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November 1, 1981

Kluver‐Bucy Syndrome in Pick disease
Clinical and pathologic correlations

November 1981 issue
31 (11) 1415

Abstract

The clinical and neuropathologic findings of five cases of Pick disease were studied. All had severe anterior temporal atrophy and abnormal neurons with highly argyrophilic cytoplasm of Pick bodies. The amygdala was abnormal in every case and had severe involvement of all nuclear subdivisions. Behaviorally, the patients exhibited elements of Kluver-Bucy syndrome early in the disease. Language abnormalities were also prominent. Memory and spatial orientation were frequently spared until late. Computed tomography (CT) demonstrated marked lobar atrophy in one of two patients examined. The early appearance of Kluver-Bucy syndrome and the late occurrence of amnesia and spatial disorientation allow clinical identificaiton of this variant of Pick disease.

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Published In

Neurology®
Volume 31Number 11November 1981
Pages: 1415
PubMed: 7198189

Publication History

Published online: November 1, 1981
Published in print: November 1981

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Authors

Affiliations & Disclosures

J. L. Cummings, M.D.
Department of Neuropathology, (Drs. Cummings and Duchen), Institute of Neurology, National Hospital for Nervous Diseases, London, England, and the Neurobehavior Unit, Brentwood Veterans Administration Medical Center and Department of Neurology (Dr. Cummings), UCLA School of Medicine, Los Angeles, CA.
L. W. Duchen, M.D., Ph.D.
Department of Neuropathology, (Drs. Cummings and Duchen), Institute of Neurology, National Hospital for Nervous Diseases, London, England, and the Neurobehavior Unit, Brentwood Veterans Administration Medical Center and Department of Neurology (Dr. Cummings), UCLA School of Medicine, Los Angeles, CA.

Notes

Address correspondence and reprint requests to Dr. Cummings, Neurobehavior Unit, Ward 208C, VA Medical Center Brentwood, 11301 Wilshire Boulevard, Los Angeles, CA 90073.

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  3. The 100 Most Cited Kluver-Bucy Research Articles: A Bibliometric Analysis, Cureus, (2023).https://doi.org/10.7759/cureus.45382
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