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February 27, 2013

Brain β-amyloid load approaches a plateau

Clifford R. Jack, Jr, MD, Heather J. Wiste, Timothy G. Lesnick, Stephen D. Weigand, David S. Knopman, MD, Prashanthi Vemuri, PhD, Vernon S. Pankratz, PhD, … Show All … , Matthew L. Senjem, Jeffrey L. Gunter, PhD, Michelle M. Mielke, PhD, Val J. Lowe, MD, Bradley F. Boeve, MD, and Ronald C. Petersen, MD, PhDAuthors Info & Affiliations
March 5, 2013 issue
80 (10) 890-896
https://doi.org/10.1212/WNL.0b013e3182840bbe
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Abstract

Objective:

To model the temporal trajectory of β-amyloid accumulation using serial amyloid PET imaging.

Methods:

Participants, aged 70–92 years, were enrolled in either the Mayo Clinic Study of Aging (n = 246) or the Mayo Alzheimer's Disease Research Center (n = 14). All underwent 2 or more serial amyloid PET examinations. There were 205 participants classified as cognitively normal and 55 as cognitively impaired (47 mild cognitive impairment and 8 Alzheimer dementia). We measured baseline amyloid PET-relative standardized uptake values (SUVR) and, for each participant, estimated a slope representing their annual amyloid accumulation rate. We then fit regression models to predict the rate of amyloid accumulation given baseline amyloid SUVR, and evaluated age, sex, clinical group, and APOE as covariates. Finally, we integrated the amyloid accumulation rate vs baseline amyloid PET SUVR association to an amyloid PET SUVR vs time association.

Results:

Rates of amyloid accumulation were low at low baseline SUVR. Rates increased to a maximum at baseline SUVR around 2.0, above which rates declined—reaching zero at baseline SUVR above 2.7. The rate of amyloid accumulation as a function of baseline SUVR had an inverted U shape. Integration produced a sigmoid curve relating amyloid PET SUVR to time. The average estimated time required to travel from an SUVR of 1.5–2.5 is approximately 15 years.

Conclusion:

This roughly 15-year interval where the slope of the amyloid SUVR vs time curve is greatest and roughly linear represents a large therapeutic window for secondary preventive interventions.

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Supplementary Material

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Information & Authors

Information

Published In

Neurology®
Volume 80 • Number 10 • March 5, 2013
Pages: 890-896
PubMed: 23446680

Copyright

© 2013 American Academy of Neurology.

Publication History

Received: June 1, 2012
Accepted: September 25, 2012
Published online: February 27, 2013
Published in print: March 5, 2013

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Disclosure

C.R. Jack serves as a consultant for Janssen, Bristol-Meyer-Squibb, General Electric, and Johnson and Johnson, and is involved in clinical trials sponsored by Allon and Baxter, Inc. He receives research funding from the NIH (R01-AG011378, RO1-AG037551, U01-HL096917, U01-AG032438, U01-AG024904) and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation. H. Wiste, T. Lesnick, and S. Weigand report no disclosures. D. Knopman serves as Deputy Editor for Neurology®, serves on a Data Safety Monitoring Board for Lilly Pharmaceuticals, is an investigator in clinical trials sponsored by Janssen Pharmaceuticals, and receives research support from the NIH. P. Vemuri reports no disclosures. V.S. Pankratz is funded by the NIH (R01AG040042, U01AG06786, Mayo Clinic Alzheimer's Disease Research Center/Core C P50AG16574/Core C, and R01AG32990). M. Senjem, J. Gunter, and M. Mielke report no disclosures. V. Lowe serves on scientific advisory boards for Bayer Schering Pharma and GE Healthcare and receives research support from GE Healthcare, Siemens Molecular Imaging, the NIH (NIA, NCI), the MN Partnership for Biotechnology and Medical Genomics, and the Leukemia & Lymphoma Society. B. Boeve has served as a consultant to GE Healthcare; receives publishing royalties for The Behavioral Neurology of Dementia (Cambridge University Press, 2009); and receives research support from Cephalon, Inc., Allon Therapeutics, Inc., the NIH/NIA, the Alzheimer's Association, and the Mangurian Foundation. R. Petersen reports receiving consulting fees from Elan Pharmaceuticals and GE Healthcare, receiving royalties from Oxford University Press, and serving as chair of data monitoring committees for Pfizer and Janssen Alzheimer Immunotherapy; and receives research support from the NIH/NIA. Go to Neurology.org for full disclosures.

