2007-2012
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author

Notes

*
These two authors contributed equally to this work.
Study funding: Supported by grants from the Department of Veterans Affairs (1I01BX000531) and the National Institutes of Health (P30 AG008017, P30 AG028383, P30 AG010124, P30 AG010161, P50 AG005131, P50 NS062684, P50 AG005136, P50 AG005133, R01 AG007584, R01 AG010845, R01 AG015819, R01 AG017917, R01 NS048595, R01 NS065070, U01 AG006781, and U01 AG016976).
Correspondence & reprint requests to Dr. Zabetian: [email protected] Or Dr. Tsuang: [email protected]

Author Contributions

Dr. Tsuang: study concept and design, acquisition of data, interpretation of data, drafting of the manuscript, and obtaining funding. Dr. Leverenz: study concept and design, acquisition of data, interpretation of data, and drafting of the manuscript. Dr. Lopez: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and obtaining funding. Dr. Hamilton: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Bennett: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and obtaining funding. Dr. Schneider: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Buchman: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Larson: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and obtaining funding. Dr. Crane: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Kaye: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and obtaining funding. Dr. Kramer: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Woltjer: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Kukull: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and obtaining funding. Dr. Nelson: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Jicha: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Neltner: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Galasko: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and obtaining funding. Dr. Masliah: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Dr. Trojanowski: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and obtaining funding. Dr. Schellenberg: critical revision of the manuscript for important intellectual content, interpretation of data, and obtaining funding. Ms. Yearout: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and technical support. Ms. Huston: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and technical support. Ms. Fritts-Penniman: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and technical support. Dr. Mata: critical revision of the manuscript for important intellectual content, acquisition of data, and interpretation of data. Ms. Wan: statistical analysis, interpretation of data, and critical revision of the manuscript for important intellectual content. Dr. Edwards: statistical analysis, interpretation of data, and critical revision of the manuscript for important intellectual content. Dr. Montine: critical revision of the manuscript for important intellectual content, acquisition of data, interpretation of data, and obtaining funding. Dr. Zabetian: study concept and design, acquisition of data, interpretation of data, drafting of the manuscript, and obtaining funding.

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