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Articles
May 1, 1987

Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles

May 1987 issue
37 (5) 768

Abstract

Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles both in isolated neurofibrillary tangle-bearing nerve cells and in partially purified preparations of tangle fibers. Antibody staining was preab-sorbed by preincubation of antibody with neuronal ganglioside preparations. These results suggest that Alzheimer's neurofibrillary tangles have a ganglioside associated with them.

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Published In

Neurology®
Volume 37Number 5May 1987
Pages: 768
PubMed: 3574674

Publication History

Published online: May 1, 1987
Published in print: May 1987

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Affiliations & Disclosures

Carolyn R. Emory, BS
Psychiatry Research Laboratories, Ramsey Clinic/St. Paul-Ramsey Medical Center, St. Paul, MN.
Thomas A. Ala, MD
Psychiatry Research Laboratories, Ramsey Clinic/St. Paul-Ramsey Medical Center, St. Paul, MN.
William H. Frey, II, PhD
Psychiatry Research Laboratories, Ramsey Clinic/St. Paul-Ramsey Medical Center, St. Paul, MN.

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Cited By
  1. Gangliosides smelt nanostructured amyloid Aβ(1–40) fibrils in a membrane lipid environment, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1864, 1, (183749), (2022).https://doi.org/10.1016/j.bbamem.2021.183749
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  2. The interaction of Aβ42 peptide in monomer, oligomer or fibril forms with sphingomyelin/cholesterol/ganglioside bilayers, International Journal of Biological Macromolecules, 168, (611-619), (2021).https://doi.org/10.1016/j.ijbiomac.2020.11.112
    Crossref
  3. Glycoconjugate Changes in Aging and Age-Related Diseases, Glycobiology of the Nervous System, (415-447), (2014).https://doi.org/10.1007/978-1-4939-1154-7_19
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  4. Lipid Metabolism in Neurodegenerative Diseases, Lipidomics, (269-296), (2012).https://doi.org/10.1002/9783527655946.ch14
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  5. Glycolipids: Structure and Function, Glycosciences, (163-189), (2008).https://doi.org/10.1002/9783527614738.ch9
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  6. Humoral and Cellular Immunologic Repertoire in Alzheimer's Disease, Annals of the New York Academy of Sciences, 663, 1, (349-356), (2006).https://doi.org/10.1111/j.1749-6632.1992.tb38678.x
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  7. Monoclonal Antibody to Embryonic CNS Antigen A2B5 Provides Evidence for the Involvement of Membrane Components at Sites of Alzheimer Degeneration and Detects Sulfatides as Well as Gangliosides, Journal of Neurochemistry, 53, 3, (953-961), (2006).https://doi.org/10.1111/j.1471-4159.1989.tb11798.x
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  8. Disialogangliosides induce neurodegeneration in rat mesencephalic cultures, Biochemical and Biophysical Research Communications, 346, 2, (572-577), (2006).https://doi.org/10.1016/j.bbrc.2006.05.150
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  9. Alz‐50 immunoreactive neuropil differentiates hippocampal complex subfields in Alzheimer's disease, Journal of Comparative Neurology, 305, 3, (489-507), (2004).https://doi.org/10.1002/cne.903050311
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  10. Identification of neuronal plasma membrane microdomains that colocalize β-amyloid and presenilin: implications for β-amyloid precursor protein processing, Neuroscience, 120, 2, (291-300), (2003).https://doi.org/10.1016/S0306-4522(03)00320-8
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