Study Funding

Funding sources include the NIH, National Institute on Aging R01 AG11378, P50 AG16574, and U01 AG06786. The General Electric Corporation also provided funding for some imaging studies used in this analysis. Also supported by US NIH Construction Grant (NIH C06 RR018898), The Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation, USA, and the Robert H. and Clarice Smith Alzheimer's Disease Research Program of the Mayo Foundation.

Authors

Affiliations & Disclosures

Clifford R. Jack, Jr, MD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
scientific advisory panels: (1) Elan, (2) Lilly, (3) GE, (4) Eisai, (5) Janssen, (6) Johnson and Johnson, (7) Bristol Meyer Squibb, (8) Siemens
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
Investigator in clinical trials sponsored by Baxter, Allon, and the National Institute on Aging
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Allon and Baxter, perform MRI related services for clinical trial
Research Support, Government Entities:
1.
RO1 AG11378 PI; U01 AG024904-01 co-I; RO1 AG37551 co-I; 1U01HL096917 co-I; U01 AG032438 co-I
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
Johnson and Johnson, 2010
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Heather J. Wiste
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Timothy G. Lesnick
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Stephen D. Weigand
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
David S. Knopman, MD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
Lilly Pharmaceuticals, Data Safety Monitoring Board, ended 8/22/12; TauRx consultant 2012; Consultant, McGill University Alzheimer Program 9/19/12
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
(1) Lecture, University of Toronto, March 2012
Editorial Boards:
1.
Neurology, Deputy Editor
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
(1) Janssen Alzheimer Immunotherapy program 3/29/11: honorarium paid to my institution; (2) Merck Alzheimer program 11/5/11 paid to my institution.
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
(1) Janssen for Alzheimer clinical trial, (2) Forest Laboratories for clinical trial in FTLD with memantine, (3) Baxter Laboratories for Alzheimer Clinical trial
Research Support, Government Entities:
1.
NIH: R01-AG11378 ongoing, P50-AG 16574 (Mayo Alzheimer's Disease Research Center) ongoing, U01 AG 06786 (Mayo Alzheimer Disease Patient Registry) ongoing. NIH R01 AG32306 FTD Neuro-imaging;Initiative. 1U01HL096917-01 ARIC Dementia Study.AG 037551 Chronic Kidney Disease and Cognitive functioning.
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Prashanthi Vemuri, PhD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Vernon S. Pankratz, PhD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
(1) NIA, P50 AG16574, Data Core Director, 2004-present(2) NIA, U01 AG06786, Co-Investigator, 2005-present(3) NIA, R01 AG32990, Co-Investigator, 2009-present
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Matthew L. Senjem
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Jeffrey L. Gunter, PhD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
Employment at Mayo Clinic
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Michelle M. Mielke, PhD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
Dr. Mielke was funded by the following NIH grants:U01 AG037526, role: PI, Date: 08/15/2010-06/30/2015;R21 NS06027-01, role: PI, Date: 07/15/07-06/30/09;R21 AG028754, role: PI, Date: 09/01/07-08/31/09'R01 AG21136, role: Investigator, Date: 9/01/02-8/31/08
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Dr. Mielke also received research support from the Georgeand Cynthia Mitchell Foundation. Role: co-PI, Date: 07/01/2007-06/30/2010 and Walter S. and Lucienne B. Driskill Foundation which started in May 2012.
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Val J. Lowe, MD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
(1) Bayer Pharmaceuticals
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
(1) GE Health Care(2) Siemens Molecular Imaging(3) AVID Radiopharmaceuticals
