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November 1, 1982

Moderate hyperglycemia augments ischemic brain damage
A neuropathologic study in the rat

November 1982 issue
32 (11) 1239


We compared the effects of glucose injection with those of saline or mannitol on ischemic brain damage and brain water content in a four-vessel occlusion (4-VO) rat model, which simultaneously causes severe forebrain ischemia and moderate hindbrain ischemia. Glucose given before onset of ischemia was followed by severe brain injury, with necrosis of the majority of neocortical neurons and glia, substantial neuronal damage throughout the remainder of forebrain, and severe brain edema. By comparison, saline injection before forebrain ischemia resulted in only scattered ischemic damage confined to neurons and no change in the brain water content. Mannitol injection before 4-VO or D-glucose injection during or after 4-VO produced no greater forebrain damage than did the saline injection. Morphologic damage in the cerebellum, however, was increased by D-glucose injection given either before or during 4-VO. The results demonstrate that hyperglycemia before severe brain ischemia or during moderate ischemia markedly augments morphologic brain damage.

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Published In

Volume 32Number 11November 1982
Pages: 1239
PubMed: 6890157

Publication History

Published online: November 1, 1982
Published in print: November 1982


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Affiliations & Disclosures

William A. Pulsinelli, M.D., Ph.D.
Department of Neurology, Cornell University Medical College, New York, NY.
Stephanie Waldman, B.S.
Department of Neurology, Cornell University Medical College, New York, NY.
Donald Rawlinson, M.D.
Department of Neurology, Cornell University Medical College, New York, NY.
Fred Plum, M.D.
Department of Neurology, Cornell University Medical College, New York, NY.

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