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Articles
February 1, 1993

Pick's disease versus Alzheimer's disease
A comparison of clinical characteristics

February 1993 issue
43 (2) 289

Abstract

The clinical recognition of Pick's disease depends on its differentiation from Alzheimer's disease (AD). To identify distinguishing clinical features, we reviewed the clinical records of 21 patients with pathologically confirmed Pick's disease and matched them by sex, age of onset, and duration of dementia with 42 patients having pathologically confirmed AD. In the absence of temporal or frontal lobar atrophy on CTs, all the Pick patients and none of the AD patients had three of five clinical features: presenile onset (before age 66), an initial personality change, hyperorality, disinhibition, and roaming behavior. In addition, the Pick patients had a tendency toward reiterative and other speech disturbances. These findings suggest that Pick patients are potentially distinguishable from AD patients on the basis of clinical manifestations.

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Published In

Neurology®
Volume 43Number 2February 1993
Pages: 289
PubMed: 8437691

Publication History

Published online: February 1, 1993
Published in print: February 1993

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Affiliations & Disclosures

Mario F. Mendez, MD, PhD
Departments of Neurology (Dr Mendez and A Selwood), Neuropathology (Dr Mastri), and Psychiatry (Dr Frey), St Paul-Ramsey Medical Center and the University of Minnesota, St. Paul, MN. Dr Mastri is now with the Chief Medical Examiner, City of New York, NY.
Allison Selwood, BA
Departments of Neurology (Dr Mendez and A Selwood), Neuropathology (Dr Mastri), and Psychiatry (Dr Frey), St Paul-Ramsey Medical Center and the University of Minnesota, St. Paul, MN. Dr Mastri is now with the Chief Medical Examiner, City of New York, NY.
Angeline R. Mastri, MD
Departments of Neurology (Dr Mendez and A Selwood), Neuropathology (Dr Mastri), and Psychiatry (Dr Frey), St Paul-Ramsey Medical Center and the University of Minnesota, St. Paul, MN. Dr Mastri is now with the Chief Medical Examiner, City of New York, NY.
W. H. Frey, II, PhD
Departments of Neurology (Dr Mendez and A Selwood), Neuropathology (Dr Mastri), and Psychiatry (Dr Frey), St Paul-Ramsey Medical Center and the University of Minnesota, St. Paul, MN. Dr Mastri is now with the Chief Medical Examiner, City of New York, NY.

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