Research Support, Government Entities:
1.
(1) NIA R01 DC010367-01, CoI, 12/01/09-11/30/14(2) NIA P50 AG016574-12, Co-PI Project #1, 05/01/09-04/30/14(3) NIA R01 AG011378-16, CoI, 06/01/08-05/31/13(4) NCI R01 CA136526-02, CoI, 01/01/09-11/30/14(5) P30 CA015083-35, Program Director, 07/01/09-06/30/1(6) P50 CA102701-07, CoI, 09/01/08-08/31/13(7) R01 CA125614-04, CoI,09/26/06-07/31/11(8)R21 CA123909-02, CoI, 07/01/07-08/01/12
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
(1)MN Partnership for Biotechnology and Medical Genomics, PI, 01/01/09-12/31/12
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Bradley F. Boeve, MD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
Behavioral Neurology Of Dementia, Cambridge Univeristy Press, 2009
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Grant support as an investigator in clinical trials funded by (1) Cephalon, Inc., 2009-present, (2) Allon Therapeutics, Inc., 2010-present; and (3) GE Healthcare, 2012-present.
Research Support, Government Entities:
1.
(1) National Institute on Aging [P50 AG016574 (Co-Investigator, 2009-present), U01 AG006786 (Co-Investigator, 2009-present), RO1 AG032306 (Co-Investigator, 2010-present)(2) Center for Inherited Disease Research [U24 AG026395 (Co-Investigator, 2009-present)
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Mangurian Foundation, 2011-present
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author
Ronald C. Petersen, MD, PhD
From the Departments of Radiology (C.R.J., P.V., M.L.S., J.L.G.), Health Sciences Research (H.J.W., T.G.L., S.D.W., V.S.P.), Neurology (D.S.K., B.F.B., R.C.P.), Epidemiology (M.M.M.), and Nuclear Medicine (V.J.L.), Mayo Clinic, Rochester, MN.
Disclosure
Scientific Advisory Boards:
1.
(1) Pfizer, Inc., Chair, Data Monitoring Committee ; (2) Janssen Alzheimer Immunotherapy, Chair, Data Monitoring Committee
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
Mild Cognitive Impairment,Oxford University Press, 2003
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
(1) Elan Pharmaceuticals, (2) GE Healthcare
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
Novartis CME lecture
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
National Institute on Aging:U01-AG006786 (PI) (1986-present)P50-AG016574 (PI) (1990-present)R01-AG011378 (Co-I)U01-AG024904 (Co-I)
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
View all articles by this author

Notes

Correspondence to Dr. Jack: [email protected]
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

Author Contributions

Clifford R. Jack: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, contribution of vital reagents/tools/patients, acquisition of data, statistical analysis, study supervision, obtaining funding. Heather Wiste: drafting/revising the manuscript, analysis or interpretation of data, statistical analysis. Timothy G. Lesnick: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, statistical analysis. Stephen D. Weigand: drafting/revising the manuscript, analysis or interpretation of data, statistical analysis. David S. Knopman: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, acquisition of data. Prashanthi Vemuri: drafting/revising the manuscript, analysis or interpretation of data. Vernon Shane Pankratz: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, statistical analysis. Matthew L. Senjem: drafting/revising the manuscript, analysis or interpretation of data, contribution of vital reagents/tools/patients, acquisition of data, statistical analysis. Jeffrey L. Gunter: drafting/revising the manuscript, analysis or interpretation of data, statistical analysis. Michelle M. Mielke: drafting/revising the manuscript, analysis or interpretation of data. Val J. Lowe: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, contribution of vital reagents/tools/patients, acquisition of data, study supervision, obtaining funding. Bradley F. Boeve: analysis or interpretation of data, acquisition of data. Ronald C. Petersen: drafting/revising the manuscript, obtaining funding.

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